Risk of Subsequent Primary Cancer in Thyroid Cancer Survivors: A Nationwide Population-Based Study
<b>Background:</b> Despite obtaining a good prognosis and long life expectancy, survivors of thyroid cancer can nevertheless develop subsequent primary cancer (SPC). We investigated the risk and types of SPC in patients with thyroid cancer and compared them with subjects without thyroid...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/18/2903 |
| _version_ | 1797580638057922560 |
|---|---|
| author | Min-Su Kim Sang Jun Lee Myeong Hoon Lee Jay Hyug Choi Hyun Wook Han Young Shin Song |
| author_facet | Min-Su Kim Sang Jun Lee Myeong Hoon Lee Jay Hyug Choi Hyun Wook Han Young Shin Song |
| author_sort | Min-Su Kim |
| collection | DOAJ |
| description | <b>Background:</b> Despite obtaining a good prognosis and long life expectancy, survivors of thyroid cancer can nevertheless develop subsequent primary cancer (SPC). We investigated the risk and types of SPC in patients with thyroid cancer and compared them with subjects without thyroid cancer history (controls). <b>Methods:</b> We conducted a nationwide, population-based, retrospective cohort study based on the Korean National Health Insurance Database. A total of 432,654 patients diagnosed with thyroid cancer between 2004 and 2019 were 1:1 matched with controls for age, sex, income, and region of residence. The hazard ratios (HR) and 95% confidence intervals (CI) of SPC were estimated using Cox proportional hazard models. <b>Results:</b> In total, 78,584 (18.2%) patients with thyroid cancer and 49,979 (11.6%) controls were diagnosed with SPCs over a mean follow-up of 6.9 years. Patients with thyroid cancer had a higher risk of SPC at any site (adjusted HR, 1.62; 95% CI, 1.60–1.64) than the controls. The risk of SPCs was particularly high for patients diagnosed with thyroid cancer at a younger age (<40 years) and within 5 years. <b>Conclusions:</b> Medical caregivers should consider the long-term follow-up of patients with thyroid cancer and discuss the risk of SPC, especially if they complain of cancer-related symptoms. |
| first_indexed | 2024-03-10T22:53:42Z |
| format | Article |
| id | doaj.art-e1c18553a1864d2ebfaba7b4b3d71889 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T22:53:42Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e1c18553a1864d2ebfaba7b4b3d718892023-11-19T10:13:14ZengMDPI AGDiagnostics2075-44182023-09-011318290310.3390/diagnostics13182903Risk of Subsequent Primary Cancer in Thyroid Cancer Survivors: A Nationwide Population-Based StudyMin-Su Kim0Sang Jun Lee1Myeong Hoon Lee2Jay Hyug Choi3Hyun Wook Han4Young Shin Song5Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University School of Medicine, CHA University, Seongnam 13496, Republic of KoreaDepartment of Biomedical Informatics, CHA University School of Medicine, CHA University, Seongnam 13496, Republic of KoreaDepartment of Biomedical Informatics, CHA University School of Medicine, CHA University, Seongnam 13496, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University School of Medicine, CHA University, Seongnam 13496, Republic of KoreaDepartment of Biomedical Informatics, CHA University School of Medicine, CHA University, Seongnam 13496, Republic of KoreaDepartment of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Republic of Korea<b>Background:</b> Despite obtaining a good prognosis and long life expectancy, survivors of thyroid cancer can nevertheless develop subsequent primary cancer (SPC). We investigated the risk and types of SPC in patients with thyroid cancer and compared them with subjects without thyroid cancer history (controls). <b>Methods:</b> We conducted a nationwide, population-based, retrospective cohort study based on the Korean National Health Insurance Database. A total of 432,654 patients diagnosed with thyroid cancer between 2004 and 2019 were 1:1 matched with controls for age, sex, income, and region of residence. The hazard ratios (HR) and 95% confidence intervals (CI) of SPC were estimated using Cox proportional hazard models. <b>Results:</b> In total, 78,584 (18.2%) patients with thyroid cancer and 49,979 (11.6%) controls were diagnosed with SPCs over a mean follow-up of 6.9 years. Patients with thyroid cancer had a higher risk of SPC at any site (adjusted HR, 1.62; 95% CI, 1.60–1.64) than the controls. The risk of SPCs was particularly high for patients diagnosed with thyroid cancer at a younger age (<40 years) and within 5 years. <b>Conclusions:</b> Medical caregivers should consider the long-term follow-up of patients with thyroid cancer and discuss the risk of SPC, especially if they complain of cancer-related symptoms.https://www.mdpi.com/2075-4418/13/18/2903thyroid neoplasmssecond primary neoplasmsrisksadult |
| spellingShingle | Min-Su Kim Sang Jun Lee Myeong Hoon Lee Jay Hyug Choi Hyun Wook Han Young Shin Song Risk of Subsequent Primary Cancer in Thyroid Cancer Survivors: A Nationwide Population-Based Study Diagnostics thyroid neoplasms second primary neoplasms risks adult |
| title | Risk of Subsequent Primary Cancer in Thyroid Cancer Survivors: A Nationwide Population-Based Study |
| title_full | Risk of Subsequent Primary Cancer in Thyroid Cancer Survivors: A Nationwide Population-Based Study |
| title_fullStr | Risk of Subsequent Primary Cancer in Thyroid Cancer Survivors: A Nationwide Population-Based Study |
| title_full_unstemmed | Risk of Subsequent Primary Cancer in Thyroid Cancer Survivors: A Nationwide Population-Based Study |
| title_short | Risk of Subsequent Primary Cancer in Thyroid Cancer Survivors: A Nationwide Population-Based Study |
| title_sort | risk of subsequent primary cancer in thyroid cancer survivors a nationwide population based study |
| topic | thyroid neoplasms second primary neoplasms risks adult |
| url | https://www.mdpi.com/2075-4418/13/18/2903 |
| work_keys_str_mv | AT minsukim riskofsubsequentprimarycancerinthyroidcancersurvivorsanationwidepopulationbasedstudy AT sangjunlee riskofsubsequentprimarycancerinthyroidcancersurvivorsanationwidepopulationbasedstudy AT myeonghoonlee riskofsubsequentprimarycancerinthyroidcancersurvivorsanationwidepopulationbasedstudy AT jayhyugchoi riskofsubsequentprimarycancerinthyroidcancersurvivorsanationwidepopulationbasedstudy AT hyunwookhan riskofsubsequentprimarycancerinthyroidcancersurvivorsanationwidepopulationbasedstudy AT youngshinsong riskofsubsequentprimarycancerinthyroidcancersurvivorsanationwidepopulationbasedstudy |