High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids

High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids

Induced Pluripotent Stem Cells (iPSCs) can be differentiated into epithelial organoids that recapitulate the relevant context for CFTR and enable testing of therapies targeting Cystic Fibrosis (CF)-causing mutant proteins. However, to date, CF-iPSC-derived organoids have only been used to study phar...

Full description

Bibliographic Details
Main Authors: Sunny Xia, Zoltán Bozóky, Michelle Di Paola, Onofrio Laselva, Saumel Ahmadi, Jia Xin Jiang, Amy L. Pitstick, Chong Jiang, Daniela Rotin, Christopher N. Mayhew, Nicola L. Jones, Christine E. Bear
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
cystic fibrosis
high throughput
in vitro models
CFTR
ENaC
ion channel activity
Online Access:https://www.mdpi.com/2073-4409/10/12/3419

Internet

https://www.mdpi.com/2073-4409/10/12/3419

Similar Items