Evaluation of Outcome in Patients With Moderate and Severe COVID-19 Via H-Score
Background: Due to uncontrolled lymphocyte reaction, the overproduction of cytokines in COVID-19 patients can cause sepsis-like symptoms, suggesting sepsis, cytokine release syndrome (CRS), and secondary hemophagocytic lymphohistiocytosis (sHLH). Since different therapeutic approaches are used for e...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Shaheed Beheshti University of Medical Sciences
2022-10-01
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| Series: | International Journal of Medical Toxicology and Forensic Medicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/ijmtfm/article/view/37771 |
| _version_ | 1811314884749557760 |
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| author | Shabnam Tehrani Hadiseh Shabanpour Dehbaneh Neda Khabiri Ilad Alavi Darazam Shervin Shokouhi Zahra Sahraei Mana Zaman Minoosh Shabani |
| author_facet | Shabnam Tehrani Hadiseh Shabanpour Dehbaneh Neda Khabiri Ilad Alavi Darazam Shervin Shokouhi Zahra Sahraei Mana Zaman Minoosh Shabani |
| author_sort | Shabnam Tehrani |
| collection | DOAJ |
| description | Background: Due to uncontrolled lymphocyte reaction, the overproduction of cytokines in COVID-19 patients can cause sepsis-like symptoms, suggesting sepsis, cytokine release syndrome (CRS), and secondary hemophagocytic lymphohistiocytosis (sHLH). Since different therapeutic approaches are used for each diagnosis, differentiation is essential. This study aims to use H-score as a possible prognostic tool in COVID-19 patients.
Methods: A sample of 64 moderate and severe COVID-19 patients was enrolled in this study. Clinical and laboratory findings were assessed. H-score was initially calculated and reevaluated among severe cases 72 hours later and among moderate cases showing severe features of COVID-19.
Results: Mortality of 31.3% was reported. Laboratory findings, including triglycerides (TG), ferritin, and aspartate aminotransferase (AST) showed significantly higher initial and follow-up laboratory assessment levels in severe cases than in moderate cases. Moreover, fibrinogen was significantly higher among severe cases than moderate cases at the initial assessment, but no significant difference was reported in the second fibrinogen assessment.
Conclusion: In this study, H-score was useful as a predictive tool for the initial evaluation of severe cases of COVID-19. H-score is much lower in these patients than in non-COVID-19 HLH patients may be due to the different underlying immunologic pathophysiology of COVID-19; thus, each H-score criterion must be evaluated for sensitivity and specificity in COVID-19 patients. The H-score cut-offs, H-score may be useful for diagnosing immune overreaction and determining the need for more exclusive immunomodulatory treatments. |
| first_indexed | 2024-04-13T11:20:22Z |
| format | Article |
| id | doaj.art-e1c31395bfdc43e783b50f08cb4774b6 |
| institution | Directory Open Access Journal |
| issn | 2251-8762 2251-8770 |
| language | English |
| last_indexed | 2024-04-13T11:20:22Z |
| publishDate | 2022-10-01 |
| publisher | Shaheed Beheshti University of Medical Sciences |
| record_format | Article |
| series | International Journal of Medical Toxicology and Forensic Medicine |
| spelling | doaj.art-e1c31395bfdc43e783b50f08cb4774b62022-12-22T02:48:51ZengShaheed Beheshti University of Medical SciencesInternational Journal of Medical Toxicology and Forensic Medicine2251-87622251-87702022-10-01124377713777110.32598/ijmtfm.v12i4.3777137771Evaluation of Outcome in Patients With Moderate and Severe COVID-19 Via H-ScoreShabnam Tehranihttps://orcid.org/0000-0001-7005-5398Hadiseh Shabanpour DehbanehNeda Khabirihttps://orcid.org/0000-0002-7342-4424Ilad Alavi Darazamhttps://orcid.org/0000-0002-4440-335XShervin Shokouhihttps://orcid.org/0000-0002-9611-2466Zahra Sahraeihttps://orcid.org/0000-0002-0178-8624Mana Zamanhttps://orcid.org/0000-0003-3506-8155Minoosh Shabanihttps://orcid.org/0000-0002-4064-8325Background: Due to uncontrolled lymphocyte reaction, the overproduction of cytokines in COVID-19 patients can cause sepsis-like symptoms, suggesting sepsis, cytokine release syndrome (CRS), and secondary hemophagocytic lymphohistiocytosis (sHLH). Since different therapeutic approaches are used for each diagnosis, differentiation is essential. This study aims to use H-score as a possible prognostic tool in COVID-19 patients. Methods: A sample of 64 moderate and severe COVID-19 patients was enrolled in this study. Clinical and laboratory findings were assessed. H-score was initially calculated and reevaluated among severe cases 72 hours later and among moderate cases showing severe features of COVID-19. Results: Mortality of 31.3% was reported. Laboratory findings, including triglycerides (TG), ferritin, and aspartate aminotransferase (AST) showed significantly higher initial and follow-up laboratory assessment levels in severe cases than in moderate cases. Moreover, fibrinogen was significantly higher among severe cases than moderate cases at the initial assessment, but no significant difference was reported in the second fibrinogen assessment. Conclusion: In this study, H-score was useful as a predictive tool for the initial evaluation of severe cases of COVID-19. H-score is much lower in these patients than in non-COVID-19 HLH patients may be due to the different underlying immunologic pathophysiology of COVID-19; thus, each H-score criterion must be evaluated for sensitivity and specificity in COVID-19 patients. The H-score cut-offs, H-score may be useful for diagnosing immune overreaction and determining the need for more exclusive immunomodulatory treatments.https://journals.sbmu.ac.ir/ijmtfm/article/view/37771covid-19h-scorehemophagocytic lymphohistiocytosis |
| spellingShingle | Shabnam Tehrani Hadiseh Shabanpour Dehbaneh Neda Khabiri Ilad Alavi Darazam Shervin Shokouhi Zahra Sahraei Mana Zaman Minoosh Shabani Evaluation of Outcome in Patients With Moderate and Severe COVID-19 Via H-Score International Journal of Medical Toxicology and Forensic Medicine covid-19 h-score hemophagocytic lymphohistiocytosis |
| title | Evaluation of Outcome in Patients With Moderate and Severe COVID-19 Via H-Score |
| title_full | Evaluation of Outcome in Patients With Moderate and Severe COVID-19 Via H-Score |
| title_fullStr | Evaluation of Outcome in Patients With Moderate and Severe COVID-19 Via H-Score |
| title_full_unstemmed | Evaluation of Outcome in Patients With Moderate and Severe COVID-19 Via H-Score |
| title_short | Evaluation of Outcome in Patients With Moderate and Severe COVID-19 Via H-Score |
| title_sort | evaluation of outcome in patients with moderate and severe covid 19 via h score |
| topic | covid-19 h-score hemophagocytic lymphohistiocytosis |
| url | https://journals.sbmu.ac.ir/ijmtfm/article/view/37771 |
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