Effect of Epirubicin Against Glioma Initiating Cells
Background: Glioblastoma is a highly aggressive primary malignant brain tumor. New treatments, especially ones that can eradicate subpopulations with stem-cell-like properties, are currently being explored. In vitro, epirubicin has demonstrated toxicity towards such populations. However, epirubicin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Society of Tokyo Women's Medical University
2020-11-01
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| Series: | Tokyo Women's Medical University Journal |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/twmuj/4/0/4_2020002/_pdf/-char/en |
| _version_ | 1819076772316053504 |
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| author | Atsushi Nakajima Oltea Sampetrean Naoyoshi Koike Masayuki Nitta Takakazu Kawamata Hideyuki Saya Yoshihiro Muragaki |
| author_facet | Atsushi Nakajima Oltea Sampetrean Naoyoshi Koike Masayuki Nitta Takakazu Kawamata Hideyuki Saya Yoshihiro Muragaki |
| author_sort | Atsushi Nakajima |
| collection | DOAJ |
| description | Background: Glioblastoma is a highly aggressive primary malignant brain tumor. New treatments, especially ones that can eradicate subpopulations with stem-cell-like properties, are currently being explored. In vitro, epirubicin has demonstrated toxicity towards such populations. However, epirubicin fails to readily cross the blood-brain barrier. Furthermore, its efficacy against stem-like tumor cells growing within the neural tissue has not been fully addressed. Polymeric micelles are an advanced system developed to enhance drug delivery into tumors.Methods: We have investigated the effect of epirubicin micelles against murine glioma initiating cells (GICs) in vitro and ex vivo.Results: In vitro, epirubicin micelles inhibited the sphere growth of GICs in a dose-dependent manner. Furthermore, they also inhibited the growth of GIC-based tumors in ex vivo cultured brain slices from the tumor-bearing mice. This effect was inversely proportional to the tumor size at the beginning of the treatment.Conclusions: Our results suggest that epirubicin micelles are effective against murine glioma cells with stem cell properties and their use should be initiated at an early stage. |
| first_indexed | 2024-12-21T18:46:37Z |
| format | Article |
| id | doaj.art-e1c31c8097554d7a87ac56216a6eaa74 |
| institution | Directory Open Access Journal |
| issn | 2432-6186 |
| language | English |
| last_indexed | 2024-12-21T18:46:37Z |
| publishDate | 2020-11-01 |
| publisher | Society of Tokyo Women's Medical University |
| record_format | Article |
| series | Tokyo Women's Medical University Journal |
| spelling | doaj.art-e1c31c8097554d7a87ac56216a6eaa742022-12-21T18:53:53ZengSociety of Tokyo Women's Medical UniversityTokyo Women's Medical University Journal2432-61862020-11-0140697610.24488/twmuj.2020002twmujEffect of Epirubicin Against Glioma Initiating CellsAtsushi Nakajima0Oltea Sampetrean1Naoyoshi Koike2Masayuki Nitta3Takakazu Kawamata4Hideyuki Saya5Yoshihiro Muragaki6Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical UniversityDivision of Gene Regulation, Institute for Advanced Medical Research, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineDepartment of Neurosurgery, Tokyo Women's Medical UniversityDepartment of Neurosurgery, Tokyo Women's Medical UniversityDivision of Gene Regulation, Institute for Advanced Medical Research, Keio University School of MedicineInstitute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical UniversityBackground: Glioblastoma is a highly aggressive primary malignant brain tumor. New treatments, especially ones that can eradicate subpopulations with stem-cell-like properties, are currently being explored. In vitro, epirubicin has demonstrated toxicity towards such populations. However, epirubicin fails to readily cross the blood-brain barrier. Furthermore, its efficacy against stem-like tumor cells growing within the neural tissue has not been fully addressed. Polymeric micelles are an advanced system developed to enhance drug delivery into tumors.Methods: We have investigated the effect of epirubicin micelles against murine glioma initiating cells (GICs) in vitro and ex vivo.Results: In vitro, epirubicin micelles inhibited the sphere growth of GICs in a dose-dependent manner. Furthermore, they also inhibited the growth of GIC-based tumors in ex vivo cultured brain slices from the tumor-bearing mice. This effect was inversely proportional to the tumor size at the beginning of the treatment.Conclusions: Our results suggest that epirubicin micelles are effective against murine glioma cells with stem cell properties and their use should be initiated at an early stage.https://www.jstage.jst.go.jp/article/twmuj/4/0/4_2020002/_pdf/-char/enepirubicinepirubicin micelleglioblastomaglioma initiating cellsmicroglia |
| spellingShingle | Atsushi Nakajima Oltea Sampetrean Naoyoshi Koike Masayuki Nitta Takakazu Kawamata Hideyuki Saya Yoshihiro Muragaki Effect of Epirubicin Against Glioma Initiating Cells Tokyo Women's Medical University Journal epirubicin epirubicin micelle glioblastoma glioma initiating cells microglia |
| title | Effect of Epirubicin Against Glioma Initiating Cells |
| title_full | Effect of Epirubicin Against Glioma Initiating Cells |
| title_fullStr | Effect of Epirubicin Against Glioma Initiating Cells |
| title_full_unstemmed | Effect of Epirubicin Against Glioma Initiating Cells |
| title_short | Effect of Epirubicin Against Glioma Initiating Cells |
| title_sort | effect of epirubicin against glioma initiating cells |
| topic | epirubicin epirubicin micelle glioblastoma glioma initiating cells microglia |
| url | https://www.jstage.jst.go.jp/article/twmuj/4/0/4_2020002/_pdf/-char/en |
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