Doxorubicin extravasation from a port-a-cath into pleural space in a young girl: A case report and review of literature
Extravasation of chemotherapeutic agents from a peripheral cannula is a known problem, and to prevent that, oncology units use central vein access with indwelling catheters such as port-a-cath or Hickman catheter. The intrapleural extravasation of chemotherapeutic agents is a rare event. We describe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Journal of Indian Association of Pediatric Surgeons |
| Subjects: | |
| Online Access: | http://www.jiaps.com/article.asp?issn=0971-9261;year=2022;volume=27;issue=5;spage=648;epage=651;aulast=Tom |
| _version_ | 1811342866819055616 |
|---|---|
| author | Alex Tom Jayatheerth Joshi Manoj Kumar Golla Harsha Prasada Lashkari |
| author_facet | Alex Tom Jayatheerth Joshi Manoj Kumar Golla Harsha Prasada Lashkari |
| author_sort | Alex Tom |
| collection | DOAJ |
| description | Extravasation of chemotherapeutic agents from a peripheral cannula is a known problem, and to prevent that, oncology units use central vein access with indwelling catheters such as port-a-cath or Hickman catheter. The intrapleural extravasation of chemotherapeutic agents is a rare event. We describe a 9-year-old girl with newly diagnosed Ewing's sarcoma of the left upper humerus receiving neoadjuvant chemotherapy through a newly inserted port-a-cath device. The patient developed tachypnea and right-sided chest pain on day 2 of chemotherapy. The radiological investigations confirmed the extravasation of doxorubicin into the pleural space. The surgical washout with chest-drain insertion was done, and we continued flushing with normal saline until the drain fluid became clear. She has completed neoadjuvant therapy. This case report shines light into scenarios where extravasation of anthracycline into the pleural cavity or thorax can be managed conservatively and in settings where dexrazoxane is unavailable without causing much delay in restarting the chemotherapy. |
| first_indexed | 2024-04-13T19:19:35Z |
| format | Article |
| id | doaj.art-e1c517b0873a444eb73e2403a412bdda |
| institution | Directory Open Access Journal |
| issn | 0971-9261 1998-3891 |
| language | English |
| last_indexed | 2024-04-13T19:19:35Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Association of Pediatric Surgeons |
| spelling | doaj.art-e1c517b0873a444eb73e2403a412bdda2022-12-22T02:33:35ZengWolters Kluwer Medknow PublicationsJournal of Indian Association of Pediatric Surgeons0971-92611998-38912022-01-0127564865110.4103/jiaps.jiaps_253_21Doxorubicin extravasation from a port-a-cath into pleural space in a young girl: A case report and review of literatureAlex TomJayatheerth JoshiManoj Kumar GollaHarsha Prasada LashkariExtravasation of chemotherapeutic agents from a peripheral cannula is a known problem, and to prevent that, oncology units use central vein access with indwelling catheters such as port-a-cath or Hickman catheter. The intrapleural extravasation of chemotherapeutic agents is a rare event. We describe a 9-year-old girl with newly diagnosed Ewing's sarcoma of the left upper humerus receiving neoadjuvant chemotherapy through a newly inserted port-a-cath device. The patient developed tachypnea and right-sided chest pain on day 2 of chemotherapy. The radiological investigations confirmed the extravasation of doxorubicin into the pleural space. The surgical washout with chest-drain insertion was done, and we continued flushing with normal saline until the drain fluid became clear. She has completed neoadjuvant therapy. This case report shines light into scenarios where extravasation of anthracycline into the pleural cavity or thorax can be managed conservatively and in settings where dexrazoxane is unavailable without causing much delay in restarting the chemotherapy.http://www.jiaps.com/article.asp?issn=0971-9261;year=2022;volume=27;issue=5;spage=648;epage=651;aulast=Tomcancerchemoportchildrendoxorubicinextravasationport-a-cath |
| spellingShingle | Alex Tom Jayatheerth Joshi Manoj Kumar Golla Harsha Prasada Lashkari Doxorubicin extravasation from a port-a-cath into pleural space in a young girl: A case report and review of literature Journal of Indian Association of Pediatric Surgeons cancer chemoport children doxorubicin extravasation port-a-cath |
| title | Doxorubicin extravasation from a port-a-cath into pleural space in a young girl: A case report and review of literature |
| title_full | Doxorubicin extravasation from a port-a-cath into pleural space in a young girl: A case report and review of literature |
| title_fullStr | Doxorubicin extravasation from a port-a-cath into pleural space in a young girl: A case report and review of literature |
| title_full_unstemmed | Doxorubicin extravasation from a port-a-cath into pleural space in a young girl: A case report and review of literature |
| title_short | Doxorubicin extravasation from a port-a-cath into pleural space in a young girl: A case report and review of literature |
| title_sort | doxorubicin extravasation from a port a cath into pleural space in a young girl a case report and review of literature |
| topic | cancer chemoport children doxorubicin extravasation port-a-cath |
| url | http://www.jiaps.com/article.asp?issn=0971-9261;year=2022;volume=27;issue=5;spage=648;epage=651;aulast=Tom |
| work_keys_str_mv | AT alextom doxorubicinextravasationfromaportacathintopleuralspaceinayounggirlacasereportandreviewofliterature AT jayatheerthjoshi doxorubicinextravasationfromaportacathintopleuralspaceinayounggirlacasereportandreviewofliterature AT manojkumargolla doxorubicinextravasationfromaportacathintopleuralspaceinayounggirlacasereportandreviewofliterature AT harshaprasadalashkari doxorubicinextravasationfromaportacathintopleuralspaceinayounggirlacasereportandreviewofliterature |