A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation
Abstract Invasive nontyphoidal Salmonella (iNTS) causes extraintestinal infections with ~15% case fatality in many countries. However, the mechanism by which iNTS emerged in China remains unaddressed. We conducted clinical investigations of iNTS infection with recurrent treatment failure, caused by...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2022-11-01
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| Series: | EMBO Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.15252/emmm.202216366 |
| _version_ | 1797230018891350016 |
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| author | Yan Li Lin Teng Xuebin Xu Xiaomeng Li Xianqi Peng Xiao Zhou Jiaxin Du Yanting Tang Zhijie Jiang Zining Wang Chenghao Jia Anja Müller Corinna Kehrenberg Haoqiu Wang Beibei Wu François‐Xavier Weill Min Yue |
| author_facet | Yan Li Lin Teng Xuebin Xu Xiaomeng Li Xianqi Peng Xiao Zhou Jiaxin Du Yanting Tang Zhijie Jiang Zining Wang Chenghao Jia Anja Müller Corinna Kehrenberg Haoqiu Wang Beibei Wu François‐Xavier Weill Min Yue |
| author_sort | Yan Li |
| collection | DOAJ |
| description | Abstract Invasive nontyphoidal Salmonella (iNTS) causes extraintestinal infections with ~15% case fatality in many countries. However, the mechanism by which iNTS emerged in China remains unaddressed. We conducted clinical investigations of iNTS infection with recurrent treatment failure, caused by underreported Salmonella enterica serovar Livingstone (SL). Genomic epidemiology demonstrated five clades in the SL population and suggested that the international animal feed trade was a likely vehicle for their introduction into China, as evidenced by multiple independent transmission incidents. Importantly, isolates from Clade‐5‐I‐a/b, predominant in China, showed an invasive nature in mice, chicken and zebrafish infection models. The antimicrobial susceptibility testing revealed most isolates (> 96%) in China are multidrug‐resistant (MDR). Overall, we offer exploiting genomics in uncovering international transmission led by the animal feed trade and highlight an emerging hypervirulent clade with increased resistance to frontline antibiotics. |
| first_indexed | 2024-04-24T15:21:49Z |
| format | Article |
| id | doaj.art-e1c57f62f37048ffb52a63f3c1fcfd6a |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-04-24T15:21:49Z |
| publishDate | 2022-11-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-e1c57f62f37048ffb52a63f3c1fcfd6a2024-04-02T07:59:53ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842022-11-011411n/an/a10.15252/emmm.202216366A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptationYan Li0Lin Teng1Xuebin Xu2Xiaomeng Li3Xianqi Peng4Xiao Zhou5Jiaxin Du6Yanting Tang7Zhijie Jiang8Zining Wang9Chenghao Jia10Anja Müller11Corinna Kehrenberg12Haoqiu Wang13Beibei Wu14François‐Xavier Weill15Min Yue16Hainan Institute of Zhejiang University Sanya ChinaInstitute of Preventive Veterinary Science & Department of Veterinary Medicine Zhejiang University College of Animal Sciences Hangzhou ChinaShanghai Municipal Center for Disease Control and Prevention Shanghai ChinaInstitute of Preventive Veterinary Science & Department of Veterinary Medicine Zhejiang University College of Animal Sciences Hangzhou ChinaInstitute of Preventive Veterinary Science & Department of Veterinary Medicine Zhejiang University College of Animal Sciences Hangzhou ChinaInstitute of Preventive Veterinary Science & Department of Veterinary Medicine Zhejiang University College of Animal Sciences Hangzhou ChinaInstitute of Preventive Veterinary Science & Department of Veterinary Medicine Zhejiang University College of Animal Sciences Hangzhou ChinaInstitute of Preventive Veterinary Science & Department of Veterinary Medicine Zhejiang University College of Animal Sciences Hangzhou ChinaInstitute of Preventive Veterinary Science & Department of Veterinary Medicine Zhejiang University College of Animal Sciences Hangzhou ChinaHainan Institute of Zhejiang University Sanya ChinaHainan Institute of Zhejiang University Sanya ChinaInstitute for Veterinary Food Science, Faculty of Veterinary Medicine Justus‐Liebig University Giessen Giessen GermanyInstitute for Veterinary Food Science, Faculty of Veterinary Medicine Justus‐Liebig University Giessen Giessen GermanyHangzhou Center for Disease Control and Prevention Hangzhou ChinaZhejiang Province Center for Disease Control and Prevention Hangzhou ChinaDepartment of Global Health Institut Pasteur Paris FranceHainan Institute of Zhejiang University Sanya ChinaAbstract Invasive nontyphoidal Salmonella (iNTS) causes extraintestinal infections with ~15% case fatality in many countries. However, the mechanism by which iNTS emerged in China remains unaddressed. We conducted clinical investigations of iNTS infection with recurrent treatment failure, caused by underreported Salmonella enterica serovar Livingstone (SL). Genomic epidemiology demonstrated five clades in the SL population and suggested that the international animal feed trade was a likely vehicle for their introduction into China, as evidenced by multiple independent transmission incidents. Importantly, isolates from Clade‐5‐I‐a/b, predominant in China, showed an invasive nature in mice, chicken and zebrafish infection models. The antimicrobial susceptibility testing revealed most isolates (> 96%) in China are multidrug‐resistant (MDR). Overall, we offer exploiting genomics in uncovering international transmission led by the animal feed trade and highlight an emerging hypervirulent clade with increased resistance to frontline antibiotics.https://doi.org/10.15252/emmm.202216366antimicrobial resistanceevolutionhost adaptationinvasive nontyphoidal SalmonellaLivingstone |
| spellingShingle | Yan Li Lin Teng Xuebin Xu Xiaomeng Li Xianqi Peng Xiao Zhou Jiaxin Du Yanting Tang Zhijie Jiang Zining Wang Chenghao Jia Anja Müller Corinna Kehrenberg Haoqiu Wang Beibei Wu François‐Xavier Weill Min Yue A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation EMBO Molecular Medicine antimicrobial resistance evolution host adaptation invasive nontyphoidal Salmonella Livingstone |
| title | A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation |
| title_full | A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation |
| title_fullStr | A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation |
| title_full_unstemmed | A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation |
| title_short | A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation |
| title_sort | nontyphoidal salmonella serovar domestication accompanying enhanced niche adaptation |
| topic | antimicrobial resistance evolution host adaptation invasive nontyphoidal Salmonella Livingstone |
| url | https://doi.org/10.15252/emmm.202216366 |
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