An indirect comparison of HbA1c treatment effect with albiglutide and exenatide 2.0 mg QW using the Bucher method
Alan A Martin,1 Daniel Parks2 1Department of Value Evidence Analytics, GlaxoSmithKline, Uxbridge, Middlesex, UK; 2Department of Value Evidence Analytics, GlaxoSmithKline, Collegeville, PA, USA Abstract: No head-to-head comparisons exist between once-weekly (QW) glucagon-like peptide-1 receptor agoni...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/an-indirect-comparison-of-hba1c-treatment-effect-with-albiglutide-and--peer-reviewed-article-DMSO |
| _version_ | 1797713248887242752 |
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| author | Martin AA Parks D |
| author_facet | Martin AA Parks D |
| author_sort | Martin AA |
| collection | DOAJ |
| description | Alan A Martin,1 Daniel Parks2 1Department of Value Evidence Analytics, GlaxoSmithKline, Uxbridge, Middlesex, UK; 2Department of Value Evidence Analytics, GlaxoSmithKline, Collegeville, PA, USA Abstract: No head-to-head comparisons exist between once-weekly (QW) glucagon-like peptide-1 receptor agonists; accordingly, this indirect comparison was conducted to evaluate the comparative efficacy of QW albiglutide vs QW exenatide. Following a systematic literature search, it was determined that HARMONY 7 and DURATION 6, Phase III trials for albiglutide and exenatide, respectively, were similar in study design and baseline characteristics and included a common comparator arm, making them suitable for an indirect comparison using the Bucher method. The primary endpoint of change from baseline in glycated hemoglobin (HbA1c) with albiglutide 50 mg QW and exenatide 2.0 mg QW was compared and tested for noninferiority. The indirect comparison showed a treatment difference of 0.0% (95% confidence interval: -0.189% to 0.189%) in mean change in HbA1c from baseline, and albiglutide 50 mg was noninferior to exenatide 2.0 mg QW at the noninferiority margin of 0.3%. In the absence of a head-to-head trial, these results can be used in pharmacoeconomic analysis and to inform health technology assessment and clinical decision making. Keywords: albiglutide, exenatide 2.0 mg QW GLP-1 RA, Bucher method |
| first_indexed | 2024-03-12T07:33:37Z |
| format | Article |
| id | doaj.art-e1c6761f3e404fedb576f634058e8b92 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-12T07:33:37Z |
| publishDate | 2016-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-e1c6761f3e404fedb576f634058e8b922023-09-02T21:39:23ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072016-05-012016Issue 116316827011An indirect comparison of HbA1c treatment effect with albiglutide and exenatide 2.0 mg QW using the Bucher methodMartin AAParks DAlan A Martin,1 Daniel Parks2 1Department of Value Evidence Analytics, GlaxoSmithKline, Uxbridge, Middlesex, UK; 2Department of Value Evidence Analytics, GlaxoSmithKline, Collegeville, PA, USA Abstract: No head-to-head comparisons exist between once-weekly (QW) glucagon-like peptide-1 receptor agonists; accordingly, this indirect comparison was conducted to evaluate the comparative efficacy of QW albiglutide vs QW exenatide. Following a systematic literature search, it was determined that HARMONY 7 and DURATION 6, Phase III trials for albiglutide and exenatide, respectively, were similar in study design and baseline characteristics and included a common comparator arm, making them suitable for an indirect comparison using the Bucher method. The primary endpoint of change from baseline in glycated hemoglobin (HbA1c) with albiglutide 50 mg QW and exenatide 2.0 mg QW was compared and tested for noninferiority. The indirect comparison showed a treatment difference of 0.0% (95% confidence interval: -0.189% to 0.189%) in mean change in HbA1c from baseline, and albiglutide 50 mg was noninferior to exenatide 2.0 mg QW at the noninferiority margin of 0.3%. In the absence of a head-to-head trial, these results can be used in pharmacoeconomic analysis and to inform health technology assessment and clinical decision making. Keywords: albiglutide, exenatide 2.0 mg QW GLP-1 RA, Bucher methodhttps://www.dovepress.com/an-indirect-comparison-of-hba1c-treatment-effect-with-albiglutide-and--peer-reviewed-article-DMSOAlbiglutideexenatide QWGLP-1 RABucher method |
| spellingShingle | Martin AA Parks D An indirect comparison of HbA1c treatment effect with albiglutide and exenatide 2.0 mg QW using the Bucher method Diabetes, Metabolic Syndrome and Obesity Albiglutide exenatide QW GLP-1 RA Bucher method |
| title | An indirect comparison of HbA1c treatment effect with albiglutide and exenatide 2.0 mg QW using the Bucher method |
| title_full | An indirect comparison of HbA1c treatment effect with albiglutide and exenatide 2.0 mg QW using the Bucher method |
| title_fullStr | An indirect comparison of HbA1c treatment effect with albiglutide and exenatide 2.0 mg QW using the Bucher method |
| title_full_unstemmed | An indirect comparison of HbA1c treatment effect with albiglutide and exenatide 2.0 mg QW using the Bucher method |
| title_short | An indirect comparison of HbA1c treatment effect with albiglutide and exenatide 2.0 mg QW using the Bucher method |
| title_sort | indirect comparison of hba1c treatment effect with albiglutide and exenatide 2 0 mg qw using the bucher method |
| topic | Albiglutide exenatide QW GLP-1 RA Bucher method |
| url | https://www.dovepress.com/an-indirect-comparison-of-hba1c-treatment-effect-with-albiglutide-and--peer-reviewed-article-DMSO |
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