Phospholipids as dynamic participants in biological processes
Phospholipids are described as active biological molecules. Three distinctly different roles are examined. The first centers on protein-lipid interactions and the lipid requirement expressed by certain enzymes. This category is illustrated by two soluble proteins of the blood coagulation scheme, Fac...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1984-12-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752034428X |
| _version_ | 1819299383717396480 |
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| author | D J Hanahan D R Nelson |
| author_facet | D J Hanahan D R Nelson |
| author_sort | D J Hanahan |
| collection | DOAJ |
| description | Phospholipids are described as active biological molecules. Three distinctly different roles are examined. The first centers on protein-lipid interactions and the lipid requirement expressed by certain enzymes. This category is illustrated by two soluble proteins of the blood coagulation scheme, Factor IXa and Factor Xa, and by an integral membrane protein, the (Ca2+ + Mg2+)-ATPase of human erythrocytes. The next two examples depict phospholipids as active participants in membrane-mediated events. In the first of these, termed the phosphoinositide effect, a phospholipid becomes a substrate during membrane signaling, and its products presumably act as second messengers. In the second example, a phospholipid is a signal that, among other reactions, induces the phosphoinositide effect. Here, the phospholipid (platelet activating factor) serves as a lipid chemical mediator. These examples show that phospholipids behave not only as structural molecules but also as dynamic, functionally important components of cells. |
| first_indexed | 2024-12-24T05:44:56Z |
| format | Article |
| id | doaj.art-e1c7fe09bf864b27b35e47ebee5749d6 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-24T05:44:56Z |
| publishDate | 1984-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-e1c7fe09bf864b27b35e47ebee5749d62022-12-21T17:12:39ZengElsevierJournal of Lipid Research0022-22751984-12-01251315281535Phospholipids as dynamic participants in biological processesD J HanahanD R NelsonPhospholipids are described as active biological molecules. Three distinctly different roles are examined. The first centers on protein-lipid interactions and the lipid requirement expressed by certain enzymes. This category is illustrated by two soluble proteins of the blood coagulation scheme, Factor IXa and Factor Xa, and by an integral membrane protein, the (Ca2+ + Mg2+)-ATPase of human erythrocytes. The next two examples depict phospholipids as active participants in membrane-mediated events. In the first of these, termed the phosphoinositide effect, a phospholipid becomes a substrate during membrane signaling, and its products presumably act as second messengers. In the second example, a phospholipid is a signal that, among other reactions, induces the phosphoinositide effect. Here, the phospholipid (platelet activating factor) serves as a lipid chemical mediator. These examples show that phospholipids behave not only as structural molecules but also as dynamic, functionally important components of cells.http://www.sciencedirect.com/science/article/pii/S002222752034428X |
| spellingShingle | D J Hanahan D R Nelson Phospholipids as dynamic participants in biological processes Journal of Lipid Research |
| title | Phospholipids as dynamic participants in biological processes |
| title_full | Phospholipids as dynamic participants in biological processes |
| title_fullStr | Phospholipids as dynamic participants in biological processes |
| title_full_unstemmed | Phospholipids as dynamic participants in biological processes |
| title_short | Phospholipids as dynamic participants in biological processes |
| title_sort | phospholipids as dynamic participants in biological processes |
| url | http://www.sciencedirect.com/science/article/pii/S002222752034428X |
| work_keys_str_mv | AT djhanahan phospholipidsasdynamicparticipantsinbiologicalprocesses AT drnelson phospholipidsasdynamicparticipantsinbiologicalprocesses |