The influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studies
Abstract It is reported that glutathione S-transferase mu (GSTM1) polymorphism is associated with non-viral hepatic cirrhosis (HC). However, some studies showed different views. Therefore, in this paper, a meta-analysis was conducted to get a more comprehensive understanding of GSTM1 polymorphisms i...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | European Journal of Medical Research |
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| Online Access: | http://link.springer.com/article/10.1186/s40001-018-0331-z |
| _version_ | 1818997061810388992 |
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| author | Ye Gu Jing Zhao Li Ao Jianning Ma Kena Bao Min Liu Weiping Huang |
| author_facet | Ye Gu Jing Zhao Li Ao Jianning Ma Kena Bao Min Liu Weiping Huang |
| author_sort | Ye Gu |
| collection | DOAJ |
| description | Abstract It is reported that glutathione S-transferase mu (GSTM1) polymorphism is associated with non-viral hepatic cirrhosis (HC). However, some studies showed different views. Therefore, in this paper, a meta-analysis was conducted to get a more comprehensive understanding of GSTM1 polymorphisms in non-viral HC susceptibility. The results showed that GSTM1 null was associated with the increased risk of non-viral HC (OR = 1.337, 95% CI 1.112–1.804, p = 0.005). Subgroup analysis of cirrhosis type revealed that GSTM1 null was a prominent risk factor for alcoholic HC (OR = 1.416, 95% CI 1.112–1.804, p = 0.005). Meanwhile, subgroup analysis of population indicated that the significant differences only existed in Asian population (OR = 1.719, 95% CI 1.212–2.438, p = 0.002). In hospital-based studies, patients with GSTM1 null were more likely in risk of HC (OR = 1.426, 95% CI 1.092–1.863, p = 0.009). Subgroup analysis using genotyping method showed a significant association between GSTM1 null genotype and HC occurrence in the studies employing the multiple PCR genotyping method (OR = 1.559, 95% CI 1.171–2.076, p = 0.002). Based on the results of this analysis, it was concluded that GSTM1 null genotype could increase the susceptibility of non-viral hepatic cirrhosis. In addition, alcohol intake, Asian ethnicity, sample source from hospital and multiple PCR genotyping method may also influence the susceptibility of hepatic cirrhosis. |
| first_indexed | 2024-12-20T21:39:39Z |
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| id | doaj.art-e1c8b57ca7f840fb96f5dcd2080ae343 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-20T21:39:39Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-e1c8b57ca7f840fb96f5dcd2080ae3432022-12-21T19:25:51ZengBMCEuropean Journal of Medical Research2047-783X2018-06-012311910.1186/s40001-018-0331-zThe influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studiesYe Gu0Jing Zhao1Li Ao2Jianning Ma3Kena Bao4Min Liu5Weiping Huang6Department of Nursing, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health SciencesDepartment of Nursing, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health SciencesDepartment of Nursing, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health SciencesDepartment of Nursing, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health SciencesDepartment of Nursing, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health SciencesDepartment of Scientific Research, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health SciencesDepartment of Nursing, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health SciencesAbstract It is reported that glutathione S-transferase mu (GSTM1) polymorphism is associated with non-viral hepatic cirrhosis (HC). However, some studies showed different views. Therefore, in this paper, a meta-analysis was conducted to get a more comprehensive understanding of GSTM1 polymorphisms in non-viral HC susceptibility. The results showed that GSTM1 null was associated with the increased risk of non-viral HC (OR = 1.337, 95% CI 1.112–1.804, p = 0.005). Subgroup analysis of cirrhosis type revealed that GSTM1 null was a prominent risk factor for alcoholic HC (OR = 1.416, 95% CI 1.112–1.804, p = 0.005). Meanwhile, subgroup analysis of population indicated that the significant differences only existed in Asian population (OR = 1.719, 95% CI 1.212–2.438, p = 0.002). In hospital-based studies, patients with GSTM1 null were more likely in risk of HC (OR = 1.426, 95% CI 1.092–1.863, p = 0.009). Subgroup analysis using genotyping method showed a significant association between GSTM1 null genotype and HC occurrence in the studies employing the multiple PCR genotyping method (OR = 1.559, 95% CI 1.171–2.076, p = 0.002). Based on the results of this analysis, it was concluded that GSTM1 null genotype could increase the susceptibility of non-viral hepatic cirrhosis. In addition, alcohol intake, Asian ethnicity, sample source from hospital and multiple PCR genotyping method may also influence the susceptibility of hepatic cirrhosis.http://link.springer.com/article/10.1186/s40001-018-0331-zHepatic cirrhosis (HC)GSTM1Polymorphism |
| spellingShingle | Ye Gu Jing Zhao Li Ao Jianning Ma Kena Bao Min Liu Weiping Huang The influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studies European Journal of Medical Research Hepatic cirrhosis (HC) GSTM1 Polymorphism |
| title | The influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studies |
| title_full | The influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studies |
| title_fullStr | The influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studies |
| title_full_unstemmed | The influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studies |
| title_short | The influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studies |
| title_sort | influence of polymorphic gstm1 gene on the increased susceptibility of non viral hepatic cirrhosis evidence from observational studies |
| topic | Hepatic cirrhosis (HC) GSTM1 Polymorphism |
| url | http://link.springer.com/article/10.1186/s40001-018-0331-z |
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