The NF-κB specific inhibitor DHMEQ prevents thrombus formation in a mouse model of antiphospholipid syndrome

The NF-κB specific inhibitor DHMEQ prevents thrombus formation in a mouse model of antiphospholipid syndrome

Background: β2-glycoprotein I (β2GPI)-dependent antiphospholipid antibodies (aPLs) are considered to play a pivotal pathogenic role in antiphospholipid syndrome (APS) by inducing the expression of tissue factor, inflammatory cytokines, and chemokines, most of which are dependent upon the NF-κB pathw...

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Bibliographic Details
Main Authors: Misato Nishimura, Tokiko Nii, Gulzhan Trimova, Shuhei Miura, Kazuo Umezawa, Akira Ushiyama, Tetsuo Kubota
Format: Article
Language:English
Published: Society of Diabetic Nephropathy Prevention 2013-04-01
Series:Journal of Nephropathology
Subjects:
antiphospholipid syndrome
nf-kappa b
tissue factor
thrombosis
Online Access:https://nephropathol.com/PDF/jnp-2-114.pdf

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