Vaccination targeting human HER3 alters the phenotype of infiltrating T cells and responses to immune checkpoint inhibition

Vaccination targeting human HER3 alters the phenotype of infiltrating T cells and responses to immune checkpoint inhibition

Expression of human epidermal growth factor family member 3 (HER3), a critical heterodimerization partner with EGFR and HER2, promotes more aggressive biology in breast and other epithelial malignancies. As such, inhibiting HER3 could have broad applicability to the treatment of EGFR- and HER2-drive...

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Bibliographic Details
Main Authors: Takuya Osada, Michael A. Morse, Amy Hobeika, Marcio A. Diniz, William R. Gwin, Zachary Hartman, Junping Wei, Hongtao Guo, Xiao-Yi Yang, Cong-Xiao Liu, Kensuke Kaneko, Gloria Broadwater, H. Kim Lyerly
Format: Article
Language:English
Published: Taylor & Francis Group 2017-06-01
Series:OncoImmunology
Subjects:
adenovirus
anti-pd-1
anti-pd-l1
her2
her3
immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1315495

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