GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy
Gastrodia elata exhibits extensive pharmacological activity; its extract gastrodin (GAS) has been used clinically to treat cardiovascular diseases. In the present study, we examined the effect of GAS in a mice model of pathological cardiac hypertrophy, which was induced using transverse aortic const...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223001129 |
| _version_ | 1797857784436359168 |
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| author | Miao Zhang Yanzhen Tan Yujie Song Min zhu Bing Zhang Cheng Chen Yingying Liu Lei Shi Jun Cui Wenju Shan Zipei Jia Lele Feng Guojie Cao Wei Yi Yang Sun |
| author_facet | Miao Zhang Yanzhen Tan Yujie Song Min zhu Bing Zhang Cheng Chen Yingying Liu Lei Shi Jun Cui Wenju Shan Zipei Jia Lele Feng Guojie Cao Wei Yi Yang Sun |
| author_sort | Miao Zhang |
| collection | DOAJ |
| description | Gastrodia elata exhibits extensive pharmacological activity; its extract gastrodin (GAS) has been used clinically to treat cardiovascular diseases. In the present study, we examined the effect of GAS in a mice model of pathological cardiac hypertrophy, which was induced using transverse aortic constriction (TAC). Male C57BL/6 J mice underwent either TAC or sham surgery. GAS was administered post-surgically for 6 weeks and significantly improved the deterioration of cardiac contractile function caused by pressure overload, cardiac hypertrophy, and fibrosis in mice. Treatment with GAS for 6 weeks upregulated myosin heavy chain α and down-regulated myosin heavy chain β and atrial natriuretic peptide, while insulin increased the effects of GAS against cardiac hypertrophy. In vitro studies showed that GAS could also protect phenylephrine-induced cardiomyocyte hypertrophy, and these effects were attenuated by BAY-876, and increased by insulin. Taken together, our results suggest that the anti-hypertrophic effect of gastrodin depends on its entry into cardiomyocytes through GLUT4. |
| first_indexed | 2024-04-09T21:02:24Z |
| format | Article |
| id | doaj.art-e1cad9218ad4468eb65f97913ca27e7a |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T21:02:24Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-e1cad9218ad4468eb65f97913ca27e7a2023-03-29T09:21:12ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-05-01161114324GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophyMiao Zhang0Yanzhen Tan1Yujie Song2Min zhu3Bing Zhang4Cheng Chen5Yingying Liu6Lei Shi7Jun Cui8Wenju Shan9Zipei Jia10Lele Feng11Guojie Cao12Wei Yi13Yang Sun14Department of General Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of General Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of General Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of General Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of General Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of General Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China; Corresponding authors.Department of General Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China; Corresponding authors.Gastrodia elata exhibits extensive pharmacological activity; its extract gastrodin (GAS) has been used clinically to treat cardiovascular diseases. In the present study, we examined the effect of GAS in a mice model of pathological cardiac hypertrophy, which was induced using transverse aortic constriction (TAC). Male C57BL/6 J mice underwent either TAC or sham surgery. GAS was administered post-surgically for 6 weeks and significantly improved the deterioration of cardiac contractile function caused by pressure overload, cardiac hypertrophy, and fibrosis in mice. Treatment with GAS for 6 weeks upregulated myosin heavy chain α and down-regulated myosin heavy chain β and atrial natriuretic peptide, while insulin increased the effects of GAS against cardiac hypertrophy. In vitro studies showed that GAS could also protect phenylephrine-induced cardiomyocyte hypertrophy, and these effects were attenuated by BAY-876, and increased by insulin. Taken together, our results suggest that the anti-hypertrophic effect of gastrodin depends on its entry into cardiomyocytes through GLUT4.http://www.sciencedirect.com/science/article/pii/S0753332223001129GastrodinCardiac hypertrophyGLUT4 |
| spellingShingle | Miao Zhang Yanzhen Tan Yujie Song Min zhu Bing Zhang Cheng Chen Yingying Liu Lei Shi Jun Cui Wenju Shan Zipei Jia Lele Feng Guojie Cao Wei Yi Yang Sun GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy Biomedicine & Pharmacotherapy Gastrodin Cardiac hypertrophy GLUT4 |
| title | GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy |
| title_full | GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy |
| title_fullStr | GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy |
| title_full_unstemmed | GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy |
| title_short | GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy |
| title_sort | glut4 mediates the protective function of gastrodin against pressure overload induced cardiac hypertrophy |
| topic | Gastrodin Cardiac hypertrophy GLUT4 |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223001129 |
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