Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers
Background: the increasing number of COVID-19 vaccines available to the public may trigger hesitancy or selectivity towards vaccination. This study aimed to evaluate the post-vaccination side effects of the different vaccines approved in Germany; Methods: a cross-sectional survey-based study was car...
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MDPI AG
2021-08-01
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| Online Access: | https://www.mdpi.com/2079-7737/10/8/752 |
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| author | Miloslav Klugar Abanoub Riad Mohamed Mekhemar Jonas Conrad Mayte Buchbender Hans-Peter Howaldt Sameh Attia |
| author_facet | Miloslav Klugar Abanoub Riad Mohamed Mekhemar Jonas Conrad Mayte Buchbender Hans-Peter Howaldt Sameh Attia |
| author_sort | Miloslav Klugar |
| collection | DOAJ |
| description | Background: the increasing number of COVID-19 vaccines available to the public may trigger hesitancy or selectivity towards vaccination. This study aimed to evaluate the post-vaccination side effects of the different vaccines approved in Germany; Methods: a cross-sectional survey-based study was carried out using an online questionnaire validated and tested for a priori reliability. The questionnaire inquired about demographic data, medical and COVID-19-related anamneses, and local, systemic, oral, and skin-related side effects following COVID-19 vaccination; Results: out of the 599 participating healthcare workers, 72.3% were females, and 79.1% received mRNA-based vaccines, while 20.9% received a viral vector-based vaccine. 88.1% of the participants reported at least one side effect. Injection site pain (75.6%) was the most common local side effect, and headache/fatigue (53.6%), muscle pain (33.2%), malaise (25%), chills (23%), and joint pain (21.2%) were the most common systemic side effects. The vast majority (84.9%) of side effects resolved within 1–3 days post-vaccination; Conclusions: the mRNA-based vaccines were associated with a higher prevalence of local side effects (78.3% vs. 70.4%; <i>Sig.</i> = 0.064), while the viral vector-based vaccine was associated with a higher prevalence of systemic side effects (87.2% vs. 61%; <i>Sig.</i> < 0.001). Females and the younger age group were associated with an increased risk of side effects either after mRNA-based or viral vector-based vaccines. The gender- and age-based differences warrant further rigorous investigation and standardized methodology. |
| first_indexed | 2024-03-10T09:00:51Z |
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| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T09:00:51Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-e1cbcc87c2d54b2cbb8491f985a44d3b2023-11-22T06:50:01ZengMDPI AGBiology2079-77372021-08-0110875210.3390/biology10080752Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare WorkersMiloslav Klugar0Abanoub Riad1Mohamed Mekhemar2Jonas Conrad3Mayte Buchbender4Hans-Peter Howaldt5Sameh Attia6Czech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech RepublicCzech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech RepublicClinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Kiel University, Arnold Heller Str. 3, Haus B, 24105 Kiel, GermanyClinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Kiel University, Arnold Heller Str. 3, Haus B, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91054 Erlangen, GermanyDepartment of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, GermanyBackground: the increasing number of COVID-19 vaccines available to the public may trigger hesitancy or selectivity towards vaccination. This study aimed to evaluate the post-vaccination side effects of the different vaccines approved in Germany; Methods: a cross-sectional survey-based study was carried out using an online questionnaire validated and tested for a priori reliability. The questionnaire inquired about demographic data, medical and COVID-19-related anamneses, and local, systemic, oral, and skin-related side effects following COVID-19 vaccination; Results: out of the 599 participating healthcare workers, 72.3% were females, and 79.1% received mRNA-based vaccines, while 20.9% received a viral vector-based vaccine. 88.1% of the participants reported at least one side effect. Injection site pain (75.6%) was the most common local side effect, and headache/fatigue (53.6%), muscle pain (33.2%), malaise (25%), chills (23%), and joint pain (21.2%) were the most common systemic side effects. The vast majority (84.9%) of side effects resolved within 1–3 days post-vaccination; Conclusions: the mRNA-based vaccines were associated with a higher prevalence of local side effects (78.3% vs. 70.4%; <i>Sig.</i> = 0.064), while the viral vector-based vaccine was associated with a higher prevalence of systemic side effects (87.2% vs. 61%; <i>Sig.</i> < 0.001). Females and the younger age group were associated with an increased risk of side effects either after mRNA-based or viral vector-based vaccines. The gender- and age-based differences warrant further rigorous investigation and standardized methodology.https://www.mdpi.com/2079-7737/10/8/752adverse effectsBTN162 vaccineChAdOx1 COVID-19 vaccinecross-sectional studiesCOVID-19 vaccinesdrug-related side effects and adverse reactions |
| spellingShingle | Miloslav Klugar Abanoub Riad Mohamed Mekhemar Jonas Conrad Mayte Buchbender Hans-Peter Howaldt Sameh Attia Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers Biology adverse effects BTN162 vaccine ChAdOx1 COVID-19 vaccine cross-sectional studies COVID-19 vaccines drug-related side effects and adverse reactions |
| title | Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers |
| title_full | Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers |
| title_fullStr | Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers |
| title_full_unstemmed | Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers |
| title_short | Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers |
| title_sort | side effects of mrna based and viral vector based covid 19 vaccines among german healthcare workers |
| topic | adverse effects BTN162 vaccine ChAdOx1 COVID-19 vaccine cross-sectional studies COVID-19 vaccines drug-related side effects and adverse reactions |
| url | https://www.mdpi.com/2079-7737/10/8/752 |
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