Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer
We aimed to investigate the impact of muscle atrophy and the neutrophil-to-lymphocyte ratio (NLR), a sub-clinical biomarker of inflammation and nutrition, on the prognosis of patients with unresectable advanced gastric cancer. We retrospectively enrolled 109 patients with stage IV gastric cancer (me...
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MDPI AG
2020-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1884 |
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| author | Kota Shigeto Takumi Kawaguchi Shunji Koya Keisuke Hirota Toshimitsu Tanaka Sachiko Nagasu Masaru Fukahori Tomoyuki Ushijima Hiroo Matsuse Keisuke Miwa Koji Nagafuji Takuji Torimura |
| author_facet | Kota Shigeto Takumi Kawaguchi Shunji Koya Keisuke Hirota Toshimitsu Tanaka Sachiko Nagasu Masaru Fukahori Tomoyuki Ushijima Hiroo Matsuse Keisuke Miwa Koji Nagafuji Takuji Torimura |
| author_sort | Kota Shigeto |
| collection | DOAJ |
| description | We aimed to investigate the impact of muscle atrophy and the neutrophil-to-lymphocyte ratio (NLR), a sub-clinical biomarker of inflammation and nutrition, on the prognosis of patients with unresectable advanced gastric cancer. We retrospectively enrolled 109 patients with stage IV gastric cancer (median age 69 years; female/male 22%/78%; median observational period 261 days). Independent factors and profiles for overall survival (OS) were determined by Cox regression analysis and decision-tree analysis, respectively. OS was calculated using the Kaplan–Meier method. The prevalence of muscle atrophy was 82.6% and the median NLR was 3.15. In Cox regression analysis, none of factors were identified as an independent factor for survival. The decision-tree analysis revealed that the most favorable prognostic profile was non-muscle atrophy (OS rate 36.8%). The most unfavorable prognostic profile was the combination of muscle atrophy and high NLR (OS rate 19.6%). The OS rate was significantly lower in patients with muscle atrophy and high NLR than in patients with non-muscle atrophy (1-year survival rate 28.5% vs. 54.7%; log-rank test <i>p</i> = 0.0014). In conclusion, “muscle atrophy and high NLR” was a prognostic profile for patients with stage IV gastric cancer. Thus, the assessment of muscle mass, subclinical inflammation, and malnutrition may be important for the management of patients with stage IV gastric cancer. |
| first_indexed | 2024-03-10T18:55:48Z |
| format | Article |
| id | doaj.art-e1ce34a3b38a4dcb80ffc4069b9312ac |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:55:48Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e1ce34a3b38a4dcb80ffc4069b9312ac2023-11-20T04:48:27ZengMDPI AGNutrients2072-66432020-06-01126188410.3390/nu12061884Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric CancerKota Shigeto0Takumi Kawaguchi1Shunji Koya2Keisuke Hirota3Toshimitsu Tanaka4Sachiko Nagasu5Masaru Fukahori6Tomoyuki Ushijima7Hiroo Matsuse8Keisuke Miwa9Koji Nagafuji10Takuji Torimura11Multidisciplinary Treatment Cancer Center, Kurume University Hospital, Kurume 830-0011, JapanDivision of Gastroenterology, Kurume University School of Medicine, Kurume 830-0011, JapanDivision of Rehabilitation, Kurume University Hospital, Kurume 830-0011, JapanDivision of Rehabilitation, Kurume University Hospital, Kurume 830-0011, JapanMultidisciplinary Treatment Cancer Center, Kurume University Hospital, Kurume 830-0011, JapanMultidisciplinary Treatment Cancer Center, Kurume University Hospital, Kurume 830-0011, JapanMultidisciplinary Treatment Cancer Center, Kurume University Hospital, Kurume 830-0011, JapanMultidisciplinary Treatment Cancer Center, Kurume University Hospital, Kurume 830-0011, JapanDivision of Rehabilitation, Kurume University Hospital, Kurume 830-0011, JapanMultidisciplinary Treatment Cancer Center, Kurume University Hospital, Kurume 830-0011, JapanMultidisciplinary Treatment Cancer Center, Kurume University Hospital, Kurume 830-0011, JapanDivision of Gastroenterology, Kurume University School of Medicine, Kurume 830-0011, JapanWe aimed to investigate the impact of muscle atrophy and the neutrophil-to-lymphocyte ratio (NLR), a sub-clinical biomarker of inflammation and nutrition, on the prognosis of patients with unresectable advanced gastric cancer. We retrospectively enrolled 109 patients with stage IV gastric cancer (median age 69 years; female/male 22%/78%; median observational period 261 days). Independent factors and profiles for overall survival (OS) were determined by Cox regression analysis and decision-tree analysis, respectively. OS was calculated using the Kaplan–Meier method. The prevalence of muscle atrophy was 82.6% and the median NLR was 3.15. In Cox regression analysis, none of factors were identified as an independent factor for survival. The decision-tree analysis revealed that the most favorable prognostic profile was non-muscle atrophy (OS rate 36.8%). The most unfavorable prognostic profile was the combination of muscle atrophy and high NLR (OS rate 19.6%). The OS rate was significantly lower in patients with muscle atrophy and high NLR than in patients with non-muscle atrophy (1-year survival rate 28.5% vs. 54.7%; log-rank test <i>p</i> = 0.0014). In conclusion, “muscle atrophy and high NLR” was a prognostic profile for patients with stage IV gastric cancer. Thus, the assessment of muscle mass, subclinical inflammation, and malnutrition may be important for the management of patients with stage IV gastric cancer.https://www.mdpi.com/2072-6643/12/6/1884malnutritionskeletal muscleinflammationstomach cancermortality |
| spellingShingle | Kota Shigeto Takumi Kawaguchi Shunji Koya Keisuke Hirota Toshimitsu Tanaka Sachiko Nagasu Masaru Fukahori Tomoyuki Ushijima Hiroo Matsuse Keisuke Miwa Koji Nagafuji Takuji Torimura Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer Nutrients malnutrition skeletal muscle inflammation stomach cancer mortality |
| title | Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer |
| title_full | Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer |
| title_fullStr | Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer |
| title_full_unstemmed | Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer |
| title_short | Profiles Combining Muscle Atrophy and Neutrophil-to-Lymphocyte Ratio Are Associated with Prognosis of Patients with Stage IV Gastric Cancer |
| title_sort | profiles combining muscle atrophy and neutrophil to lymphocyte ratio are associated with prognosis of patients with stage iv gastric cancer |
| topic | malnutrition skeletal muscle inflammation stomach cancer mortality |
| url | https://www.mdpi.com/2072-6643/12/6/1884 |
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