Conjugation of Synthetic Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields Active and Stable Antimicrobials

Conjugation of Synthetic Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields Active and Stable Antimicrobials

Coupling functional moieties to lantibiotics offers exciting opportunities to produce novel derivatives with desirable properties enabling new functions and applications. Here, five different synthetic hydrophobic polyproline peptides were conjugated to either nisin AB (the first two rings of nisin)...

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Bibliographic Details
Main Authors: Jingjing Deng, Jakob H. Viel, Vladimir Kubyshkin, Nediljko Budisa, Oscar P. Kuipers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Microbiology
Subjects:
click chemistry
RiPPs
lantibiotics
nisin
polyproline peptides
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.575334/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.575334/full

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