Cisplatin-Induced Nausea and Vomiting: Effect of Herbal Medicines
Cisplatin is a chemotherapeutic agent that is widely used to treat various types of cancers. However, its side effects, most commonly nausea and vomiting, limit its widespread use. Although various drugs, such as ondansetron and aprepitant, are used to alleviate these side effects, their efficacy is...
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MDPI AG
2022-12-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/11/23/3395 |
| _version_ | 1827642657842659328 |
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| author | Yuchan Shin Bonglee Kim Woojin Kim |
| author_facet | Yuchan Shin Bonglee Kim Woojin Kim |
| author_sort | Yuchan Shin |
| collection | DOAJ |
| description | Cisplatin is a chemotherapeutic agent that is widely used to treat various types of cancers. However, its side effects, most commonly nausea and vomiting, limit its widespread use. Although various drugs, such as ondansetron and aprepitant, are used to alleviate these side effects, their efficacy is still debated. This review aims to summarize the results of 14 studies on the effects of seven single herbal extracts, one multiple herbal extract, and one ginger sub-component (i.e., [6]-gingerol) on cisplatin-induced nausea and vomiting. The results of the included studies were subdivided into four categories: kaolin consumption, retching and vomiting, food intake, and weight loss. Most studies used rodents, whereas four studies used minks or pigeons. The doses of cisplatin used in the studies varied from 3 mg/kg to 7.5 mg/kg, and only a single injection was used. Nine studies analyzed the mechanisms of action of herbal medicines and assessed the involvement of neurotransmitters, cytokines, enzymes, and various hematological parameters. Although further research is needed, this review suggests herbal medicine as a viable treatment option for cisplatin-induced neuropathic pain. |
| first_indexed | 2024-03-09T17:35:18Z |
| format | Article |
| id | doaj.art-e1d1cbdbcf894336a76967eb6923d183 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-09T17:35:18Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-e1d1cbdbcf894336a76967eb6923d1832023-11-24T11:57:16ZengMDPI AGPlants2223-77472022-12-011123339510.3390/plants11233395Cisplatin-Induced Nausea and Vomiting: Effect of Herbal MedicinesYuchan Shin0Bonglee Kim1Woojin Kim2Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaKorean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaCisplatin is a chemotherapeutic agent that is widely used to treat various types of cancers. However, its side effects, most commonly nausea and vomiting, limit its widespread use. Although various drugs, such as ondansetron and aprepitant, are used to alleviate these side effects, their efficacy is still debated. This review aims to summarize the results of 14 studies on the effects of seven single herbal extracts, one multiple herbal extract, and one ginger sub-component (i.e., [6]-gingerol) on cisplatin-induced nausea and vomiting. The results of the included studies were subdivided into four categories: kaolin consumption, retching and vomiting, food intake, and weight loss. Most studies used rodents, whereas four studies used minks or pigeons. The doses of cisplatin used in the studies varied from 3 mg/kg to 7.5 mg/kg, and only a single injection was used. Nine studies analyzed the mechanisms of action of herbal medicines and assessed the involvement of neurotransmitters, cytokines, enzymes, and various hematological parameters. Although further research is needed, this review suggests herbal medicine as a viable treatment option for cisplatin-induced neuropathic pain.https://www.mdpi.com/2223-7747/11/23/3395cisplatinfeeding disorderherbal medicinesnauseavomiting |
| spellingShingle | Yuchan Shin Bonglee Kim Woojin Kim Cisplatin-Induced Nausea and Vomiting: Effect of Herbal Medicines Plants cisplatin feeding disorder herbal medicines nausea vomiting |
| title | Cisplatin-Induced Nausea and Vomiting: Effect of Herbal Medicines |
| title_full | Cisplatin-Induced Nausea and Vomiting: Effect of Herbal Medicines |
| title_fullStr | Cisplatin-Induced Nausea and Vomiting: Effect of Herbal Medicines |
| title_full_unstemmed | Cisplatin-Induced Nausea and Vomiting: Effect of Herbal Medicines |
| title_short | Cisplatin-Induced Nausea and Vomiting: Effect of Herbal Medicines |
| title_sort | cisplatin induced nausea and vomiting effect of herbal medicines |
| topic | cisplatin feeding disorder herbal medicines nausea vomiting |
| url | https://www.mdpi.com/2223-7747/11/23/3395 |
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