MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis
Abstract Gynecological and breast tumors are one of the main causes of cancer-related mortalities among women. Despite recent advances in diagnostic and therapeutic methods, tumor relapse is observed in a high percentage of these patients due to the treatment failure. Late diagnosis in advanced tumo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01329-7 |
| _version_ | 1797577272849334272 |
|---|---|
| author | Negin Taghehchian Malihe Lotfi Amir Sadra Zangouei Iman Akhlaghipour Meysam Moghbeli |
| author_facet | Negin Taghehchian Malihe Lotfi Amir Sadra Zangouei Iman Akhlaghipour Meysam Moghbeli |
| author_sort | Negin Taghehchian |
| collection | DOAJ |
| description | Abstract Gynecological and breast tumors are one of the main causes of cancer-related mortalities among women. Despite recent advances in diagnostic and therapeutic methods, tumor relapse is observed in a high percentage of these patients due to the treatment failure. Late diagnosis in advanced tumor stages is one of the main reasons for the treatment failure and recurrence in these tumors. Therefore, it is necessary to assess the molecular mechanisms involved in progression of these tumors to introduce the efficient early diagnostic markers. Fokhead Box (FOX) is a family of transcription factors with a key role in regulation of a wide variety of cellular mechanisms. Deregulation of FOX proteins has been observed in different cancers. MicroRNAs (miRNAs) as a group of non-coding RNAs have important roles in post-transcriptional regulation of the genes involved in cellular mechanisms. They are also the non-invasive diagnostic markers due to their high stability in body fluids. Considering the importance of FOX proteins in the progression of breast and gynecological tumors, we investigated the role of miRNAs in regulation of the FOX proteins in these tumors. MicroRNAs were mainly involved in progression of these tumors through FOXM, FOXP, and FOXO. The present review paves the way to suggest a non-invasive diagnostic panel marker based on the miRNAs/FOX axis in breast and gynecological cancers. |
| first_indexed | 2024-03-10T22:06:49Z |
| format | Article |
| id | doaj.art-e1d312afc257454ebed620f3266e179c |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-10T22:06:49Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-e1d312afc257454ebed620f3266e179c2023-11-19T12:47:45ZengBMCEuropean Journal of Medical Research2047-783X2023-09-0128111410.1186/s40001-023-01329-7MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasisNegin Taghehchian0Malihe Lotfi1Amir Sadra Zangouei2Iman Akhlaghipour3Meysam Moghbeli4Medical Genetics Research Center, Mashhad University of Medical SciencesMedical Genetics Research Center, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesMedical Genetics Research Center, Mashhad University of Medical SciencesAbstract Gynecological and breast tumors are one of the main causes of cancer-related mortalities among women. Despite recent advances in diagnostic and therapeutic methods, tumor relapse is observed in a high percentage of these patients due to the treatment failure. Late diagnosis in advanced tumor stages is one of the main reasons for the treatment failure and recurrence in these tumors. Therefore, it is necessary to assess the molecular mechanisms involved in progression of these tumors to introduce the efficient early diagnostic markers. Fokhead Box (FOX) is a family of transcription factors with a key role in regulation of a wide variety of cellular mechanisms. Deregulation of FOX proteins has been observed in different cancers. MicroRNAs (miRNAs) as a group of non-coding RNAs have important roles in post-transcriptional regulation of the genes involved in cellular mechanisms. They are also the non-invasive diagnostic markers due to their high stability in body fluids. Considering the importance of FOX proteins in the progression of breast and gynecological tumors, we investigated the role of miRNAs in regulation of the FOX proteins in these tumors. MicroRNAs were mainly involved in progression of these tumors through FOXM, FOXP, and FOXO. The present review paves the way to suggest a non-invasive diagnostic panel marker based on the miRNAs/FOX axis in breast and gynecological cancers.https://doi.org/10.1186/s40001-023-01329-7Gynecological cancerBreast cancermiRNAsFOXDiagnosis |
| spellingShingle | Negin Taghehchian Malihe Lotfi Amir Sadra Zangouei Iman Akhlaghipour Meysam Moghbeli MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis European Journal of Medical Research Gynecological cancer Breast cancer miRNAs FOX Diagnosis |
| title | MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis |
| title_full | MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis |
| title_fullStr | MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis |
| title_full_unstemmed | MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis |
| title_short | MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis |
| title_sort | micrornas as the critical regulators of forkhead box protein family during gynecological and breast tumor progression and metastasis |
| topic | Gynecological cancer Breast cancer miRNAs FOX Diagnosis |
| url | https://doi.org/10.1186/s40001-023-01329-7 |
| work_keys_str_mv | AT negintaghehchian micrornasasthecriticalregulatorsofforkheadboxproteinfamilyduringgynecologicalandbreasttumorprogressionandmetastasis AT malihelotfi micrornasasthecriticalregulatorsofforkheadboxproteinfamilyduringgynecologicalandbreasttumorprogressionandmetastasis AT amirsadrazangouei micrornasasthecriticalregulatorsofforkheadboxproteinfamilyduringgynecologicalandbreasttumorprogressionandmetastasis AT imanakhlaghipour micrornasasthecriticalregulatorsofforkheadboxproteinfamilyduringgynecologicalandbreasttumorprogressionandmetastasis AT meysammoghbeli micrornasasthecriticalregulatorsofforkheadboxproteinfamilyduringgynecologicalandbreasttumorprogressionandmetastasis |