Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation
Microbial keratitis are severe infectionsgenerally linked to risk factors. High-doses antibiotic eye-drops could be required to avoid severe complications. In such cases, hospital pharmacists are in charge of their production given the lack of such formulations on the market. The stability of these...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2018-11-01
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| Series: | Pharmaceutical Technology in Hospital Pharmacy |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pthp-2018-0025 |
| _version_ | 1819124216593645568 |
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| author | Gautier Eric Saillard Justine Deshayes Caroline Vrignaud Sandy Lagarce Frederic Briot Thomas |
| author_facet | Gautier Eric Saillard Justine Deshayes Caroline Vrignaud Sandy Lagarce Frederic Briot Thomas |
| author_sort | Gautier Eric |
| collection | DOAJ |
| description | Microbial keratitis are severe infectionsgenerally linked to risk factors. High-doses antibiotic eye-drops could be required to avoid severe complications. In such cases, hospital pharmacists are in charge of their production given the lack of such formulations on the market. The stability of these antibiotic eye-drops is generally limited to a couple of days and publications generally do not describe addition of microbial preservatives even though it is a European Pharmacopeia requirement. The aim of this study was to describe a new ceftazidime eye-drops formulation at 50 mg/mL with a antimicrobial additive, benzalkonium chloride at 0.04 mg/mL. |
| first_indexed | 2024-12-22T07:20:43Z |
| format | Article |
| id | doaj.art-e1d634bec6e449879ca03bcbd2598b46 |
| institution | Directory Open Access Journal |
| issn | 2365-2411 2365-242X |
| language | English |
| last_indexed | 2024-12-22T07:20:43Z |
| publishDate | 2018-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pharmaceutical Technology in Hospital Pharmacy |
| spelling | doaj.art-e1d634bec6e449879ca03bcbd2598b462022-12-21T18:34:16ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2018-11-013421922610.1515/pthp-2018-0025Stability of a 50 mg/mL Ceftazidime Eye-Drops FormulationGautier Eric0Saillard Justine1Deshayes Caroline2Vrignaud Sandy3Lagarce Frederic4Briot Thomas5Pharmacy, University Hospital of Angers, Angers, FrancePharmacy, University Hospital of Angers, Angers, FranceLaboratoire SiFCIR UPRES EA2647/USC INRA 1330, SFR 4207 QUASAV, UFR Sciences, Université Angers, Angers, FrancePharmacy, University Hospital of Angers, Angers, FrancePharmacy, University Hospital of Angers, Angers, FrancePharmacy, University Hospital of Angers, Angers, FranceMicrobial keratitis are severe infectionsgenerally linked to risk factors. High-doses antibiotic eye-drops could be required to avoid severe complications. In such cases, hospital pharmacists are in charge of their production given the lack of such formulations on the market. The stability of these antibiotic eye-drops is generally limited to a couple of days and publications generally do not describe addition of microbial preservatives even though it is a European Pharmacopeia requirement. The aim of this study was to describe a new ceftazidime eye-drops formulation at 50 mg/mL with a antimicrobial additive, benzalkonium chloride at 0.04 mg/mL.https://doi.org/10.1515/pthp-2018-0025ceftazidimeeyedropsstabilityhplc uvstability indicating method |
| spellingShingle | Gautier Eric Saillard Justine Deshayes Caroline Vrignaud Sandy Lagarce Frederic Briot Thomas Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation Pharmaceutical Technology in Hospital Pharmacy ceftazidime eyedrops stability hplc uv stability indicating method |
| title | Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation |
| title_full | Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation |
| title_fullStr | Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation |
| title_full_unstemmed | Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation |
| title_short | Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation |
| title_sort | stability of a 50 mg ml ceftazidime eye drops formulation |
| topic | ceftazidime eyedrops stability hplc uv stability indicating method |
| url | https://doi.org/10.1515/pthp-2018-0025 |
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