Early Intervention via Stimulation of the Medial Septal Nucleus Improves Cognition and Alters Markers of Epileptogenesis in Pilocarpine-Induced Epilepsy

Early Intervention via Stimulation of the Medial Septal Nucleus Improves Cognition and Alters Markers of Epileptogenesis in Pilocarpine-Induced Epilepsy

Over one-third of patients with temporal lobe epilepsy are refractory to medication. In addition, anti-epileptic drugs often exacerbate cognitive comorbidities. Neuromodulation is an FDA treatment for refractory epilepsy, but patients often wait >20 years for a surgical referral for resection...

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Bibliographic Details
Main Authors: Ali Izadi, Amber Schedlbauer, Katelynn Ondek, Gregory Disse, Arne D. Ekstrom, Stephen L. Cowen, Kiarash Shahlaie, Gene G. Gurkoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neurology
Subjects:
deep brain stimulation
temporal lobe epilepsy
theta oscillations
cognition
pilocarpine
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.708957/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.708957/full

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