Creating Designer Engineered Extracellular Vesicles for Diverse Ligand Display, Target Recognition, and Controlled Protein Loading and Delivery

Creating Designer Engineered Extracellular Vesicles for Diverse Ligand Display, Target Recognition, and Controlled Protein Loading and Delivery

Abstract Efficient and targeted delivery of therapeutic agents remains a bottleneck in modern medicine. Here, biochemical engineering approaches to advance the repurposing of extracellular vesicles (EVs) as drug delivery vehicles are explored. Targeting ligands such as the sugar GalNAc are displayed...

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Bibliographic Details
Main Authors: Alena Ivanova, Lukas Badertscher, Gwen O'Driscoll, Joakim Bergman, Euan Gordon, Anders Gunnarsson, Camilla Johansson, Michael J. Munson, Cristiana Spinelli, Sara Torstensson, Liisa Vilén, Andrei Voirel, John Wiseman, Janusz Rak, Niek Dekker, Elisa Lázaro‐Ibáñez
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
exosomes
extracellular vesicles
genetic engineering
protein loading
targeting
Online Access:https://doi.org/10.1002/advs.202304389

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