Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles
Liposomes are consolidated and attractive biomimetic nanocarriers widely used in the field of drug delivery. The structural versatility of liposomes has been exploited for the development of various carriers for the topical or systemic delivery of drugs and bioactive molecules, with the possibility...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/7/1027 |
| _version_ | 1797539990375235584 |
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| author | Vincenzo De Leo Francesco Milano Angela Agostiano Lucia Catucci |
| author_facet | Vincenzo De Leo Francesco Milano Angela Agostiano Lucia Catucci |
| author_sort | Vincenzo De Leo |
| collection | DOAJ |
| description | Liposomes are consolidated and attractive biomimetic nanocarriers widely used in the field of drug delivery. The structural versatility of liposomes has been exploited for the development of various carriers for the topical or systemic delivery of drugs and bioactive molecules, with the possibility of increasing their bioavailability and stability, and modulating and directing their release, while limiting the side effects at the same time. Nevertheless, first-generation vesicles suffer from some limitations including physical instability, short in vivo circulation lifetime, reduced payload, uncontrolled release properties, and low targeting abilities. Therefore, liposome preparation technology soon took advantage of the possibility of improving vesicle performance using both natural and synthetic polymers. Polymers can easily be synthesized in a controlled manner over a wide range of molecular weights and in a low dispersity range. Their properties are widely tunable and therefore allow the low chemical versatility typical of lipids to be overcome. Moreover, depending on their structure, polymers can be used to create a simple covering on the liposome surface or to intercalate in the phospholipid bilayer to give rise to real hybrid structures. This review illustrates the main strategies implemented in the field of polymer/liposome assembly for drug delivery, with a look at the most recent publications without neglecting basic concepts for a simple and complete understanding by the reader. |
| first_indexed | 2024-03-10T12:53:41Z |
| format | Article |
| id | doaj.art-e1d977668e704fe5be2f0475dd8a743e |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T12:53:41Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-e1d977668e704fe5be2f0475dd8a743e2023-11-21T12:06:53ZengMDPI AGPolymers2073-43602021-03-01137102710.3390/polym13071027Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid VesiclesVincenzo De Leo0Francesco Milano1Angela Agostiano2Lucia Catucci3Department of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, ItalyIstituto di Scienze delle Produzioni Alimentari (ISPA), Consiglio Nazionale delle Ricerche (CNR), S.P. Lecce-Monteroni, Ecotekne, 73100 Lecce, ItalyDepartment of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, ItalyDepartment of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, ItalyLiposomes are consolidated and attractive biomimetic nanocarriers widely used in the field of drug delivery. The structural versatility of liposomes has been exploited for the development of various carriers for the topical or systemic delivery of drugs and bioactive molecules, with the possibility of increasing their bioavailability and stability, and modulating and directing their release, while limiting the side effects at the same time. Nevertheless, first-generation vesicles suffer from some limitations including physical instability, short in vivo circulation lifetime, reduced payload, uncontrolled release properties, and low targeting abilities. Therefore, liposome preparation technology soon took advantage of the possibility of improving vesicle performance using both natural and synthetic polymers. Polymers can easily be synthesized in a controlled manner over a wide range of molecular weights and in a low dispersity range. Their properties are widely tunable and therefore allow the low chemical versatility typical of lipids to be overcome. Moreover, depending on their structure, polymers can be used to create a simple covering on the liposome surface or to intercalate in the phospholipid bilayer to give rise to real hybrid structures. This review illustrates the main strategies implemented in the field of polymer/liposome assembly for drug delivery, with a look at the most recent publications without neglecting basic concepts for a simple and complete understanding by the reader.https://www.mdpi.com/2073-4360/13/7/1027liposomespolymersliposome surface modificationhybrid vesiclesphysicochemical stabilityencapsulation efficiency |
| spellingShingle | Vincenzo De Leo Francesco Milano Angela Agostiano Lucia Catucci Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles Polymers liposomes polymers liposome surface modification hybrid vesicles physicochemical stability encapsulation efficiency |
| title | Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles |
| title_full | Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles |
| title_fullStr | Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles |
| title_full_unstemmed | Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles |
| title_short | Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles |
| title_sort | recent advancements in polymer liposome assembly for drug delivery from surface modifications to hybrid vesicles |
| topic | liposomes polymers liposome surface modification hybrid vesicles physicochemical stability encapsulation efficiency |
| url | https://www.mdpi.com/2073-4360/13/7/1027 |
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