Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis

Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis

Abstract Background Extracellular vesicles (EVs) are recognized as novel cell-free therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health problem. Herein, we show that EVs from pan peroxisome proliferator-activated receptor agonist-primed induced mesenchymal stem cell (pan PPAR...

Full description

Bibliographic Details
Main Authors:	Jimin Kim, Seul Ki Lee, Seon-Yeong Jeong, Hye Jin Cho, Joonghoon Park, Tae Min Kim, Soo Kim
Format:	Article
Language:	English
Published:	BMC 2021-11-01
Series:	Journal of Nanobiotechnology
Subjects:	Non-alcoholic steatohepatitis Induced mesenchymal stem cells Extracellular vesicles Steatosis Inflammation Regeneration
Online Access:	https://doi.org/10.1186/s12951-021-01120-y

Similar Items

Lipidomic identification of urinary extracellular vesicles for non-alcoholic steatohepatitis diagnosis
by: Qingfu Zhu, et al.
Published: (2022-07-01)

Pan PPAR agonist stimulation of induced MSCs produces extracellular vesicles with enhanced renoprotective effect for acute kidney injury
by: Hongduk Kim, et al.
Published: (2024-01-01)

Non-alcoholic Steatohepatitis: An Overview
by: Allison Shifflet, et al.
Published: (2009-01-01)

Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice
by: Jimin Kim, et al.
Published: (2022-12-01)

Emerging role of mesenchymal stem cell-derived extracellular vesicles in periodontal regeneration
by: Yaldasadat Anvari, DDS, et al.
Published: (2024-04-01)

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins
by: Robert Mitchell, et al.
Published: (2019-04-01)

Extracellular Vesicles as Drivers of Non-Alcoholic Fatty Liver Disease: Small Particles with Big Impact
by: David Højland Ipsen, et al.
Published: (2021-01-01)

Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration
by: Liangrui Chen, et al.
Published: (2023-02-01)

Extracellular Vesicles for Dental Pulp and Periodontal Regeneration
by: Hongbin Lai, et al.
Published: (2023-01-01)

Approaches of Mesenchymal Stem Cells Derived- Extracellular Vesicles in Knee Osteoarthritis Defects
by: Maryan Talebi Jouybari, et al.
Published: (2024-02-01)

Extracellular vesicles released by steatotic hepatocytes alter adipocyte metabolism
by: J.E. Mleczko, et al.
Published: (2022-02-01)

Intra and inter-organ communication through extracellular vesicles in obesity: functional role of obesesomes and steatosomes
by: N. Lago-Baameiro, et al.
Published: (2025-02-01)

Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo
by: Bilal Mir, et al.
Published: (2020-07-01)

Mesenchymal stem cell-derived extracellular vesicles for treatment of bone loss within periodontitis in pre-clinical animal models: a meta-analysis
by: Huan Zhou, et al.
Published: (2023-09-01)

The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications
by: James Jabalee, et al.
Published: (2018-08-01)

Double Trouble: How Microbiome Dysbiosis and Mitochondrial Dysfunction Drive Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
by: Wesam Bahitham, et al.
Published: (2024-02-01)

Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure
by: Jie Wang, et al.
Published: (2017-06-01)

Biomaterials constructed for MSC-derived extracellular vesicle loading and delivery—a promising method for tissue regeneration
by: Yu Lu, et al.
Published: (2022-08-01)

Extracellular Vesicles From TNFα Preconditioned MSCs: Effects on Immunomodulation and Bone Regeneration
by: Miya Kang, et al.
Published: (2022-05-01)

Improvement of androgenic alopecia by extracellular vesicles secreted from hyaluronic acid-stimulated induced mesenchymal stem cells
by: Hyun Geun Oh, et al.
Published: (2024-09-01)

Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy
by: George Chigozie Njoku, et al.
Published: (2025-03-01)

The interactions between extracellular vesicles and mesenchymal stem cells: Their potential roles in osteoarthritis development and cartilage repair
by: Qiong Yang, et al.
Published: (2022-12-01)

Baseline Tyrosine Level Is Associated with Dynamic Changes in FAST Score in NAFLD Patients under Lifestyle Modification
by: Hwi Young Kim, et al.
Published: (2023-03-01)

Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential
by: Dao-Kun Deng, et al.
Published: (2022-12-01)

Ultrasonication outperforms electroporation for extracellular vesicle cargo depletion
by: Yundi Chen, et al.
Published: (2024-12-01)

Prevalence of metabolic dysfunction-associated steatotic liver disease and steatohepatitis in Türkiye: A forensic autopsy study
by: Ilkay Ergenc, et al.
Published: (2024-08-01)

Bone-Targeting Peptide and RNF146 Modified Apoptotic Extracellular Vesicles Alleviate Osteoporosis
by: Gui L, et al.
Published: (2024-01-01)

Bone Regeneration Improves with Mesenchymal Stem Cell Derived Extracellular Vesicles (EVs) Combined with Scaffolds: A Systematic Review
by: Federica Re, et al.
Published: (2021-06-01)

Hyaluronic acid stimulation of stem cells for cardiac repair: a cell-free strategy for myocardial infarct
by: Seon-Yeong Jeong, et al.
Published: (2024-04-01)

The role of small extracellular vesicles and microRNA as their cargo in the spinal cord injury pathophysiology and therapy
by: Kristyna Sintakova, et al.
Published: (2024-05-01)

Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling
by: Rebecca S. Aguirre, et al.
Published: (2022-09-01)

Multifunctional extracellular vesicles and edaravone-loaded scaffolds for kidney tissue regeneration by activating GDNF/RET pathway
by: Seung Yeon Lee, et al.
Published: (2024-10-01)

The long‐term protective effects of neonatal administration of curcumin against nonalcoholic steatohepatitis in high‐fructose‐fed adolescent rats
by: Kasimu G. Ibrahim, et al.
Published: (2019-03-01)

Bioengineering extracellular vesicle cargo for optimal therapeutic efficiency
by: Charlotte A. René, et al.
Published: (2024-06-01)

Steatosis and steatohepatitis found in adults after death due to non-burn trauma
by: Paulo Reis-Júnior, et al.
Published: (2019-10-01)

Thrombin-preconditioned mesenchymal stromal cell-derived extracellular vesicles attenuate experimental necrotizing enterocolitis
by: Sein Hwang, et al.
Published: (2025-02-01)

Metabolic preconditions for the formation and progression of steatohepatitis of alcoholic, mixed, non-alcoholic aetiology and their comorbidity with obesity and anaemic conditions
by: T. Antofiichuk, et al.
Published: (2023-05-01)

β-Hydroxyphosphocarnitine modifies fibrosis, steatosis and improves liver function in non-alcoholic steatohepatitis induced in rats
by: Janet Sánchez-Quevedo, et al.
Published: (2022-09-01)

Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications
by: Dimitrios Tsiapalis, et al.
Published: (2020-04-01)

microRNAs delivered by small extracellular vesicles in MSCs as an emerging tool for bone regeneration
by: Runyuan Liu, et al.
Published: (2023-08-01)