The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression
Post-stroke depression (PSD) is the most common and serious sequelae of stroke. Approximately 33% of stroke survivors were affected by PSD. However, many issues (e.g., incidence, diagnostic marker, and risk factor) related to PSD remained unclear. The “monoamine hypothesis” is a significant hypothes...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.871754/full |
| _version_ | 1818478807823155200 |
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| author | Simeng Gu Simeng Gu Zhengming He Qiuyue Xu Jie Dong Tingwei Xiao Fei Liang Xianjun Ma Fushun Wang Jason H. Huang Jason H. Huang |
| author_facet | Simeng Gu Simeng Gu Zhengming He Qiuyue Xu Jie Dong Tingwei Xiao Fei Liang Xianjun Ma Fushun Wang Jason H. Huang Jason H. Huang |
| author_sort | Simeng Gu |
| collection | DOAJ |
| description | Post-stroke depression (PSD) is the most common and serious sequelae of stroke. Approximately 33% of stroke survivors were affected by PSD. However, many issues (e.g., incidence, diagnostic marker, and risk factor) related to PSD remained unclear. The “monoamine hypothesis” is a significant hypothesis for depression, which suggests that three monoamines play a key role in depression. Therefore, most current antidepressants are developed to modulate the monoamines on PSD treatment, and these antidepressants have good effects on patients with PSD. However, the potential mechanisms of three monoamines in PSD are still unclear. Previously, we proposed “three primary emotions,” which suggested a new model of basic emotions based on the three monoamines. It may provide a new way for PSD treatment. In addition, recent studies have found that monoamine-related emotional intervention also showed potential effects in the treatment and prevention of PSD. This study discusses these issues and attempts to provide a prospect for future research on PSD. |
| first_indexed | 2024-12-10T09:52:44Z |
| format | Article |
| id | doaj.art-e1d9ef41f7ae4e6182be4dc9a4c52ad4 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-10T09:52:44Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-e1d9ef41f7ae4e6182be4dc9a4c52ad42022-12-22T01:53:37ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-04-011310.3389/fpsyt.2022.871754871754The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke DepressionSimeng Gu0Simeng Gu1Zhengming He2Qiuyue Xu3Jie Dong4Tingwei Xiao5Fei Liang6Xianjun Ma7Fushun Wang8Jason H. Huang9Jason H. Huang10Department of Psychology, Jiangsu University Medical School, Zhenjiang, ChinaInstitute of Brain and Psychological Science, Sichuan Normal University, Chengdu, ChinaInstitute of Brain and Psychological Science, Sichuan Normal University, Chengdu, ChinaDepartment of Nurse, Nanjing University of Chinese Medicine, Nanjing, ChinaInstitute of Brain and Psychological Science, Sichuan Normal University, Chengdu, ChinaInstitute of Brain and Psychological Science, Sichuan Normal University, Chengdu, ChinaInstitute of Brain and Psychological Science, Sichuan Normal University, Chengdu, ChinaSection of Brain Diseases, Department of Neurology, Lianyungang Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Lianyungang, ChinaInstitute of Brain and Psychological Science, Sichuan Normal University, Chengdu, ChinaDepartment of Neurosurgery, Baylor Scott & White Health, Temple, TX, United StatesDepartment of Surgery, Texas A&M University College of Medicine, Temple, TX, United StatesPost-stroke depression (PSD) is the most common and serious sequelae of stroke. Approximately 33% of stroke survivors were affected by PSD. However, many issues (e.g., incidence, diagnostic marker, and risk factor) related to PSD remained unclear. The “monoamine hypothesis” is a significant hypothesis for depression, which suggests that three monoamines play a key role in depression. Therefore, most current antidepressants are developed to modulate the monoamines on PSD treatment, and these antidepressants have good effects on patients with PSD. However, the potential mechanisms of three monoamines in PSD are still unclear. Previously, we proposed “three primary emotions,” which suggested a new model of basic emotions based on the three monoamines. It may provide a new way for PSD treatment. In addition, recent studies have found that monoamine-related emotional intervention also showed potential effects in the treatment and prevention of PSD. This study discusses these issues and attempts to provide a prospect for future research on PSD.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.871754/fullpost-stroke depression5-Hydroxytryptaminemonoamine hypothesisthree primary emotionsemotional intervention |
| spellingShingle | Simeng Gu Simeng Gu Zhengming He Qiuyue Xu Jie Dong Tingwei Xiao Fei Liang Xianjun Ma Fushun Wang Jason H. Huang Jason H. Huang The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression Frontiers in Psychiatry post-stroke depression 5-Hydroxytryptamine monoamine hypothesis three primary emotions emotional intervention |
| title | The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression |
| title_full | The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression |
| title_fullStr | The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression |
| title_full_unstemmed | The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression |
| title_short | The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression |
| title_sort | relationship between 5 hydroxytryptamine and its metabolite changes with post stroke depression |
| topic | post-stroke depression 5-Hydroxytryptamine monoamine hypothesis three primary emotions emotional intervention |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.871754/full |
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