Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE<sup>−/−</sup> Mice
Capsanthin is a red pigment and the major carotenoid component of red paprika (<i>Capsicum annuum</i> L.). However, its role in atherosclerosis is yet to be fully elucidated. This study investigated the role of dietary capsanthin in vascular inflammation in atherosclerotic mice. We evalu...
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MDPI AG
2022-07-01
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1780 |
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| author | Sungmin Kim Yu-Ran Lee Eun-Ok Lee Hao Jin Yeon-Hee Choi Hee-Kyoung Joo Byeong-Hwa Jeon |
| author_facet | Sungmin Kim Yu-Ran Lee Eun-Ok Lee Hao Jin Yeon-Hee Choi Hee-Kyoung Joo Byeong-Hwa Jeon |
| author_sort | Sungmin Kim |
| collection | DOAJ |
| description | Capsanthin is a red pigment and the major carotenoid component of red paprika (<i>Capsicum annuum</i> L.). However, its role in atherosclerosis is yet to be fully elucidated. This study investigated the role of dietary capsanthin in vascular inflammation in atherosclerotic mice. We evaluated the anti-atherosclerotic effects of daily oral administration of capsanthin (0.5 mg/kg of body weight/day) in apolipoprotein E-deficient (ApoE<sup>−/−</sup>) mice fed a Western-type diet (WD). Capsanthin treatment inhibited vascular cell adhesion molecule 1 expression and nuclear factor-κB ser536 phosphorylation in tumor necrosis factor-α-stimulated cultured endothelial cells. Dietary capsanthin significantly inhibited the WD-induced elevation in the plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride in mice. Interestingly, capsanthin reduced aortic plaque formation and VCAM-1 expression, which is vascular inflammation, in atherosclerotic mice. In addition, the neutrophil–lymphocyte ratio, a systemic inflammatory marker, was inhibited in capsanthin-treated mice. Furthermore, capsanthin significantly reduced the levels of proinflammatory cytokines, such as TNF-α, interleukin-6, and monocyte chemoattractant protein-1, in the plasma of atherosclerotic mice. Collectively, our data demonstrate that dietary capsanthin plays a protective role against atherosclerosis in hyperlipidemic mice. This protective effect could be attributed to the anti-inflammatory properties of capsanthin. |
| first_indexed | 2024-03-09T04:41:26Z |
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| language | English |
| last_indexed | 2024-03-09T04:41:26Z |
| publishDate | 2022-07-01 |
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| series | Biomedicines |
| spelling | doaj.art-e1db8d01fdff405795ba62a102261e102023-12-03T13:21:18ZengMDPI AGBiomedicines2227-90592022-07-01108178010.3390/biomedicines10081780Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE<sup>−/−</sup> MiceSungmin Kim0Yu-Ran Lee1Eun-Ok Lee2Hao Jin3Yeon-Hee Choi4Hee-Kyoung Joo5Byeong-Hwa Jeon6Research Institute for Medical Sciences, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, KoreaResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, KoreaResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, KoreaResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, KoreaResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, KoreaResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, KoreaResearch Institute for Medical Sciences, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, KoreaCapsanthin is a red pigment and the major carotenoid component of red paprika (<i>Capsicum annuum</i> L.). However, its role in atherosclerosis is yet to be fully elucidated. This study investigated the role of dietary capsanthin in vascular inflammation in atherosclerotic mice. We evaluated the anti-atherosclerotic effects of daily oral administration of capsanthin (0.5 mg/kg of body weight/day) in apolipoprotein E-deficient (ApoE<sup>−/−</sup>) mice fed a Western-type diet (WD). Capsanthin treatment inhibited vascular cell adhesion molecule 1 expression and nuclear factor-κB ser536 phosphorylation in tumor necrosis factor-α-stimulated cultured endothelial cells. Dietary capsanthin significantly inhibited the WD-induced elevation in the plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride in mice. Interestingly, capsanthin reduced aortic plaque formation and VCAM-1 expression, which is vascular inflammation, in atherosclerotic mice. In addition, the neutrophil–lymphocyte ratio, a systemic inflammatory marker, was inhibited in capsanthin-treated mice. Furthermore, capsanthin significantly reduced the levels of proinflammatory cytokines, such as TNF-α, interleukin-6, and monocyte chemoattractant protein-1, in the plasma of atherosclerotic mice. Collectively, our data demonstrate that dietary capsanthin plays a protective role against atherosclerosis in hyperlipidemic mice. This protective effect could be attributed to the anti-inflammatory properties of capsanthin.https://www.mdpi.com/2227-9059/10/8/1780capsanthinatherosclerosisApoE<sup>−/−</sup> micevascular inflammation |
| spellingShingle | Sungmin Kim Yu-Ran Lee Eun-Ok Lee Hao Jin Yeon-Hee Choi Hee-Kyoung Joo Byeong-Hwa Jeon Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE<sup>−/−</sup> Mice Biomedicines capsanthin atherosclerosis ApoE<sup>−/−</sup> mice vascular inflammation |
| title | Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE<sup>−/−</sup> Mice |
| title_full | Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE<sup>−/−</sup> Mice |
| title_fullStr | Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE<sup>−/−</sup> Mice |
| title_full_unstemmed | Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE<sup>−/−</sup> Mice |
| title_short | Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE<sup>−/−</sup> Mice |
| title_sort | capsanthin inhibits atherosclerotic plaque formation and vascular inflammation in apoe sup sup mice |
| topic | capsanthin atherosclerosis ApoE<sup>−/−</sup> mice vascular inflammation |
| url | https://www.mdpi.com/2227-9059/10/8/1780 |
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