Limbal Stem Cells in Review
<!--[if gte mso 9]><xml> Normal 0 false false false MicrosoftInternetExplorer4 </xml><![endif]--><!--[if gte mso 9]><xml> </xml><![endif]--> <!--[if gte mso 10]> <styl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Knowledge E
2009-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Online Access: | http://www.jovr.ir/index.php/jovr/article/view/84 |
| _version_ | 1811192635248869376 |
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| author | Marzieh Ebrahimi Ehsan Taghi-Abadi Hossein Baharvand |
| author_facet | Marzieh Ebrahimi Ehsan Taghi-Abadi Hossein Baharvand |
| author_sort | Marzieh Ebrahimi |
| collection | DOAJ |
| description | <!--[if gte mso 9]><xml> Normal 0 false false false MicrosoftInternetExplorer4 </xml><![endif]--><!--[if gte mso 9]><xml> </xml><![endif]--> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <![endif]--> <p>The ocular surface consists of two distinct types of epithelial cells; conjunctival and corneal. Although anatomically continuous, these epithelia comprise two distinct cell populations. Corneal stem cells are located at the limbus. The microenvironment of the limbus is important in maintaining "stemness" of the stem cells and also acts as a barrier to conjunctival epithelial cells preventing them from migration onto the corneal surface. Damage to the limbus results in varying degrees of limbal stem cell deficiency with characteristic clinical features including conjunctivalization of the cornea. Regenerative management of corneal conjunctivalization utilizing stem cells comprises of two approaches; limbal auto- or allografts by using existing stem cells and induction and regeneration of ocular tissues from embryonic stem cells. Herein, we review stem cells and limbal stem cells in particular, types of epithelial cells in the cornea, markers of corneal epithelial cells in different stages, as well as the current approach to corneal epithelial regeneration.</p> |
| first_indexed | 2024-04-11T23:55:40Z |
| format | Article |
| id | doaj.art-e1dc7d90ce8d452a8c13e1fff03cbfc2 |
| institution | Directory Open Access Journal |
| issn | 2008-2010 2008-322X |
| language | English |
| last_indexed | 2024-04-11T23:55:40Z |
| publishDate | 2009-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-e1dc7d90ce8d452a8c13e1fff03cbfc22022-12-22T03:56:22ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2009-01-01414058Limbal Stem Cells in ReviewMarzieh EbrahimiEhsan Taghi-AbadiHossein Baharvand<!--[if gte mso 9]><xml> Normal 0 false false false MicrosoftInternetExplorer4 </xml><![endif]--><!--[if gte mso 9]><xml> </xml><![endif]--> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <![endif]--> <p>The ocular surface consists of two distinct types of epithelial cells; conjunctival and corneal. Although anatomically continuous, these epithelia comprise two distinct cell populations. Corneal stem cells are located at the limbus. The microenvironment of the limbus is important in maintaining "stemness" of the stem cells and also acts as a barrier to conjunctival epithelial cells preventing them from migration onto the corneal surface. Damage to the limbus results in varying degrees of limbal stem cell deficiency with characteristic clinical features including conjunctivalization of the cornea. Regenerative management of corneal conjunctivalization utilizing stem cells comprises of two approaches; limbal auto- or allografts by using existing stem cells and induction and regeneration of ocular tissues from embryonic stem cells. Herein, we review stem cells and limbal stem cells in particular, types of epithelial cells in the cornea, markers of corneal epithelial cells in different stages, as well as the current approach to corneal epithelial regeneration.</p>http://www.jovr.ir/index.php/jovr/article/view/84 |
| spellingShingle | Marzieh Ebrahimi Ehsan Taghi-Abadi Hossein Baharvand Limbal Stem Cells in Review Journal of Ophthalmic & Vision Research |
| title | Limbal Stem Cells in Review |
| title_full | Limbal Stem Cells in Review |
| title_fullStr | Limbal Stem Cells in Review |
| title_full_unstemmed | Limbal Stem Cells in Review |
| title_short | Limbal Stem Cells in Review |
| title_sort | limbal stem cells in review |
| url | http://www.jovr.ir/index.php/jovr/article/view/84 |
| work_keys_str_mv | AT marziehebrahimi limbalstemcellsinreview AT ehsantaghiabadi limbalstemcellsinreview AT hosseinbaharvand limbalstemcellsinreview |