Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases
The integrin family is involved in various biological functions, including cell proliferation, differentiation and migration, and also in the pathogenesis of disease. Integrins are multifunctional receptors that exist as heterodimers composed of α and β subunits and bind to various ligands, includin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1435 |
| _version_ | 1797487476007239680 |
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| author | Hiroko Ikeshima-Kataoka Chikatoshi Sugimoto Tatsuya Tsubokawa |
| author_facet | Hiroko Ikeshima-Kataoka Chikatoshi Sugimoto Tatsuya Tsubokawa |
| author_sort | Hiroko Ikeshima-Kataoka |
| collection | DOAJ |
| description | The integrin family is involved in various biological functions, including cell proliferation, differentiation and migration, and also in the pathogenesis of disease. Integrins are multifunctional receptors that exist as heterodimers composed of α and β subunits and bind to various ligands, including extracellular matrix (ECM) proteins; they are found in many animals, not only vertebrates (e.g., mouse, rat, and teleost fish), but also invertebrates (e.g., planarian flatworm, fruit fly, nematodes, and cephalopods), which are used for research on genetics and social behaviors or as models for human diseases. In the present paper, we describe the results of a phylogenetic tree analysis of the integrin family among these species. We summarize integrin signaling in teleost fish, which serves as an excellent model for the study of regenerative systems and possesses the ability for replacing missing tissues, especially in the central nervous system, which has not been demonstrated in mammals. In addition, functions of astrocytes and reactive astrocytes, which contain neuroprotective subpopulations that act in concert with the ECM proteins tenascin C and osteopontin via integrin are also reviewed. Drug development research using integrin as a therapeutic target could result in breakthroughs for the treatment of neurodegenerative diseases and brain injury in mammals. |
| first_indexed | 2024-03-09T23:48:13Z |
| format | Article |
| id | doaj.art-e1dd428f260a44daa39a6f9feaa15950 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:48:13Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e1dd428f260a44daa39a6f9feaa159502023-11-23T16:40:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-01233143510.3390/ijms23031435Integrin Signaling in the Central Nervous System in Animals and Human Brain DiseasesHiroko Ikeshima-Kataoka0Chikatoshi Sugimoto1Tatsuya Tsubokawa2Department of Biology, Keio University, 4-1-1, Hiyoshi, Kohoku-ku, Yokohama-shi 223-8521, JapanDepartment of Biology, Keio University, 4-1-1, Hiyoshi, Kohoku-ku, Yokohama-shi 223-8521, JapanDepartment of Biology, Keio University, 4-1-1, Hiyoshi, Kohoku-ku, Yokohama-shi 223-8521, JapanThe integrin family is involved in various biological functions, including cell proliferation, differentiation and migration, and also in the pathogenesis of disease. Integrins are multifunctional receptors that exist as heterodimers composed of α and β subunits and bind to various ligands, including extracellular matrix (ECM) proteins; they are found in many animals, not only vertebrates (e.g., mouse, rat, and teleost fish), but also invertebrates (e.g., planarian flatworm, fruit fly, nematodes, and cephalopods), which are used for research on genetics and social behaviors or as models for human diseases. In the present paper, we describe the results of a phylogenetic tree analysis of the integrin family among these species. We summarize integrin signaling in teleost fish, which serves as an excellent model for the study of regenerative systems and possesses the ability for replacing missing tissues, especially in the central nervous system, which has not been demonstrated in mammals. In addition, functions of astrocytes and reactive astrocytes, which contain neuroprotective subpopulations that act in concert with the ECM proteins tenascin C and osteopontin via integrin are also reviewed. Drug development research using integrin as a therapeutic target could result in breakthroughs for the treatment of neurodegenerative diseases and brain injury in mammals.https://www.mdpi.com/1422-0067/23/3/1435astrocyteaxonCNSinvertebratemammalmouse |
| spellingShingle | Hiroko Ikeshima-Kataoka Chikatoshi Sugimoto Tatsuya Tsubokawa Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases International Journal of Molecular Sciences astrocyte axon CNS invertebrate mammal mouse |
| title | Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases |
| title_full | Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases |
| title_fullStr | Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases |
| title_full_unstemmed | Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases |
| title_short | Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases |
| title_sort | integrin signaling in the central nervous system in animals and human brain diseases |
| topic | astrocyte axon CNS invertebrate mammal mouse |
| url | https://www.mdpi.com/1422-0067/23/3/1435 |
| work_keys_str_mv | AT hirokoikeshimakataoka integrinsignalinginthecentralnervoussysteminanimalsandhumanbraindiseases AT chikatoshisugimoto integrinsignalinginthecentralnervoussysteminanimalsandhumanbraindiseases AT tatsuyatsubokawa integrinsignalinginthecentralnervoussysteminanimalsandhumanbraindiseases |