Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South India
Background: The histologic pattern causing nephrotic syndrome (NS) and their clinical outcome varies depending on age, sex, race, socioeconomic status and geographic location. There has been a changing trend in the histologic spectrum of NS in the last few decades, in India as well as worldwide. Obj...
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Society of Diabetic Nephropathy Prevention
2017-10-01
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| Series: | Journal of Nephropathology |
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| Online Access: | https://nephropathol.com/PDF/jnp-6-304.pdf |
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| author | Gurudev Konana Vijay Varma Mahesh Eswarappa Sonika Puri Gireesh Mathihally Rakesh Madhyastha Sujeeth Reddy Vijaya Mysorekar Clement Wilfred |
| author_facet | Gurudev Konana Vijay Varma Mahesh Eswarappa Sonika Puri Gireesh Mathihally Rakesh Madhyastha Sujeeth Reddy Vijaya Mysorekar Clement Wilfred |
| author_sort | Gurudev Konana |
| collection | DOAJ |
| description | Background: The histologic pattern causing nephrotic syndrome (NS) and their clinical outcome varies depending on age, sex, race, socioeconomic status and geographic location. There has been a changing trend in the histologic spectrum of NS in the last few decades, in India as well as worldwide. Objectives: The objective of the present study was to see the histologic spectrum of adult NS in our institution and to compare it with data from other centers. Patients and Methods: All adults (≥ 18 years) with nephrotic range proteinuria who underwent renal biopsy from August 2012 to February 2015, were consecutively included in this prospective study. NS caused by diabetes and other secondary glomerular diseases were excluded. Results: Eighty (65.4%) patients were males and 42 (34.4%) were females. The median age at the time of biopsy was 36 years (interquartile range [IQR]: 24.8–45). The most common lesions were minimal change disease (MCD) in 40.2%, membranous nephropathy (MN) in 24.6% and focal segmental glomerulosclerosis (FSGS) in 16.4% of the patients. MCD was observed mostly commonly in the age group 18-35 years and MN was seen mostly commonly in age group 36-55 years. Conclusions: MCD still continues to be leading cause of NS in south Indian adults as evidenced from previous studies from this region. Other common causes include MN and FSGS. The incidence of MPGN is on the decline. |
| first_indexed | 2024-04-09T12:57:36Z |
| format | Article |
| id | doaj.art-e1dd7f4f0f44430188a96b712e470399 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:57:36Z |
| publishDate | 2017-10-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-e1dd7f4f0f44430188a96b712e4703992023-05-13T11:31:11ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192017-10-016430430810.15171/jnp.2017.49jnp-20170615100431Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South IndiaGurudev Konana0Vijay Varma1Mahesh Eswarappa2Sonika Puri3Gireesh Mathihally4Rakesh Madhyastha5Sujeeth Reddy6Vijaya Mysorekar7Clement Wilfred8Department of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of Pathology, M.S. Ramaiah Medical College, Bengaluru, IndiaDepartment of Pathology, M.S. Ramaiah Medical College, Bengaluru, IndiaBackground: The histologic pattern causing nephrotic syndrome (NS) and their clinical outcome varies depending on age, sex, race, socioeconomic status and geographic location. There has been a changing trend in the histologic spectrum of NS in the last few decades, in India as well as worldwide. Objectives: The objective of the present study was to see the histologic spectrum of adult NS in our institution and to compare it with data from other centers. Patients and Methods: All adults (≥ 18 years) with nephrotic range proteinuria who underwent renal biopsy from August 2012 to February 2015, were consecutively included in this prospective study. NS caused by diabetes and other secondary glomerular diseases were excluded. Results: Eighty (65.4%) patients were males and 42 (34.4%) were females. The median age at the time of biopsy was 36 years (interquartile range [IQR]: 24.8–45). The most common lesions were minimal change disease (MCD) in 40.2%, membranous nephropathy (MN) in 24.6% and focal segmental glomerulosclerosis (FSGS) in 16.4% of the patients. MCD was observed mostly commonly in the age group 18-35 years and MN was seen mostly commonly in age group 36-55 years. Conclusions: MCD still continues to be leading cause of NS in south Indian adults as evidenced from previous studies from this region. Other common causes include MN and FSGS. The incidence of MPGN is on the decline.https://nephropathol.com/PDF/jnp-6-304.pdfnephrotic syndromerenalbiopsyminimal change diseasefocal segmental glomerulosclerosisglomerulonephritisiga nephropathy |
| spellingShingle | Gurudev Konana Vijay Varma Mahesh Eswarappa Sonika Puri Gireesh Mathihally Rakesh Madhyastha Sujeeth Reddy Vijaya Mysorekar Clement Wilfred Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South India Journal of Nephropathology nephrotic syndrome renal biopsy minimal change disease focal segmental glomerulosclerosis glomerulonephritis iga nephropathy |
| title | Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South India |
| title_full | Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South India |
| title_fullStr | Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South India |
| title_full_unstemmed | Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South India |
| title_short | Histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics; a single center study from South India |
| title_sort | histologic patterns of primary adult onset nephrotic syndrome and their clinical characteristics a single center study from south india |
| topic | nephrotic syndrome renal biopsy minimal change disease focal segmental glomerulosclerosis glomerulonephritis iga nephropathy |
| url | https://nephropathol.com/PDF/jnp-6-304.pdf |
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