OPSOСLONUS-MYOCLONUS SYNDROME
This article provides an overview of the Russian and foreign studies on paraneoplastic opsoсlonus-myoclonus syndrome. Opsoclonus is characterized by involuntary, arrhythmic, chaotic, multi-directional saccades with horizontal, vertical and torsional components, and it is commonly accompanied by cere...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-02-01
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| Series: | Нервно-мышечные болезни |
| Subjects: | |
| Online Access: | https://nmb.abvpress.ru/jour/article/view/54 |
| _version_ | 1826558121655402496 |
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| author | N. A. Shnayder E. A. Kantimirova V. A. Ezhikova |
| author_facet | N. A. Shnayder E. A. Kantimirova V. A. Ezhikova |
| author_sort | N. A. Shnayder |
| collection | DOAJ |
| description | This article provides an overview of the Russian and foreign studies on paraneoplastic opsoсlonus-myoclonus syndrome. Opsoclonus is characterized by involuntary, arrhythmic, chaotic, multi-directional saccades with horizontal, vertical and torsional components, and it is commonly accompanied by cerebellar ataxia and myoclonic jerks in the trunk and limbs. It is a rare neurological disorder of unknown causes which appears to be the result of an autoimmune process involving the nervous system. Paraneoplastic opsoсlonus-myoclonus syndrome is most commonly associated with small-cell lung cancer, breast cancer, ovarian cancer, non-Hodgkin's lymphoma, renal adenocarcinoma. In children, a neuroblastoma is detected in approximately 50% of cases. Many autoantibodies have been detected in patients with paraneoplastic opsoсlonusmyoclonussyndrome: this finding suggests the involvement of a humoral immune mechanism. However, most patients are seronegative for these autoantibodies. Paraneoplastic opsoсlonus-myoclonus syndrome is less responsive to immunotherapy (corticosteroids, intravenous immunoglobulin, adrenocorticotropic hormone, plasma exchange, cyclophosphamide, or rituximab) and improves only with tumor resection. Further studies are needed to further elucidate its immunopathogenesis and pathophysiology in order to develop novel and efficacious therapy. |
| first_indexed | 2024-03-12T04:45:27Z |
| format | Article |
| id | doaj.art-e1dfb12eeaaa4be9a30a11386a4bbe08 |
| institution | Directory Open Access Journal |
| issn | 2222-8721 2413-0443 |
| language | Russian |
| last_indexed | 2025-03-14T08:39:28Z |
| publishDate | 2015-02-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Нервно-мышечные болезни |
| spelling | doaj.art-e1dfb12eeaaa4be9a30a11386a4bbe082025-03-02T12:54:41ZrusABV-pressНервно-мышечные болезни2222-87212413-04432015-02-0103222610.17650/2222-8721-2013-0-3-22-2648OPSOСLONUS-MYOCLONUS SYNDROMEN. A. Shnayder0E. A. Kantimirova1V. A. Ezhikova2Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation Clinical Hospital Fifty-One, Federal Biomedical Agency, ZheleznogorskProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian FederationProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation A.I. Kryzhanovsky Krasnoyarsk Territorial Cancer CenterThis article provides an overview of the Russian and foreign studies on paraneoplastic opsoсlonus-myoclonus syndrome. Opsoclonus is characterized by involuntary, arrhythmic, chaotic, multi-directional saccades with horizontal, vertical and torsional components, and it is commonly accompanied by cerebellar ataxia and myoclonic jerks in the trunk and limbs. It is a rare neurological disorder of unknown causes which appears to be the result of an autoimmune process involving the nervous system. Paraneoplastic opsoсlonus-myoclonus syndrome is most commonly associated with small-cell lung cancer, breast cancer, ovarian cancer, non-Hodgkin's lymphoma, renal adenocarcinoma. In children, a neuroblastoma is detected in approximately 50% of cases. Many autoantibodies have been detected in patients with paraneoplastic opsoсlonusmyoclonussyndrome: this finding suggests the involvement of a humoral immune mechanism. However, most patients are seronegative for these autoantibodies. Paraneoplastic opsoсlonus-myoclonus syndrome is less responsive to immunotherapy (corticosteroids, intravenous immunoglobulin, adrenocorticotropic hormone, plasma exchange, cyclophosphamide, or rituximab) and improves only with tumor resection. Further studies are needed to further elucidate its immunopathogenesis and pathophysiology in order to develop novel and efficacious therapy.https://nmb.abvpress.ru/jour/article/view/54paraneoplastic neurological syndromeopsoсlonus-myoclonus syndromecancerpathogenesisclinicsdiagnosistreatment |
| spellingShingle | N. A. Shnayder E. A. Kantimirova V. A. Ezhikova OPSOСLONUS-MYOCLONUS SYNDROME Нервно-мышечные болезни paraneoplastic neurological syndrome opsoсlonus-myoclonus syndrome cancer pathogenesis clinics diagnosis treatment |
| title | OPSOСLONUS-MYOCLONUS SYNDROME |
| title_full | OPSOСLONUS-MYOCLONUS SYNDROME |
| title_fullStr | OPSOСLONUS-MYOCLONUS SYNDROME |
| title_full_unstemmed | OPSOСLONUS-MYOCLONUS SYNDROME |
| title_short | OPSOСLONUS-MYOCLONUS SYNDROME |
| title_sort | opsoсlonus myoclonus syndrome |
| topic | paraneoplastic neurological syndrome opsoсlonus-myoclonus syndrome cancer pathogenesis clinics diagnosis treatment |
| url | https://nmb.abvpress.ru/jour/article/view/54 |
| work_keys_str_mv | AT nashnayder opsoslonusmyoclonussyndrome AT eakantimirova opsoslonusmyoclonussyndrome AT vaezhikova opsoslonusmyoclonussyndrome |