Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues
The paraventricular nucleus of the thalamus (PVT) has been implicated in cue-induced motivated behaviors. Although reward-associated cues (conditioned stimuli, CSs) contain different types of information including predictive information of future reward delivery and incentive (motivational) value of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2020.565002/full |
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| author | Unur Munkhzaya Choijiljav Chinzorig Choijiljav Chinzorig Jumpei Matsumoto Jumpei Matsumoto Hiroshi Nishimaru Hiroshi Nishimaru Taketoshi Ono Hisao Nishijo Hisao Nishijo |
| author_facet | Unur Munkhzaya Choijiljav Chinzorig Choijiljav Chinzorig Jumpei Matsumoto Jumpei Matsumoto Hiroshi Nishimaru Hiroshi Nishimaru Taketoshi Ono Hisao Nishijo Hisao Nishijo |
| author_sort | Unur Munkhzaya |
| collection | DOAJ |
| description | The paraventricular nucleus of the thalamus (PVT) has been implicated in cue-induced motivated behaviors. Although reward-associated cues (conditioned stimuli, CSs) contain different types of information including predictive information of future reward delivery and incentive (motivational) value of the reward, it remains unknown whether PVT neurons represent predictive and incentive information of CSs. It is suggested that neural activity just after the onset of CSs (early activity) and that just before reward delivery (late activity) might more strongly represent predictive and incentive information, respectively. In this study, rats were trained to lick a tube, which was protruded close to their mouth just after a CS, to obtain a reward (sucrose or water) (cue-induced licking task). Auditory and visual CSs were used: each elemental cue (CS) predicted reward or non-reward outcome, while simultaneous presentation of the two elemental cues (configural cues) predicted the opposite reward outcome. We recorded PVT neurons in the cue-induced licking task, and report that half of the CS-responsive PVT neurons responded selectively to the CSs predicting reward outcome regardless of physical property of the cues (CS+-selective). In addition, the early activity of the CS+-selective neurons discriminated reward/non-reward association (predictive information) and was less sensitive to reward value and motivation reflected by lick latency (incentive information), while the late activity of the CS+-selective neurons was correlated with reward value and motivation rather than reward/non-reward association. Early and late population activity of the CS+-selective neurons also represented predictive and incentive information of the CSs, respectively. On the other hand, activity of more than half of the PVT neurons was correlated with individual licking during licking to acquire reward. Taken together, the results suggest that the PVT neurons engage in different neural processes involved in cue-induced motivated behaviors: CS encoding to determine reward availability and form motivation for reward-seeking behavior, and hedonic mouth movements during reward consumption. |
| first_indexed | 2024-12-21T01:55:19Z |
| format | Article |
| id | doaj.art-e1e130d2876e4505a07f309e78f9a068 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-21T01:55:19Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-e1e130d2876e4505a07f309e78f9a0682022-12-21T19:19:48ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532020-09-011410.3389/fnbeh.2020.565002565002Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward CuesUnur Munkhzaya0Choijiljav Chinzorig1Choijiljav Chinzorig2Jumpei Matsumoto3Jumpei Matsumoto4Hiroshi Nishimaru5Hiroshi Nishimaru6Taketoshi Ono7Hisao Nishijo8Hisao Nishijo9System Emotional Science, Faculty of Medicine, University of Toyama, Toyama, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama, JapanDepartment of Physiology, School of Bio-Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama, JapanResearch Center for Idling Brain Science (RCIBS), University of Toyama, Toyama, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama, JapanResearch Center for Idling Brain Science (RCIBS), University of Toyama, Toyama, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama, JapanResearch Center for Idling Brain Science (RCIBS), University of Toyama, Toyama, JapanThe paraventricular nucleus of the thalamus (PVT) has been implicated in cue-induced motivated behaviors. Although reward-associated cues (conditioned stimuli, CSs) contain different types of information including predictive information of future reward delivery and incentive (motivational) value of the reward, it remains unknown whether PVT neurons represent predictive and incentive information of CSs. It is suggested that neural activity just after the onset of CSs (early activity) and that just before reward delivery (late activity) might more strongly represent predictive and incentive information, respectively. In this study, rats were trained to lick a tube, which was protruded close to their mouth just after a CS, to obtain a reward (sucrose or water) (cue-induced licking task). Auditory and visual CSs were used: each elemental cue (CS) predicted reward or non-reward outcome, while simultaneous presentation of the two elemental cues (configural cues) predicted the opposite reward outcome. We recorded PVT neurons in the cue-induced licking task, and report that half of the CS-responsive PVT neurons responded selectively to the CSs predicting reward outcome regardless of physical property of the cues (CS+-selective). In addition, the early activity of the CS+-selective neurons discriminated reward/non-reward association (predictive information) and was less sensitive to reward value and motivation reflected by lick latency (incentive information), while the late activity of the CS+-selective neurons was correlated with reward value and motivation rather than reward/non-reward association. Early and late population activity of the CS+-selective neurons also represented predictive and incentive information of the CSs, respectively. On the other hand, activity of more than half of the PVT neurons was correlated with individual licking during licking to acquire reward. Taken together, the results suggest that the PVT neurons engage in different neural processes involved in cue-induced motivated behaviors: CS encoding to determine reward availability and form motivation for reward-seeking behavior, and hedonic mouth movements during reward consumption.https://www.frontiersin.org/article/10.3389/fnbeh.2020.565002/fullparaventricular nucleus of the thalamusconditioned stimulipredictive informationincentive informationseeking behavior |
| spellingShingle | Unur Munkhzaya Choijiljav Chinzorig Choijiljav Chinzorig Jumpei Matsumoto Jumpei Matsumoto Hiroshi Nishimaru Hiroshi Nishimaru Taketoshi Ono Hisao Nishijo Hisao Nishijo Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues Frontiers in Behavioral Neuroscience paraventricular nucleus of the thalamus conditioned stimuli predictive information incentive information seeking behavior |
| title | Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues |
| title_full | Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues |
| title_fullStr | Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues |
| title_full_unstemmed | Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues |
| title_short | Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues |
| title_sort | rat paraventricular neurons encode predictive and incentive information of reward cues |
| topic | paraventricular nucleus of the thalamus conditioned stimuli predictive information incentive information seeking behavior |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2020.565002/full |
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