Chinese Herbal Medicine Improves the Long-Term Survival Rate of Patients With Chronic Kidney Disease in Taiwan: A Nationwide Retrospective Population-Based Cohort Study
Background and purpose: Chinese herbal medicine (CHM) is frequently applied in conjunction with western pharmacotherapy to relieve symptoms in patients with CKD. However, evidence-based research into the effectiveness of CHM use as applied to treat CKD is limited and warrants further investigation....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01117/full |
| _version_ | 1818265504434880512 |
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| author | Kuo-Chin Huang Kuo-Chin Huang Yuan-Chih Su Yuan-Chih Su Yuan-Chih Su Mao-Feng Sun Mao-Feng Sun Sheng-Teng Huang Sheng-Teng Huang Sheng-Teng Huang Sheng-Teng Huang Sheng-Teng Huang |
| author_facet | Kuo-Chin Huang Kuo-Chin Huang Yuan-Chih Su Yuan-Chih Su Yuan-Chih Su Mao-Feng Sun Mao-Feng Sun Sheng-Teng Huang Sheng-Teng Huang Sheng-Teng Huang Sheng-Teng Huang Sheng-Teng Huang |
| author_sort | Kuo-Chin Huang |
| collection | DOAJ |
| description | Background and purpose: Chinese herbal medicine (CHM) is frequently applied in conjunction with western pharmacotherapy to relieve symptoms in patients with CKD. However, evidence-based research into the effectiveness of CHM use as applied to treat CKD is limited and warrants further investigation. The aim of this study is to assess whether adjunctive treatment with CHM affected survival rate of CKD patients undergoing conventional western medical management.Methods: A total of 14,718 CKD patients, including 6,958 CHM users and 7,760 non-CHM users, were recruited from the Longitudinal Health Insurance Database 2000, a sub-dataset of the National Health Insurance Research Database, to conduct this study. Demographic characteristics, including sex, age, job type, residential area, and comorbidity were considered as covariates to adjust the analysis. A network analysis of treatments, including with herbal formulas and single herbs, was performed to investigate the core patterns of CHM use for the treatment of CKD patients. The Kaplan-Meier method was used to determine the survival rate between CHM and non-CHM groups.Results: After matching for sex and age, there were 550 subjects in both the CHM and non-CHM cohorts. Other than presence of diabetes (adjusted OR = 0.57, p < 0.001) and urinary tract infection (adjusted OR = 0.69, p < 0.05), sex, age, job type, area of residence, and other comorbidities indicated no special preference for CHM use among subjects. Salvia miltiorrhiza Bunge (SM) and Ji-Sheng-Shen-Qi-Wan (JSSQW) were the most frequent single herb and formula, respectively, prescribed for patients with CKD. The most frequent CHM combination between herbs and formulas was JSSQW, associated with Rheum officinale Baill. (RO), SM and Astragalus membranaceus (Fisch.) Bunge (AM). The long-term survival rate demonstrated significant benefits for CHM users within a 12-year follow-up period (P < 0.004).Conclusion: This nationwide retrospective cohort study provides valuable insight into the characteristics and prescription patterns of CHM usage in CKD patients. JSSQW associated with RO, SM, and AM is the most common CHM prescription. CHM improves long-term survival in patients with CKD, suggesting that CHM is an effective adjuvant therapy for CKD. |
| first_indexed | 2024-12-12T19:51:51Z |
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| id | doaj.art-e1e143951d8b41ff883c3f2065ed8139 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T19:51:51Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-e1e143951d8b41ff883c3f2065ed81392022-12-22T00:13:58ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-10-01910.3389/fphar.2018.01117353560Chinese Herbal Medicine Improves the Long-Term Survival Rate of Patients With Chronic Kidney Disease in Taiwan: A Nationwide Retrospective Population-Based Cohort StudyKuo-Chin Huang0Kuo-Chin Huang1Yuan-Chih Su2Yuan-Chih Su3Yuan-Chih Su4Mao-Feng Sun5Mao-Feng Sun6Sheng-Teng Huang7Sheng-Teng Huang8Sheng-Teng Huang9Sheng-Teng Huang10Sheng-Teng Huang11Department of Chinese Medicine, China Medical University Hospital, Taichung, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, TaiwanGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung, TaiwanDepartment of Chinese Medicine, China Medical University Hospital, Taichung, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, TaiwanDepartment of Chinese Medicine, China Medical University Hospital, Taichung, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, TaiwanDepartment of Medical Research, Cancer Research Center for Traditional Chinese Medicine, China Medical University Hospital, Taichung, TaiwanChinese Medicine Research Center, China Medical University, Taichung, TaiwanResearch Center for Chinese Herbal Medicine, China Medical University, Taichung, TaiwanBackground and purpose: Chinese herbal medicine (CHM) is frequently applied in conjunction with western pharmacotherapy to relieve symptoms in patients with CKD. However, evidence-based research into the effectiveness of CHM use as applied to treat CKD is limited and warrants further investigation. The aim of this study is to assess whether adjunctive treatment with CHM affected survival rate of CKD patients undergoing conventional western medical management.Methods: A total of 14,718 CKD patients, including 6,958 CHM users and 7,760 non-CHM users, were recruited from the Longitudinal Health Insurance Database 2000, a sub-dataset of the National Health Insurance Research Database, to conduct this study. Demographic characteristics, including sex, age, job type, residential area, and comorbidity were considered as covariates to adjust the analysis. A network analysis of treatments, including with herbal formulas and single herbs, was performed to investigate the core patterns of CHM use for the treatment of CKD patients. The Kaplan-Meier method was used to determine the survival rate between CHM and non-CHM groups.Results: After matching for sex and age, there were 550 subjects in both the CHM and non-CHM cohorts. Other than presence of diabetes (adjusted OR = 0.57, p < 0.001) and urinary tract infection (adjusted OR = 0.69, p < 0.05), sex, age, job type, area of residence, and other comorbidities indicated no special preference for CHM use among subjects. Salvia miltiorrhiza Bunge (SM) and Ji-Sheng-Shen-Qi-Wan (JSSQW) were the most frequent single herb and formula, respectively, prescribed for patients with CKD. The most frequent CHM combination between herbs and formulas was JSSQW, associated with Rheum officinale Baill. (RO), SM and Astragalus membranaceus (Fisch.) Bunge (AM). The long-term survival rate demonstrated significant benefits for CHM users within a 12-year follow-up period (P < 0.004).Conclusion: This nationwide retrospective cohort study provides valuable insight into the characteristics and prescription patterns of CHM usage in CKD patients. JSSQW associated with RO, SM, and AM is the most common CHM prescription. CHM improves long-term survival in patients with CKD, suggesting that CHM is an effective adjuvant therapy for CKD.https://www.frontiersin.org/article/10.3389/fphar.2018.01117/fullchinese herbal medicinechronic kidney diseasesnational health insurance research databaseretrospective cohort studysurvival rate |
| spellingShingle | Kuo-Chin Huang Kuo-Chin Huang Yuan-Chih Su Yuan-Chih Su Yuan-Chih Su Mao-Feng Sun Mao-Feng Sun Sheng-Teng Huang Sheng-Teng Huang Sheng-Teng Huang Sheng-Teng Huang Sheng-Teng Huang Chinese Herbal Medicine Improves the Long-Term Survival Rate of Patients With Chronic Kidney Disease in Taiwan: A Nationwide Retrospective Population-Based Cohort Study Frontiers in Pharmacology chinese herbal medicine chronic kidney diseases national health insurance research database retrospective cohort study survival rate |
| title | Chinese Herbal Medicine Improves the Long-Term Survival Rate of Patients With Chronic Kidney Disease in Taiwan: A Nationwide Retrospective Population-Based Cohort Study |
| title_full | Chinese Herbal Medicine Improves the Long-Term Survival Rate of Patients With Chronic Kidney Disease in Taiwan: A Nationwide Retrospective Population-Based Cohort Study |
| title_fullStr | Chinese Herbal Medicine Improves the Long-Term Survival Rate of Patients With Chronic Kidney Disease in Taiwan: A Nationwide Retrospective Population-Based Cohort Study |
| title_full_unstemmed | Chinese Herbal Medicine Improves the Long-Term Survival Rate of Patients With Chronic Kidney Disease in Taiwan: A Nationwide Retrospective Population-Based Cohort Study |
| title_short | Chinese Herbal Medicine Improves the Long-Term Survival Rate of Patients With Chronic Kidney Disease in Taiwan: A Nationwide Retrospective Population-Based Cohort Study |
| title_sort | chinese herbal medicine improves the long term survival rate of patients with chronic kidney disease in taiwan a nationwide retrospective population based cohort study |
| topic | chinese herbal medicine chronic kidney diseases national health insurance research database retrospective cohort study survival rate |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.01117/full |
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