Aqueous ionic liquids redistribute local enzyme stability via long-range perturbation pathways

Aqueous ionic liquids redistribute local enzyme stability via long-range perturbation pathways

Ionic liquids (IL) and aqueous ionic liquids (aIL) are attractive (co–)solvents for biocatalysis due to their unique properties. On the other hand, the incubation of enzymes in IL or aIL often reduces enzyme activity. Recent studies proposed various aIL-induced effects to explain the reduction, clas...

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Bibliographic Details
Main Authors: Till El Harrar, Benedikt Frieg, Mehdi D. Davari, Karl-Erich Jaeger, Ulrich Schwaneberg, Holger Gohlke
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Protein stability
Molecular dynamics simulations
Allostery
Biocatalysis
Ionic liquids
Protein engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021002919

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