Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma
Objective The current study aimed to investigate the prognosis and treatment of primary cutaneous angiosarcoma (PCA) and primary subcutaneous angiosarcoma (PSCA), and tried to develop a prognostic nomogram model of them. Methods A total of 1763 cases retrieved from the Surveillance, Epidemiology, an...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-07-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2021.1968333 |
| _version_ | 1797683506454724608 |
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| author | Jinqian Mao Jin Hu Yunfei Chen Yiqing Li Xiaoqin Run |
| author_facet | Jinqian Mao Jin Hu Yunfei Chen Yiqing Li Xiaoqin Run |
| author_sort | Jinqian Mao |
| collection | DOAJ |
| description | Objective The current study aimed to investigate the prognosis and treatment of primary cutaneous angiosarcoma (PCA) and primary subcutaneous angiosarcoma (PSCA), and tried to develop a prognostic nomogram model of them. Methods A total of 1763 cases retrieved from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival analyses were performed to explore the prognosis of patients and the effects of different treatment methods. All data were randomly allocated into a training set and a testing set to develop and validate the nomogram model. Results The findings showed that age, sex, grade, tumor size, multiple primary malignant tumors, stage, primary site surgery (PSS), radiotherapy (RT), and chemotherapy (CT) were correlated with prognosis (p < .05). The nomogram achieved good accuracy in predicting the prognosis. PSS + RT + CT showed the best prognosis for patients in stages I, II, and III (p < .05). Conclusion PCA and PSCA are rare with poor prognoses. Patients undergoing PSS may not gain survival benefits from combining with RT or (and) CT, whereas PSS + RT + CT should be actively performed in earlier stages to improve the prognosis of patients. The nomogram model can be used to predict the overall survival rate and guide better treatment. |
| first_indexed | 2024-03-12T00:16:24Z |
| format | Article |
| id | doaj.art-e1e2925777414676a4f8fee10d01435d |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:24Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-e1e2925777414676a4f8fee10d01435d2023-09-15T14:28:51ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-07-013352466247410.1080/09546634.2021.19683331968333Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcomaJinqian Mao0Jin Hu1Yunfei Chen2Yiqing Li3Xiaoqin Run4Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyObjective The current study aimed to investigate the prognosis and treatment of primary cutaneous angiosarcoma (PCA) and primary subcutaneous angiosarcoma (PSCA), and tried to develop a prognostic nomogram model of them. Methods A total of 1763 cases retrieved from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival analyses were performed to explore the prognosis of patients and the effects of different treatment methods. All data were randomly allocated into a training set and a testing set to develop and validate the nomogram model. Results The findings showed that age, sex, grade, tumor size, multiple primary malignant tumors, stage, primary site surgery (PSS), radiotherapy (RT), and chemotherapy (CT) were correlated with prognosis (p < .05). The nomogram achieved good accuracy in predicting the prognosis. PSS + RT + CT showed the best prognosis for patients in stages I, II, and III (p < .05). Conclusion PCA and PSCA are rare with poor prognoses. Patients undergoing PSS may not gain survival benefits from combining with RT or (and) CT, whereas PSS + RT + CT should be actively performed in earlier stages to improve the prognosis of patients. The nomogram model can be used to predict the overall survival rate and guide better treatment.http://dx.doi.org/10.1080/09546634.2021.1968333angiosarcomacutaneous and subcutaneousprognosistreatment |
| spellingShingle | Jinqian Mao Jin Hu Yunfei Chen Yiqing Li Xiaoqin Run Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma Journal of Dermatological Treatment angiosarcoma cutaneous and subcutaneous prognosis treatment |
| title | Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma |
| title_full | Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma |
| title_fullStr | Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma |
| title_full_unstemmed | Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma |
| title_short | Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma |
| title_sort | development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma |
| topic | angiosarcoma cutaneous and subcutaneous prognosis treatment |
| url | http://dx.doi.org/10.1080/09546634.2021.1968333 |
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