Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
It is well known that mitochondrial damage is both the major contributor to oxidative stress (the condition arising from unbalance between production and removal of reactive oxygen species) and one of the major consequences of oxidative stress, because of the high dependence of mitochondrial functio...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2015-02-01
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Series: | Frontiers in Cellular Neuroscience |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00041/full |
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author | Maria Teresa eCarri Maria Teresa eCarri Cristiana eValle Cristiana eValle Francesca eBozzo Francesca eBozzo Mauro eCozzolino |
author_facet | Maria Teresa eCarri Maria Teresa eCarri Cristiana eValle Cristiana eValle Francesca eBozzo Francesca eBozzo Mauro eCozzolino |
author_sort | Maria Teresa eCarri |
collection | DOAJ |
description | It is well known that mitochondrial damage is both the major contributor to oxidative stress (the condition arising from unbalance between production and removal of reactive oxygen species) and one of the major consequences of oxidative stress, because of the high dependence of mitochondrial function on redox-sensitive targets such as intact membranes.Conditions in which neuronal cells are not able to cope with mitochondrial damage and oxidative stress seem to lead or contribute to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS), at least in the most studied SOD1-linked genetic variant.As summarized in this review, new evidence indicates that mitochondrial damage and oxidative stress play a role also in non-SOD1 ALS and thus they may represent a target for therapy despite previous failures in clinical trials. |
first_indexed | 2024-04-13T07:26:13Z |
format | Article |
id | doaj.art-e1e2a872a8f74a83bef292faf8f2b597 |
institution | Directory Open Access Journal |
issn | 1662-5102 |
language | English |
last_indexed | 2024-04-13T07:26:13Z |
publishDate | 2015-02-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Cellular Neuroscience |
spelling | doaj.art-e1e2a872a8f74a83bef292faf8f2b5972022-12-22T02:56:28ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-02-01910.3389/fncel.2015.00041132313Oxidative stress and mitochondrial damage: importance in non-SOD1 ALSMaria Teresa eCarri0Maria Teresa eCarri1Cristiana eValle2Cristiana eValle3Francesca eBozzo4Francesca eBozzo5Mauro eCozzolino6Fondazione Santa Lucia, IRCCSUniversità di Roma Tor VergataNational Research Council, CNRFondazione Santa Lucia, IRCCSFondazione Santa Lucia, IRCCSUniversità di Roma Tor VergataInstitute of Translational Pharmacology, National Research CouncilIt is well known that mitochondrial damage is both the major contributor to oxidative stress (the condition arising from unbalance between production and removal of reactive oxygen species) and one of the major consequences of oxidative stress, because of the high dependence of mitochondrial function on redox-sensitive targets such as intact membranes.Conditions in which neuronal cells are not able to cope with mitochondrial damage and oxidative stress seem to lead or contribute to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS), at least in the most studied SOD1-linked genetic variant.As summarized in this review, new evidence indicates that mitochondrial damage and oxidative stress play a role also in non-SOD1 ALS and thus they may represent a target for therapy despite previous failures in clinical trials.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00041/fullAmyotrophic Lateral SclerosisMitochondriaOxidative StressneurodegenerationALS |
spellingShingle | Maria Teresa eCarri Maria Teresa eCarri Cristiana eValle Cristiana eValle Francesca eBozzo Francesca eBozzo Mauro eCozzolino Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS Frontiers in Cellular Neuroscience Amyotrophic Lateral Sclerosis Mitochondria Oxidative Stress neurodegeneration ALS |
title | Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS |
title_full | Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS |
title_fullStr | Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS |
title_full_unstemmed | Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS |
title_short | Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS |
title_sort | oxidative stress and mitochondrial damage importance in non sod1 als |
topic | Amyotrophic Lateral Sclerosis Mitochondria Oxidative Stress neurodegeneration ALS |
url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00041/full |
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