Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS

It is well known that mitochondrial damage is both the major contributor to oxidative stress (the condition arising from unbalance between production and removal of reactive oxygen species) and one of the major consequences of oxidative stress, because of the high dependence of mitochondrial functio...

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Main Authors: Maria Teresa eCarri, Cristiana eValle, Francesca eBozzo, Mauro eCozzolino
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00041/full
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author Maria Teresa eCarri
Maria Teresa eCarri
Cristiana eValle
Cristiana eValle
Francesca eBozzo
Francesca eBozzo
Mauro eCozzolino
author_facet Maria Teresa eCarri
Maria Teresa eCarri
Cristiana eValle
Cristiana eValle
Francesca eBozzo
Francesca eBozzo
Mauro eCozzolino
author_sort Maria Teresa eCarri
collection DOAJ
description It is well known that mitochondrial damage is both the major contributor to oxidative stress (the condition arising from unbalance between production and removal of reactive oxygen species) and one of the major consequences of oxidative stress, because of the high dependence of mitochondrial function on redox-sensitive targets such as intact membranes.Conditions in which neuronal cells are not able to cope with mitochondrial damage and oxidative stress seem to lead or contribute to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS), at least in the most studied SOD1-linked genetic variant.As summarized in this review, new evidence indicates that mitochondrial damage and oxidative stress play a role also in non-SOD1 ALS and thus they may represent a target for therapy despite previous failures in clinical trials.
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spelling doaj.art-e1e2a872a8f74a83bef292faf8f2b5972022-12-22T02:56:28ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-02-01910.3389/fncel.2015.00041132313Oxidative stress and mitochondrial damage: importance in non-SOD1 ALSMaria Teresa eCarri0Maria Teresa eCarri1Cristiana eValle2Cristiana eValle3Francesca eBozzo4Francesca eBozzo5Mauro eCozzolino6Fondazione Santa Lucia, IRCCSUniversità di Roma Tor VergataNational Research Council, CNRFondazione Santa Lucia, IRCCSFondazione Santa Lucia, IRCCSUniversità di Roma Tor VergataInstitute of Translational Pharmacology, National Research CouncilIt is well known that mitochondrial damage is both the major contributor to oxidative stress (the condition arising from unbalance between production and removal of reactive oxygen species) and one of the major consequences of oxidative stress, because of the high dependence of mitochondrial function on redox-sensitive targets such as intact membranes.Conditions in which neuronal cells are not able to cope with mitochondrial damage and oxidative stress seem to lead or contribute to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS), at least in the most studied SOD1-linked genetic variant.As summarized in this review, new evidence indicates that mitochondrial damage and oxidative stress play a role also in non-SOD1 ALS and thus they may represent a target for therapy despite previous failures in clinical trials.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00041/fullAmyotrophic Lateral SclerosisMitochondriaOxidative StressneurodegenerationALS
spellingShingle Maria Teresa eCarri
Maria Teresa eCarri
Cristiana eValle
Cristiana eValle
Francesca eBozzo
Francesca eBozzo
Mauro eCozzolino
Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
Frontiers in Cellular Neuroscience
Amyotrophic Lateral Sclerosis
Mitochondria
Oxidative Stress
neurodegeneration
ALS
title Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
title_full Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
title_fullStr Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
title_full_unstemmed Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
title_short Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
title_sort oxidative stress and mitochondrial damage importance in non sod1 als
topic Amyotrophic Lateral Sclerosis
Mitochondria
Oxidative Stress
neurodegeneration
ALS
url http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00041/full
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