Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort study
Abstract Background Previous studies have suggested that oil-based contrast agents used during hysterosalpingography (HSG) in infertile patients can enhance fertility. However, limited research has investigated the effect of oil-based contrast medium specifically in individuals with endometriosis-re...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12958-024-01190-1 |
| _version_ | 1797272790022225920 |
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| author | Baoli Xie Yingqin Huang Fu Hang Jiaxin Yu Qianwen Hu Jiaxu Li Aiping Qin |
| author_facet | Baoli Xie Yingqin Huang Fu Hang Jiaxin Yu Qianwen Hu Jiaxu Li Aiping Qin |
| author_sort | Baoli Xie |
| collection | DOAJ |
| description | Abstract Background Previous studies have suggested that oil-based contrast agents used during hysterosalpingography (HSG) in infertile patients can enhance fertility. However, limited research has investigated the effect of oil-based contrast medium specifically in individuals with endometriosis-related infertility. Objective This study aims to explore the impact of oil-based contrast medium on fertility outcomes in women with endometriosis-related infertility. Methods Conducted at the First Affiliated Hospital of Guangxi Medical University (January 2020 to June 2022), the study included 512 patients undergoing HSG. Patients were categorized into oil-based and non-oil-based groups, and after propensity score matching, demographic characteristics were compared. Main outcomes included clinical pregnancy rates, live birth rates, early miscarriage rates, and ectopic pregnancy rates. Results In our analysis, the Oil-based group showed significantly better outcomes compared to the Non-oil-based group. Specifically, the Oil-based group had higher clinical pregnancy rates (51.39% vs. 27.36%) and increased live birth rates (31.48% vs. 19.93%). This trend held true for expectant treatment, IUI, and IVF/ICSI, except for surgical treatment where no significant difference was observed. After adjusting for various factors using propensity score matching, the Non-oil-based group consistently exhibited lower clinical pregnancy rates compared to the Oil-based group. The Odds Ratio (OR) was 0.38 (95%CI: 0.27–0.55) without adjustment, 0.34 (0.22–0.51) in multivariable analysis, 0.39 (0.27–0.57) using inverse probability of treatment weighting (IPTW), and 0.22 (0.14–0.35) in propensity score matching. Conclusion Oil-based contrast medium used in HSG for women with endometriosis-related infertility is associated with higher clinical pregnancy rates and live birth rates compared to Non-oil-based contrast medium. |
| first_indexed | 2024-03-07T14:34:24Z |
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| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-03-07T14:34:24Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-e1e321b428174642bf3006ccecd6bea12024-03-05T20:44:08ZengBMCReproductive Biology and Endocrinology1477-78272024-02-012211910.1186/s12958-024-01190-1Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort studyBaoli Xie0Yingqin Huang1Fu Hang2Jiaxin Yu3Qianwen Hu4Jiaxu Li5Aiping Qin6Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical UniversityCenter for Reproductive Medicine, Maternal and Child Health Hospital in GuangxiCenter of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical UniversityCenter of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical UniversityCenter of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical UniversityCenter of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical UniversityCenter of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical UniversityAbstract Background Previous studies have suggested that oil-based contrast agents used during hysterosalpingography (HSG) in infertile patients can enhance fertility. However, limited research has investigated the effect of oil-based contrast medium specifically in individuals with endometriosis-related infertility. Objective This study aims to explore the impact of oil-based contrast medium on fertility outcomes in women with endometriosis-related infertility. Methods Conducted at the First Affiliated Hospital of Guangxi Medical University (January 2020 to June 2022), the study included 512 patients undergoing HSG. Patients were categorized into oil-based and non-oil-based groups, and after propensity score matching, demographic characteristics were compared. Main outcomes included clinical pregnancy rates, live birth rates, early miscarriage rates, and ectopic pregnancy rates. Results In our analysis, the Oil-based group showed significantly better outcomes compared to the Non-oil-based group. Specifically, the Oil-based group had higher clinical pregnancy rates (51.39% vs. 27.36%) and increased live birth rates (31.48% vs. 19.93%). This trend held true for expectant treatment, IUI, and IVF/ICSI, except for surgical treatment where no significant difference was observed. After adjusting for various factors using propensity score matching, the Non-oil-based group consistently exhibited lower clinical pregnancy rates compared to the Oil-based group. The Odds Ratio (OR) was 0.38 (95%CI: 0.27–0.55) without adjustment, 0.34 (0.22–0.51) in multivariable analysis, 0.39 (0.27–0.57) using inverse probability of treatment weighting (IPTW), and 0.22 (0.14–0.35) in propensity score matching. Conclusion Oil-based contrast medium used in HSG for women with endometriosis-related infertility is associated with higher clinical pregnancy rates and live birth rates compared to Non-oil-based contrast medium.https://doi.org/10.1186/s12958-024-01190-1HSGOil-based contrast mediumFertility enhancementInfertilityEndometriosisPropensity score matching(PSM) |
| spellingShingle | Baoli Xie Yingqin Huang Fu Hang Jiaxin Yu Qianwen Hu Jiaxu Li Aiping Qin Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort study Reproductive Biology and Endocrinology HSG Oil-based contrast medium Fertility enhancement Infertility Endometriosis Propensity score matching(PSM) |
| title | Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort study |
| title_full | Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort study |
| title_fullStr | Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort study |
| title_full_unstemmed | Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort study |
| title_short | Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort study |
| title_sort | impact of oil based contrast agents in hysterosalpingography on fertility outcomes in endometriosis a retrospective cohort study |
| topic | HSG Oil-based contrast medium Fertility enhancement Infertility Endometriosis Propensity score matching(PSM) |
| url | https://doi.org/10.1186/s12958-024-01190-1 |
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