A theory of loop formation and elimination by spike timing-dependent plasticity
We show that the local Spike Timing-Dependent Plasticity (STDP) rule has the effect of regulating the trans-synaptic weights of loops of any length within a simulated network of neurons. We show that depending on STDP's polarity, functional loops are formed or eliminated in networks driven to n...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-03-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2010.00007/full |
| _version_ | 1818519151279341568 |
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| author | James Kozloski Guillermo A Cecchi |
| author_facet | James Kozloski Guillermo A Cecchi |
| author_sort | James Kozloski |
| collection | DOAJ |
| description | We show that the local Spike Timing-Dependent Plasticity (STDP) rule has the effect of regulating the trans-synaptic weights of loops of any length within a simulated network of neurons. We show that depending on STDP's polarity, functional loops are formed or eliminated in networks driven to normal spiking conditions by random, partially correlated inputs, where functional loops comprise synaptic weights that exceed a non-zero threshold. We further prove that STDP is a form of loop-regulating plasticity for the case of a linear network driven by noise. Thus a notable local synaptic learning rule makes a specific prediction about synapses in the brain in which standard STDP is present: that under normal spiking conditions, they should participate in predominantly feed-forward connections at all scales. Our model implies that any deviations from this prediction would require a substantial modification to the hypothesized role for standard STDP. Given its widespread occurrence in the brain, we predict that STDP could also regulate long range functional loops among individual neurons across all brain scales, up to, and including, the scale of global brain network topology. |
| first_indexed | 2024-12-11T01:20:11Z |
| format | Article |
| id | doaj.art-e1e3e13ffd8a4e5b8058497c3c3114ee |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-11T01:20:11Z |
| publishDate | 2010-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-e1e3e13ffd8a4e5b8058497c3c3114ee2022-12-22T01:25:45ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102010-03-01410.3389/fncir.2010.00007727A theory of loop formation and elimination by spike timing-dependent plasticityJames Kozloski0Guillermo A Cecchi1IBM T.J. Watson Research CenterIBM T.J. Watson Research CenterWe show that the local Spike Timing-Dependent Plasticity (STDP) rule has the effect of regulating the trans-synaptic weights of loops of any length within a simulated network of neurons. We show that depending on STDP's polarity, functional loops are formed or eliminated in networks driven to normal spiking conditions by random, partially correlated inputs, where functional loops comprise synaptic weights that exceed a non-zero threshold. We further prove that STDP is a form of loop-regulating plasticity for the case of a linear network driven by noise. Thus a notable local synaptic learning rule makes a specific prediction about synapses in the brain in which standard STDP is present: that under normal spiking conditions, they should participate in predominantly feed-forward connections at all scales. Our model implies that any deviations from this prediction would require a substantial modification to the hypothesized role for standard STDP. Given its widespread occurrence in the brain, we predict that STDP could also regulate long range functional loops among individual neurons across all brain scales, up to, and including, the scale of global brain network topology.http://journal.frontiersin.org/Journal/10.3389/fncir.2010.00007/fullNeocortexSTDPNeuromodulationtopologymicrocircuitrydorsal striatum |
| spellingShingle | James Kozloski Guillermo A Cecchi A theory of loop formation and elimination by spike timing-dependent plasticity Frontiers in Neural Circuits Neocortex STDP Neuromodulation topology microcircuitry dorsal striatum |
| title | A theory of loop formation and elimination by spike timing-dependent plasticity |
| title_full | A theory of loop formation and elimination by spike timing-dependent plasticity |
| title_fullStr | A theory of loop formation and elimination by spike timing-dependent plasticity |
| title_full_unstemmed | A theory of loop formation and elimination by spike timing-dependent plasticity |
| title_short | A theory of loop formation and elimination by spike timing-dependent plasticity |
| title_sort | theory of loop formation and elimination by spike timing dependent plasticity |
| topic | Neocortex STDP Neuromodulation topology microcircuitry dorsal striatum |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2010.00007/full |
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