Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European Population
This study analyzed the correlations between the acute and habitual intake of dietary tyrosols, their main food sources, and 24 h urine excretions of tyrosol (Tyr) and hydroxytyrosol (OHTyr) in participants from the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participa...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/3/715 |
| _version_ | 1827751646344511488 |
|---|---|
| author | Enrique Almanza-Aguilera Estefanía Davila-Cordova Daniel Guiñón-Fort Marta Farràs Giovanna Masala Maria Santucci de Magistris Ivan Baldassari Rosario Tumino Lisa Padroni Verena A Katzke Matthias B. Schulze Augustin Scalbert Raul Zamora-Ros |
| author_facet | Enrique Almanza-Aguilera Estefanía Davila-Cordova Daniel Guiñón-Fort Marta Farràs Giovanna Masala Maria Santucci de Magistris Ivan Baldassari Rosario Tumino Lisa Padroni Verena A Katzke Matthias B. Schulze Augustin Scalbert Raul Zamora-Ros |
| author_sort | Enrique Almanza-Aguilera |
| collection | DOAJ |
| description | This study analyzed the correlations between the acute and habitual intake of dietary tyrosols, their main food sources, and 24 h urine excretions of tyrosol (Tyr) and hydroxytyrosol (OHTyr) in participants from the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (n = 419) were healthy men and women aged from 34 to 73 years from 8 EPIC centers belonging to France, Italy, and Germany. Acute and habitual dietary data were collected using a standardized 24 h dietary recall software and validated country-specific dietary questionnaires, respectively. The intake of 13 dietary tyrosols was estimated using the Phenol-Explorer database. Excretions of Tyr and OHTyr in a single 24 h urine sample were analyzed using tandem mass spectrometry. Urinary excretions of Tyr, OHTyr, and their sum (Tyr + OHTyr) correlated more strongly with their corresponding acute (rho<sub>partial</sub>~0.63) rather than habitual intakes (rho<sub>partial</sub>~0.47). In addition, individual and combined urinary excretions of Tyr and OHTyr were weakly to moderately correlated with the acute and habitual intake of other individual tyrosol precursors (rho<sub>partial</sub> = 0.10–0.44) and especially with major food sources, such as wine (rho<sub>partial</sub> = 0.41–0.58), olive oil (rho<sub>partial</sub> = 0.25–0.44), and beer (rho<sub>partial</sub> = 0.14–0.23). Urinary Tyr + OHTyr excretions were similarly correlated with the acute intake of total tyrosols but differently correlated with food sources among countries. Based on these results, we conclude that 24 h urinary excretions of Tyr + OHTyr could be proposed as biomarkers of total tyrosol intake, preferably for acute intakes. |
| first_indexed | 2024-03-11T07:01:00Z |
| format | Article |
| id | doaj.art-e1e4a5e5d00247a0a83b25b500ba02e1 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T07:01:00Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e1e4a5e5d00247a0a83b25b500ba02e12023-11-17T09:18:45ZengMDPI AGAntioxidants2076-39212023-03-0112371510.3390/antiox12030715Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European PopulationEnrique Almanza-Aguilera0Estefanía Davila-Cordova1Daniel Guiñón-Fort2Marta Farràs3Giovanna Masala4Maria Santucci de Magistris5Ivan Baldassari6Rosario Tumino7Lisa Padroni8Verena A Katzke9Matthias B. Schulze10Augustin Scalbert11Raul Zamora-Ros12Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, SpainUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, SpainUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, SpainUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, SpainCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), 50139 Florence, ItalyDipartimento di Medicina Clinica e Chirurgia, Federico II, 80131 Naples, ItalyDepartment of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, ItalyCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), 97100 Ragusa, ItalyUnit of Cancer Epidemiology, Città della Salute e della Scienza University, Hospital and Center for Cancer Prevention (CPO), Via Santena 7, 10126 Turin, ItalyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, GermanyNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, FranceUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, SpainThis study analyzed the correlations between the acute and habitual intake of dietary tyrosols, their main food sources, and 24 h urine excretions of tyrosol (Tyr) and hydroxytyrosol (OHTyr) in participants from the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (n = 419) were healthy men and women aged from 34 to 73 years from 8 EPIC centers belonging to France, Italy, and Germany. Acute and habitual dietary data were collected using a standardized 24 h dietary recall software and validated country-specific dietary questionnaires, respectively. The intake of 13 dietary tyrosols was estimated using the Phenol-Explorer database. Excretions of Tyr and OHTyr in a single 24 h urine sample were analyzed using tandem mass spectrometry. Urinary excretions of Tyr, OHTyr, and their sum (Tyr + OHTyr) correlated more strongly with their corresponding acute (rho<sub>partial</sub>~0.63) rather than habitual intakes (rho<sub>partial</sub>~0.47). In addition, individual and combined urinary excretions of Tyr and OHTyr were weakly to moderately correlated with the acute and habitual intake of other individual tyrosol precursors (rho<sub>partial</sub> = 0.10–0.44) and especially with major food sources, such as wine (rho<sub>partial</sub> = 0.41–0.58), olive oil (rho<sub>partial</sub> = 0.25–0.44), and beer (rho<sub>partial</sub> = 0.14–0.23). Urinary Tyr + OHTyr excretions were similarly correlated with the acute intake of total tyrosols but differently correlated with food sources among countries. Based on these results, we conclude that 24 h urinary excretions of Tyr + OHTyr could be proposed as biomarkers of total tyrosol intake, preferably for acute intakes.https://www.mdpi.com/2076-3921/12/3/715tyrosolhydroxytyrosolurineolive oilwinebiomarkers |
| spellingShingle | Enrique Almanza-Aguilera Estefanía Davila-Cordova Daniel Guiñón-Fort Marta Farràs Giovanna Masala Maria Santucci de Magistris Ivan Baldassari Rosario Tumino Lisa Padroni Verena A Katzke Matthias B. Schulze Augustin Scalbert Raul Zamora-Ros Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European Population Antioxidants tyrosol hydroxytyrosol urine olive oil wine biomarkers |
| title | Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European Population |
| title_full | Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European Population |
| title_fullStr | Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European Population |
| title_full_unstemmed | Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European Population |
| title_short | Correlation Analysis between Dietary Intake of Tyrosols and Their Food Sources and Urinary Excretion of Tyrosol and Hydroxytyrosol in a European Population |
| title_sort | correlation analysis between dietary intake of tyrosols and their food sources and urinary excretion of tyrosol and hydroxytyrosol in a european population |
| topic | tyrosol hydroxytyrosol urine olive oil wine biomarkers |
| url | https://www.mdpi.com/2076-3921/12/3/715 |
| work_keys_str_mv | AT enriquealmanzaaguilera correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT estefaniadavilacordova correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT danielguinonfort correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT martafarras correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT giovannamasala correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT mariasantuccidemagistris correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT ivanbaldassari correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT rosariotumino correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT lisapadroni correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT verenaakatzke correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT matthiasbschulze correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT augustinscalbert correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation AT raulzamoraros correlationanalysisbetweendietaryintakeoftyrosolsandtheirfoodsourcesandurinaryexcretionoftyrosolandhydroxytyrosolinaeuropeanpopulation |