Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia
Oxygen is compulsory for mitochondrial function and energy supply, but it has numerous more nuanced roles. The different roles of oxygen in peripheral nerve regeneration range from energy supply, inflammation, phagocytosis, and oxidative cell destruction in the context of reperfusion injury to cruci...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/4/2030 |
| _version_ | 1797298044372254720 |
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| author | Dominik André-Lévigne Rodrigue Pignel Sylvain Boet Vincent Jaquet Daniel F. Kalbermatten Srinivas Madduri |
| author_facet | Dominik André-Lévigne Rodrigue Pignel Sylvain Boet Vincent Jaquet Daniel F. Kalbermatten Srinivas Madduri |
| author_sort | Dominik André-Lévigne |
| collection | DOAJ |
| description | Oxygen is compulsory for mitochondrial function and energy supply, but it has numerous more nuanced roles. The different roles of oxygen in peripheral nerve regeneration range from energy supply, inflammation, phagocytosis, and oxidative cell destruction in the context of reperfusion injury to crucial redox signaling cascades that are necessary for effective axonal outgrowth. A fine balance between reactive oxygen species production and antioxidant activity draws the line between physiological and pathological nerve regeneration. There is compelling evidence that redox signaling mediated by the Nox family of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases plays an important role in peripheral nerve regeneration. Further research is needed to better characterize the role of Nox in physiological and pathological circumstances, but the available data suggest that the modulation of Nox activity fosters great therapeutic potential. One of the promising approaches to enhance nerve regeneration by modulating the redox environment is hyperbaric oxygen therapy. In this review, we highlight the influence of various oxygenation states, i.e., hypoxia, physoxia, and hyperoxia, on peripheral nerve repair and regeneration. We summarize the currently available data and knowledge on the effectiveness of using hyperbaric oxygen therapy to treat nerve injuries and discuss future directions. |
| first_indexed | 2024-03-07T22:30:08Z |
| format | Article |
| id | doaj.art-e1e53365301a4481bee056dd0dba0a81 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-07T22:30:08Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e1e53365301a4481bee056dd0dba0a812024-02-23T15:19:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01254203010.3390/ijms25042030Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to HyperoxiaDominik André-Lévigne0Rodrigue Pignel1Sylvain Boet2Vincent Jaquet3Daniel F. Kalbermatten4Srinivas Madduri5Division of Plastic, Reconstructive and Aesthetic Surgery, Geneva University Hospitals, 1205 Geneva, SwitzerlandSubaquatic and Hyperbaric Medicine Unit, Division of Emergency Medicine, Department of Anesthesiology, Clinical Pharmacology, Intensive Care and Emergency Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandSubaquatic and Hyperbaric Medicine Unit, Division of Emergency Medicine, Department of Anesthesiology, Clinical Pharmacology, Intensive Care and Emergency Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandDepartment of Cell Physiology and Metabolism, University of Geneva, 1205 Geneva, SwitzerlandDivision of Plastic, Reconstructive and Aesthetic Surgery, Geneva University Hospitals, 1205 Geneva, SwitzerlandDivision of Plastic, Reconstructive and Aesthetic Surgery, Geneva University Hospitals, 1205 Geneva, SwitzerlandOxygen is compulsory for mitochondrial function and energy supply, but it has numerous more nuanced roles. The different roles of oxygen in peripheral nerve regeneration range from energy supply, inflammation, phagocytosis, and oxidative cell destruction in the context of reperfusion injury to crucial redox signaling cascades that are necessary for effective axonal outgrowth. A fine balance between reactive oxygen species production and antioxidant activity draws the line between physiological and pathological nerve regeneration. There is compelling evidence that redox signaling mediated by the Nox family of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases plays an important role in peripheral nerve regeneration. Further research is needed to better characterize the role of Nox in physiological and pathological circumstances, but the available data suggest that the modulation of Nox activity fosters great therapeutic potential. One of the promising approaches to enhance nerve regeneration by modulating the redox environment is hyperbaric oxygen therapy. In this review, we highlight the influence of various oxygenation states, i.e., hypoxia, physoxia, and hyperoxia, on peripheral nerve repair and regeneration. We summarize the currently available data and knowledge on the effectiveness of using hyperbaric oxygen therapy to treat nerve injuries and discuss future directions.https://www.mdpi.com/1422-0067/25/4/2030nerve repairnerve regenerationaxonal growthsensory functionmotor function |
| spellingShingle | Dominik André-Lévigne Rodrigue Pignel Sylvain Boet Vincent Jaquet Daniel F. Kalbermatten Srinivas Madduri Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia International Journal of Molecular Sciences nerve repair nerve regeneration axonal growth sensory function motor function |
| title | Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia |
| title_full | Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia |
| title_fullStr | Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia |
| title_full_unstemmed | Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia |
| title_short | Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia |
| title_sort | role of oxygen and its radicals in peripheral nerve regeneration from hypoxia to physoxia to hyperoxia |
| topic | nerve repair nerve regeneration axonal growth sensory function motor function |
| url | https://www.mdpi.com/1422-0067/25/4/2030 |
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