Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity

Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity

Here, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPαR35A) that greatly accelerates BMT helped to illuminate the mechanism. Thus, incoming C/EBPα binds to...

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Bibliographic Details
Main Authors: Guillem Torcal Garcia, Elisabeth Kowenz-Leutz, Tian V Tian, Antonis Klonizakis, Jonathan Lerner, Luisa De Andres-Aguayo, Valeriia Sapozhnikova, Clara Berenguer, Marcos Plana Carmona, Maria Vila Casadesus, Romain Bulteau, Mirko Francesconi, Sandra Peiro, Philipp Mertins, Kenneth Zaret, Achim Leutz, Thomas Graf
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
cell fate
transcription factor
gene regulation
blood cell differentiation
lineage choice
transdifferentiation
Online Access:https://elifesciences.org/articles/83951

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