Genetic ancestry and diagnostic yield of exome sequencing in a diverse population

Genetic ancestry and diagnostic yield of exome sequencing in a diverse population

Abstract It has been suggested that diagnostic yield (DY) from Exome Sequencing (ES) may be lower among patients with non-European ancestries than those with European ancestry. We examined the association of DY with estimated continental/subcontinental genetic ancestry in a racially/ethnically diver...

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Main Authors: Yusuph Mavura, Nuriye Sahin-Hodoglugil, Ugur Hodoglugil, Mark Kvale, Pierre-Marie Martin, Jessica Van Ziffle, W. Patrick Devine, Sara L. Ackerman, Barbara A. Koenig, Pui-Yan Kwok, Mary E. Norton, Anne Slavotinek, Neil Risch
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-023-00385-6

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https://doi.org/10.1038/s41525-023-00385-6

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