From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics
This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of apt...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/21/3/724 |
| _version_ | 1797408636073410560 |
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| author | Robert Ziółkowski Marta Jarczewska Łukasz Górski Elżbieta Malinowska |
| author_facet | Robert Ziółkowski Marta Jarczewska Łukasz Górski Elżbieta Malinowska |
| author_sort | Robert Ziółkowski |
| collection | DOAJ |
| description | This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs, neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses. We described also possible future perspectives of aptasensors development. This concerns (i) the approaches to lowering the detection limit and improvement of the electrochemical aptasensors selectivity by application of the hybrid aptamer–antibody receptor layers and/or nanomaterials; and (ii) electrochemical aptasensors integration with more advanced microfluidic devices as user-friendly medical instruments for medical diagnostic of the future. |
| first_indexed | 2024-03-09T04:01:57Z |
| format | Article |
| id | doaj.art-e1eaf7853eab4145a18d2710c18127c6 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-09T04:01:57Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-e1eaf7853eab4145a18d2710c18127c62023-12-03T14:12:32ZengMDPI AGSensors1424-82202021-01-0121372410.3390/s21030724From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical DiagnosticsRobert Ziółkowski0Marta Jarczewska1Łukasz Górski2Elżbieta Malinowska3Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandThis paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs, neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses. We described also possible future perspectives of aptasensors development. This concerns (i) the approaches to lowering the detection limit and improvement of the electrochemical aptasensors selectivity by application of the hybrid aptamer–antibody receptor layers and/or nanomaterials; and (ii) electrochemical aptasensors integration with more advanced microfluidic devices as user-friendly medical instruments for medical diagnostic of the future.https://www.mdpi.com/1424-8220/21/3/724aptasensorselectrochemistrymedical diagnosticsSELEXmetal cationscancer biomarkers |
| spellingShingle | Robert Ziółkowski Marta Jarczewska Łukasz Górski Elżbieta Malinowska From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics Sensors aptasensors electrochemistry medical diagnostics SELEX metal cations cancer biomarkers |
| title | From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics |
| title_full | From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics |
| title_fullStr | From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics |
| title_full_unstemmed | From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics |
| title_short | From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics |
| title_sort | from small molecules toward whole cells detection application of electrochemical aptasensors in modern medical diagnostics |
| topic | aptasensors electrochemistry medical diagnostics SELEX metal cations cancer biomarkers |
| url | https://www.mdpi.com/1424-8220/21/3/724 |
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