Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases
Immune surveillance and adaptive immune responses, involving continuously circulating and tissue-resident T-lymphocytes, provide host defense against infectious agents and possible malignant transformation while avoiding autoimmune tissue damage. Activation, migration, and deployment of T-cells to a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/21/2541 |
| _version_ | 1797632101599674368 |
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| author | Irene Rose Antony Brandon Han Siang Wong Dermot Kelleher Navin Kumar Verma |
| author_facet | Irene Rose Antony Brandon Han Siang Wong Dermot Kelleher Navin Kumar Verma |
| author_sort | Irene Rose Antony |
| collection | DOAJ |
| description | Immune surveillance and adaptive immune responses, involving continuously circulating and tissue-resident T-lymphocytes, provide host defense against infectious agents and possible malignant transformation while avoiding autoimmune tissue damage. Activation, migration, and deployment of T-cells to affected tissue sites are crucial for mounting an adaptive immune response. An effective adaptive immune defense depends on the ability of T-cells to dynamically reprogram their metabolic requirements in response to environmental cues. Inability of the T-cells to adapt to specific metabolic demands may skew cells to become either hyporesponsive (creating immunocompromised conditions) or hyperactive (causing autoimmune tissue destruction). Here, we review maladaptive T-cell metabolic fitness that can cause autoimmune diseases and discuss how T-cell metabolic programs can potentially be modulated to achieve therapeutic benefits. |
| first_indexed | 2024-03-11T11:33:04Z |
| format | Article |
| id | doaj.art-e1ebfde8c1c547ac9881e4834f2ae37d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T11:33:04Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e1ebfde8c1c547ac9881e4834f2ae37d2023-11-10T15:00:42ZengMDPI AGCells2073-44092023-10-011221254110.3390/cells12212541Maladaptive T-Cell Metabolic Fitness in Autoimmune DiseasesIrene Rose Antony0Brandon Han Siang Wong1Dermot Kelleher2Navin Kumar Verma3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeImmune surveillance and adaptive immune responses, involving continuously circulating and tissue-resident T-lymphocytes, provide host defense against infectious agents and possible malignant transformation while avoiding autoimmune tissue damage. Activation, migration, and deployment of T-cells to affected tissue sites are crucial for mounting an adaptive immune response. An effective adaptive immune defense depends on the ability of T-cells to dynamically reprogram their metabolic requirements in response to environmental cues. Inability of the T-cells to adapt to specific metabolic demands may skew cells to become either hyporesponsive (creating immunocompromised conditions) or hyperactive (causing autoimmune tissue destruction). Here, we review maladaptive T-cell metabolic fitness that can cause autoimmune diseases and discuss how T-cell metabolic programs can potentially be modulated to achieve therapeutic benefits.https://www.mdpi.com/2073-4409/12/21/2541autoimmunityglycolysisLFA-1metabolitespsoriasisrheumatoid arthritis |
| spellingShingle | Irene Rose Antony Brandon Han Siang Wong Dermot Kelleher Navin Kumar Verma Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases Cells autoimmunity glycolysis LFA-1 metabolites psoriasis rheumatoid arthritis |
| title | Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases |
| title_full | Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases |
| title_fullStr | Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases |
| title_full_unstemmed | Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases |
| title_short | Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases |
| title_sort | maladaptive t cell metabolic fitness in autoimmune diseases |
| topic | autoimmunity glycolysis LFA-1 metabolites psoriasis rheumatoid arthritis |
| url | https://www.mdpi.com/2073-4409/12/21/2541 |
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