Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility
Neuronal migration is a critical process in the development of the nervous system. Defects in the migration of the neurons are associated with diseases like lissencephaly, subcortical band heterotopia (SBH), and pachygyria. Doublecortin (DCX) is an essential factor in neurogenesis and mutations in t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00199/full |
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| author | Abiola A. Ayanlaja Ye Xiong Yue Gao GuangQuan Ji Chuanxi Tang Zamzam Abdikani Abdullah DianShuai Gao |
| author_facet | Abiola A. Ayanlaja Ye Xiong Yue Gao GuangQuan Ji Chuanxi Tang Zamzam Abdikani Abdullah DianShuai Gao |
| author_sort | Abiola A. Ayanlaja |
| collection | DOAJ |
| description | Neuronal migration is a critical process in the development of the nervous system. Defects in the migration of the neurons are associated with diseases like lissencephaly, subcortical band heterotopia (SBH), and pachygyria. Doublecortin (DCX) is an essential factor in neurogenesis and mutations in this protein impairs neuronal migration leading to several pathological conditions. Although, DCX is capable of modulating and stabilizing microtubules (MTs) to ensure effective migration, the mechanisms involved in executing these functions remain poorly understood. Meanwhile, there are existing gaps regarding the processes that underlie tumor initiation and progression into cancer as well as the ability to migrate and invade normal cells. Several studies suggest that DCX is involved in cancer metastasis. Unstable interactions between DCX and MTs destabilizes cytoskeletal organization leading to disorganized movements of cells, a process which may be implicated in the uncontrolled migration of cancer cells. However, the underlying mechanism is complex and require further clarification. Therefore, exploring the importance and features known up to date about this molecule will broaden our understanding and shed light on potential therapeutic approaches for the associated neurological diseases. This review summarizes current knowledge about DCX, its features, functions, and relationships with other proteins. We also present an overview of its role in cancer cells and highlight the importance of studying its gene mutations. |
| first_indexed | 2024-12-23T11:31:58Z |
| format | Article |
| id | doaj.art-e1ec189389dc469484d2ef59349256ca |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-23T11:31:58Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-e1ec189389dc469484d2ef59349256ca2022-12-21T17:48:47ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992017-06-011010.3389/fnmol.2017.00199270229Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell MobilityAbiola A. AyanlajaYe XiongYue GaoGuangQuan JiChuanxi TangZamzam Abdikani AbdullahDianShuai GaoNeuronal migration is a critical process in the development of the nervous system. Defects in the migration of the neurons are associated with diseases like lissencephaly, subcortical band heterotopia (SBH), and pachygyria. Doublecortin (DCX) is an essential factor in neurogenesis and mutations in this protein impairs neuronal migration leading to several pathological conditions. Although, DCX is capable of modulating and stabilizing microtubules (MTs) to ensure effective migration, the mechanisms involved in executing these functions remain poorly understood. Meanwhile, there are existing gaps regarding the processes that underlie tumor initiation and progression into cancer as well as the ability to migrate and invade normal cells. Several studies suggest that DCX is involved in cancer metastasis. Unstable interactions between DCX and MTs destabilizes cytoskeletal organization leading to disorganized movements of cells, a process which may be implicated in the uncontrolled migration of cancer cells. However, the underlying mechanism is complex and require further clarification. Therefore, exploring the importance and features known up to date about this molecule will broaden our understanding and shed light on potential therapeutic approaches for the associated neurological diseases. This review summarizes current knowledge about DCX, its features, functions, and relationships with other proteins. We also present an overview of its role in cancer cells and highlight the importance of studying its gene mutations.http://journal.frontiersin.org/article/10.3389/fnmol.2017.00199/fullDCX-doublecortinMT-microtubuleNSC-neural stem cellsCSC-cancer stem cellsGBM-glioblastoma multiformeMAP-microtubule-associated protein |
| spellingShingle | Abiola A. Ayanlaja Ye Xiong Yue Gao GuangQuan Ji Chuanxi Tang Zamzam Abdikani Abdullah DianShuai Gao Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility Frontiers in Molecular Neuroscience DCX-doublecortin MT-microtubule NSC-neural stem cells CSC-cancer stem cells GBM-glioblastoma multiforme MAP-microtubule-associated protein |
| title | Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility |
| title_full | Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility |
| title_fullStr | Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility |
| title_full_unstemmed | Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility |
| title_short | Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility |
| title_sort | distinct features of doublecortin as a marker of neuronal migration and its implications in cancer cell mobility |
| topic | DCX-doublecortin MT-microtubule NSC-neural stem cells CSC-cancer stem cells GBM-glioblastoma multiforme MAP-microtubule-associated protein |
| url | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00199/full |
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