Insulin-Like Growth Factor-1 as a Possible Alternative to Bone Morphogenetic Protein-7 to Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells in Vitro

Insulin-Like Growth Factor-1 as a Possible Alternative to Bone Morphogenetic Protein-7 to Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells in Vitro

Growth factors and mesenchymal stem cells (MSC) support consolidation of bone defects. Bone Morphogenetic Protein-7 (BMP-7) has been used clinically and experimentally, but the outcomes remain controversial. Increased systemic expression of Insulin-like Growth Factor-1 (IGF-1) significantly correlat...

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Bibliographic Details
Main Authors: Bruno Reible, Gerhard Schmidmaier, Arash Moghaddam, Fabian Westhauser
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
human mesenchymal stem cells (MSC)
Insulin-like Growth Factor-1 (IGF-1)
Bone Morphogenetic Protein-7 (BMP-7)
osteogenic differentiation
in vitro
Online Access:http://www.mdpi.com/1422-0067/19/6/1674

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