Oral adverse events following COVID-19 and influenza vaccination in Australia
Vaccine hesitancy, spurred by misinterpretation of Adverse Events (AEs), threatens public health. Despite sporadic reports of oral AEs post-COVID-19 vaccination, systematic analysis is scarce. This study evaluates these AEs using the Australian Database of Adverse Event Notifications (DAEN). A secon...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-08-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2023.2253589 |
| _version_ | 1797633750126821376 |
|---|---|
| author | Abanoub Riad Julien Issa Sameh Attia Ladislav Dušek Miloslav Klugar |
| author_facet | Abanoub Riad Julien Issa Sameh Attia Ladislav Dušek Miloslav Klugar |
| author_sort | Abanoub Riad |
| collection | DOAJ |
| description | Vaccine hesitancy, spurred by misinterpretation of Adverse Events (AEs), threatens public health. Despite sporadic reports of oral AEs post-COVID-19 vaccination, systematic analysis is scarce. This study evaluates these AEs using the Australian Database of Adverse Event Notifications (DAEN). A secondary analysis of DAEN data was conducted, with the analysis period commencing from the start of the COVID-19 vaccination rollout in February 2021 and the inception of the influenza vaccine database in 1971, both through until December 2022. The focus of the analysis was on oral AEs related to COVID-19 and influenza vaccines. Reports were extracted according to a predefined schema and then stratified by vaccine type, sex, and age. Oral paresthesia was the most common oral AE after COVID-19 vaccination (75.28 per 10,000 reports), followed by dysgeusia (73.96), swollen tongue (51.55), lip swelling (49.43), taste disorder (27.32), ageusia (25.85), dry mouth (24.75), mouth ulceration (18.97), oral hypoaesthesia (15.60), and oral herpes (12.74). While COVID-19 and influenza vaccines shared most oral AEs, taste-related AEs, dry mouth, and oral herpes were significantly more common after COVID-19 vaccination. mRNA vaccines yielded more oral AEs than other types. Females had higher oral AE incidence. Most oral AEs did not differ significantly between COVID-19 and influenza vaccination. However, specific oral AEs, particularly taste-related, dry mouth, and oral herpes, were more prevalent after COVID-19 vaccination compared with seasonal influenza, especially in females and mRNA vaccine recipients. |
| first_indexed | 2024-03-11T11:58:14Z |
| format | Article |
| id | doaj.art-e1ed41467a8e42df9342e2d7fe00359b |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T11:58:14Z |
| publishDate | 2023-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-e1ed41467a8e42df9342e2d7fe00359b2023-11-08T11:55:20ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-08-0119210.1080/21645515.2023.22535892253589Oral adverse events following COVID-19 and influenza vaccination in AustraliaAbanoub Riad0Julien Issa1Sameh Attia2Ladislav Dušek3Miloslav Klugar4Institute of Health Information and Statistics of the Czech Republic (IHIS-CR)University of Medical SciencesJustus-Liebig-UniversityInstitute of Health Information and Statistics of the Czech Republic (IHIS-CR)Institute of Health Information and Statistics of the Czech Republic (IHIS-CR)Vaccine hesitancy, spurred by misinterpretation of Adverse Events (AEs), threatens public health. Despite sporadic reports of oral AEs post-COVID-19 vaccination, systematic analysis is scarce. This study evaluates these AEs using the Australian Database of Adverse Event Notifications (DAEN). A secondary analysis of DAEN data was conducted, with the analysis period commencing from the start of the COVID-19 vaccination rollout in February 2021 and the inception of the influenza vaccine database in 1971, both through until December 2022. The focus of the analysis was on oral AEs related to COVID-19 and influenza vaccines. Reports were extracted according to a predefined schema and then stratified by vaccine type, sex, and age. Oral paresthesia was the most common oral AE after COVID-19 vaccination (75.28 per 10,000 reports), followed by dysgeusia (73.96), swollen tongue (51.55), lip swelling (49.43), taste disorder (27.32), ageusia (25.85), dry mouth (24.75), mouth ulceration (18.97), oral hypoaesthesia (15.60), and oral herpes (12.74). While COVID-19 and influenza vaccines shared most oral AEs, taste-related AEs, dry mouth, and oral herpes were significantly more common after COVID-19 vaccination. mRNA vaccines yielded more oral AEs than other types. Females had higher oral AE incidence. Most oral AEs did not differ significantly between COVID-19 and influenza vaccination. However, specific oral AEs, particularly taste-related, dry mouth, and oral herpes, were more prevalent after COVID-19 vaccination compared with seasonal influenza, especially in females and mRNA vaccine recipients.http://dx.doi.org/10.1080/21645515.2023.2253589covid-19 vaccinesdrug-related side effects and adverse reactionsherpes zosterpharmacovigilancetaste disorders |
| spellingShingle | Abanoub Riad Julien Issa Sameh Attia Ladislav Dušek Miloslav Klugar Oral adverse events following COVID-19 and influenza vaccination in Australia Human Vaccines & Immunotherapeutics covid-19 vaccines drug-related side effects and adverse reactions herpes zoster pharmacovigilance taste disorders |
| title | Oral adverse events following COVID-19 and influenza vaccination in Australia |
| title_full | Oral adverse events following COVID-19 and influenza vaccination in Australia |
| title_fullStr | Oral adverse events following COVID-19 and influenza vaccination in Australia |
| title_full_unstemmed | Oral adverse events following COVID-19 and influenza vaccination in Australia |
| title_short | Oral adverse events following COVID-19 and influenza vaccination in Australia |
| title_sort | oral adverse events following covid 19 and influenza vaccination in australia |
| topic | covid-19 vaccines drug-related side effects and adverse reactions herpes zoster pharmacovigilance taste disorders |
| url | http://dx.doi.org/10.1080/21645515.2023.2253589 |
| work_keys_str_mv | AT abanoubriad oraladverseeventsfollowingcovid19andinfluenzavaccinationinaustralia AT julienissa oraladverseeventsfollowingcovid19andinfluenzavaccinationinaustralia AT samehattia oraladverseeventsfollowingcovid19andinfluenzavaccinationinaustralia AT ladislavdusek oraladverseeventsfollowingcovid19andinfluenzavaccinationinaustralia AT miloslavklugar oraladverseeventsfollowingcovid19andinfluenzavaccinationinaustralia |