Solifenacin versus posterior tibial nerve stimulation for overactive bladder in patients with multiple sclerosis
IntroductionOveractive bladder (OAB) is one of the most common complications in patients with multiple sclerosis (MS). Choosing the effective treatment is very important in improving their quality of life (QOL). Therefore, the aim of this study was to compare solifenacin (SS) and posterior tibial ne...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1107886/full |
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| author | Nastaran Majdinasab Neda Orakifar Neda Orakifar Leila Kouti Gholamreza Shamsaei Maryam Seyedtabib Mohammad Jafari |
| author_facet | Nastaran Majdinasab Neda Orakifar Neda Orakifar Leila Kouti Gholamreza Shamsaei Maryam Seyedtabib Mohammad Jafari |
| author_sort | Nastaran Majdinasab |
| collection | DOAJ |
| description | IntroductionOveractive bladder (OAB) is one of the most common complications in patients with multiple sclerosis (MS). Choosing the effective treatment is very important in improving their quality of life (QOL). Therefore, the aim of this study was to compare solifenacin (SS) and posterior tibial nerve stimulation (PTNS) treatment effects in the MS Patients with OAB.Materials and methodsIn total, 70 MS patients suffering from OAB enrolled in this clinical trial study. Patients with a score of at least 3 according to the OAB questionnaire were randomly divided into two groups (35 patients in each group). In one group, patients received SS (5 mg daily for 4 weeks and 10 mg/day for another 8 weeks) and in a second group, patients were treated by PTNS (12 weekly session, 30 min).ResultsThe mean (SD) age of patients participating in this study was 39.82 (9.088) and 42.41 (9.175) years for the SS group and the PTNS group, respectively. Patients in both groups showed statistically significant improvements in urinary incontinence, micturition, and daytime frequency (p < 0.001). Patients in the SS group had a better response for urinary incontinence after 12 weeks compared to the PTNS group. Also, patients in the SS group reported higher satisfaction and less daytime frequency compared to the PTNS group.ConclusionSS and PTNS were effective for improving the OAB symptoms in patients with MS. However, patients demonstrated a better experience with SS in terms of daytime frequency, urinary incontinence, and treatment satisfaction rate. |
| first_indexed | 2024-04-10T09:07:09Z |
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| id | doaj.art-e1ee391a2a29473a9824e7f4fb91bf72 |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-10T09:07:09Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-e1ee391a2a29473a9824e7f4fb91bf722023-02-21T06:35:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-02-011710.3389/fnins.2023.11078861107886Solifenacin versus posterior tibial nerve stimulation for overactive bladder in patients with multiple sclerosisNastaran Majdinasab0Neda Orakifar1Neda Orakifar2Leila Kouti3Gholamreza Shamsaei4Maryam Seyedtabib5Mohammad Jafari6Member of Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Physiotherapy, School of Rehabilitation Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranMusculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranFaculty of Pharmacy, Clinical Pharmacy Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Neurology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Neurology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranIntroductionOveractive bladder (OAB) is one of the most common complications in patients with multiple sclerosis (MS). Choosing the effective treatment is very important in improving their quality of life (QOL). Therefore, the aim of this study was to compare solifenacin (SS) and posterior tibial nerve stimulation (PTNS) treatment effects in the MS Patients with OAB.Materials and methodsIn total, 70 MS patients suffering from OAB enrolled in this clinical trial study. Patients with a score of at least 3 according to the OAB questionnaire were randomly divided into two groups (35 patients in each group). In one group, patients received SS (5 mg daily for 4 weeks and 10 mg/day for another 8 weeks) and in a second group, patients were treated by PTNS (12 weekly session, 30 min).ResultsThe mean (SD) age of patients participating in this study was 39.82 (9.088) and 42.41 (9.175) years for the SS group and the PTNS group, respectively. Patients in both groups showed statistically significant improvements in urinary incontinence, micturition, and daytime frequency (p < 0.001). Patients in the SS group had a better response for urinary incontinence after 12 weeks compared to the PTNS group. Also, patients in the SS group reported higher satisfaction and less daytime frequency compared to the PTNS group.ConclusionSS and PTNS were effective for improving the OAB symptoms in patients with MS. However, patients demonstrated a better experience with SS in terms of daytime frequency, urinary incontinence, and treatment satisfaction rate.https://www.frontiersin.org/articles/10.3389/fnins.2023.1107886/fullmultiple sclerosisoveractive bladderquality of lifeelectrical nerve stimulationsolifenacin |
| spellingShingle | Nastaran Majdinasab Neda Orakifar Neda Orakifar Leila Kouti Gholamreza Shamsaei Maryam Seyedtabib Mohammad Jafari Solifenacin versus posterior tibial nerve stimulation for overactive bladder in patients with multiple sclerosis Frontiers in Neuroscience multiple sclerosis overactive bladder quality of life electrical nerve stimulation solifenacin |
| title | Solifenacin versus posterior tibial nerve stimulation for overactive bladder in patients with multiple sclerosis |
| title_full | Solifenacin versus posterior tibial nerve stimulation for overactive bladder in patients with multiple sclerosis |
| title_fullStr | Solifenacin versus posterior tibial nerve stimulation for overactive bladder in patients with multiple sclerosis |
| title_full_unstemmed | Solifenacin versus posterior tibial nerve stimulation for overactive bladder in patients with multiple sclerosis |
| title_short | Solifenacin versus posterior tibial nerve stimulation for overactive bladder in patients with multiple sclerosis |
| title_sort | solifenacin versus posterior tibial nerve stimulation for overactive bladder in patients with multiple sclerosis |
| topic | multiple sclerosis overactive bladder quality of life electrical nerve stimulation solifenacin |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1107886/full |
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