Effects of Prevotella copri on insulin, gut microbiota and bile acids
ABSTRACTObesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the underlying mechanism remains unclear. In this study, a significant positive correlation was obs...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2340487 |
| _version_ | 1827280265612886016 |
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| author | Jiatai Gong Qianjin Zhang Ruizhi Hu Xizi Yang Chengkun Fang Liping Yao Jing Lv Long Wang Mingkun Shi Wentao Zhang Siqi Ma Hongkun Xiang Hongfu Zhang De-Xing Hou Yulong Yin Jianhua He Lijun Peng Shusong Wu |
| author_facet | Jiatai Gong Qianjin Zhang Ruizhi Hu Xizi Yang Chengkun Fang Liping Yao Jing Lv Long Wang Mingkun Shi Wentao Zhang Siqi Ma Hongkun Xiang Hongfu Zhang De-Xing Hou Yulong Yin Jianhua He Lijun Peng Shusong Wu |
| author_sort | Jiatai Gong |
| collection | DOAJ |
| description | ABSTRACTObesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the underlying mechanism remains unclear. In this study, a significant positive correlation was observed between Prevotella copri (P. copri) and obesity in children (p = 0.003). Next, the effect of P. copri on obesity was explored by using fecal microbiota transplantation (FMT) experiment. Transplantation of P. copri. increased serum levels of fasting blood glucose (p < 0.01), insulin (p < 0.01) and interleukin-1β (IL-1β) (p < 0.05) in high-fat diet (HFD)-induced obese mice, but not in normal mice. Characterization of the gut microbiota indicated that P. copri reduced the relative abundance of the Akkermansia genus in mice (p < 0.01). Further analysis on bile acids (BAs) revealed that P. copri increased the primary BAs and ursodeoxycholic acid (UDCA) in HFD-induced mice (p < 0.05). This study demonstrated for the first time that P. copri has a significant positive correlation with obesity in children, and can increase fasting blood glucose and insulin levels in HFD-fed obese mice, which are related to the abundance of Akkermansia genus and bile acids. |
| first_indexed | 2024-04-24T08:33:59Z |
| format | Article |
| id | doaj.art-e1eec2907dba4e6f8252c13348cae9c3 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T08:33:59Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-e1eec2907dba4e6f8252c13348cae9c32024-04-16T18:19:26ZengTaylor & Francis GroupGut Microbes1949-09761949-09842024-12-0116110.1080/19490976.2024.2340487Effects of Prevotella copri on insulin, gut microbiota and bile acidsJiatai Gong0Qianjin Zhang1Ruizhi Hu2Xizi Yang3Chengkun Fang4Liping Yao5Jing Lv6Long Wang7Mingkun Shi8Wentao Zhang9Siqi Ma10Hongkun Xiang11Hongfu Zhang12De-Xing Hou13Yulong Yin14Jianhua He15Lijun Peng16Shusong Wu17Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaChildren’s Healthcare Institute, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaABSTRACTObesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the underlying mechanism remains unclear. In this study, a significant positive correlation was observed between Prevotella copri (P. copri) and obesity in children (p = 0.003). Next, the effect of P. copri on obesity was explored by using fecal microbiota transplantation (FMT) experiment. Transplantation of P. copri. increased serum levels of fasting blood glucose (p < 0.01), insulin (p < 0.01) and interleukin-1β (IL-1β) (p < 0.05) in high-fat diet (HFD)-induced obese mice, but not in normal mice. Characterization of the gut microbiota indicated that P. copri reduced the relative abundance of the Akkermansia genus in mice (p < 0.01). Further analysis on bile acids (BAs) revealed that P. copri increased the primary BAs and ursodeoxycholic acid (UDCA) in HFD-induced mice (p < 0.05). This study demonstrated for the first time that P. copri has a significant positive correlation with obesity in children, and can increase fasting blood glucose and insulin levels in HFD-fed obese mice, which are related to the abundance of Akkermansia genus and bile acids.https://www.tandfonline.com/doi/10.1080/19490976.2024.2340487Obesityprevotella copriinsulingut microbiotabile acids |
| spellingShingle | Jiatai Gong Qianjin Zhang Ruizhi Hu Xizi Yang Chengkun Fang Liping Yao Jing Lv Long Wang Mingkun Shi Wentao Zhang Siqi Ma Hongkun Xiang Hongfu Zhang De-Xing Hou Yulong Yin Jianhua He Lijun Peng Shusong Wu Effects of Prevotella copri on insulin, gut microbiota and bile acids Gut Microbes Obesity prevotella copri insulin gut microbiota bile acids |
| title | Effects of Prevotella copri on insulin, gut microbiota and bile acids |
| title_full | Effects of Prevotella copri on insulin, gut microbiota and bile acids |
| title_fullStr | Effects of Prevotella copri on insulin, gut microbiota and bile acids |
| title_full_unstemmed | Effects of Prevotella copri on insulin, gut microbiota and bile acids |
| title_short | Effects of Prevotella copri on insulin, gut microbiota and bile acids |
| title_sort | effects of prevotella copri on insulin gut microbiota and bile acids |
| topic | Obesity prevotella copri insulin gut microbiota bile acids |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2340487 |
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