Distinct behavioral consequences of short-term and prolonged GABAergic depletion in prefrontal cortex and dorsal hippocampus

Distinct behavioral consequences of short-term and prolonged GABAergic depletion in prefrontal cortex and dorsal hippocampus

GABAergic interneurons are essential for a functional equilibrium between excitatory and inhibitory impulses throughout the CNS. Disruption of this equilibrium can lead to various neurological or neuropsychiatric disorders such as epileptic seizures or schizophrenia. Schizophrenia itself is clinical...

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Bibliographic Details
Main Authors: Judith M. Reichel, Sabine eNissel, Gabriela eRogel-Salazar, Anna eMederer, Karola eKäfer, Benedikt T. Bedenk, Henrik eMartens, Rebecca eAnders, Jens eGrosche, Dominik eMichalski, Wolfgang eHärtig, Carsten T. Wotjak
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Hippocampus
Prefrontal Cortex
Schizophrenia
GABA
spatial memory
Spatial learning
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00452/full

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