PROGNOSTIC AND DIAGNOSTIC SIGNIFICANCE OF THE CLARA CELL PROTEIN LEVEL IN BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS
Background. Bronchopulmonary dysplasia (BPD) is a polyetiological chronic disease of morphologically immature lungs that develops in premature newborns receiving oxygen and undergoing mechanical lung ventilation (MLV). The study of the severity and outcomes of bronchopulmonary dysplasia is one of th...
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| Format: | Article |
| Language: | Belarusian |
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Grodno State Medical University
2020-06-01
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| Series: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| Subjects: | |
| Online Access: | http://journal-grsmu.by/index.php/ojs/article/view/2566 |
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| author | Zhuravleva L. N. Novikova V. I. |
| author_facet | Zhuravleva L. N. Novikova V. I. |
| author_sort | Zhuravleva L. N. |
| collection | DOAJ |
| description | Background. Bronchopulmonary dysplasia (BPD) is a polyetiological chronic disease of morphologically immature lungs that develops in premature newborns receiving oxygen and undergoing mechanical lung ventilation (MLV). The study of the severity and outcomes of bronchopulmonary dysplasia is one of the signifcant felds of modern research studies in pediatrics.
The aim of our research was to determine Clara cell protein (CCP) levels in tracheal aspirate and blood serum in mechanically ventilated premature newborns with features of respiratory failure, who were subsequently diagnosed with BPD.
Material and methods. Under our supervision, there were 34 preterm infants with respiratory disorders, who
have been on mechanical ventilation for more than 1 week. The object of the study was serum and tracheal aspirate, sampling was performed twice on the 1st-2nd days and on the 10th-12th days.
Results. In children who developed BPD, a low level of CCP in tracheal aspirate was noted. The level of CCP
positively correlated with the diagnosis of BPD and negatively with the severity of the disease.
Conclusions. Children with bronchopulmonary dysplasia on the 1st-2nd and 10th-12th days of life in TA and blood serum showed a low concentration of CCP (p <0.01) compared with the group of children without BPD. |
| first_indexed | 2024-12-18T05:22:01Z |
| format | Article |
| id | doaj.art-e1ef230cd9d544efb75e59224eaf4c68 |
| institution | Directory Open Access Journal |
| issn | 2221-8785 2413-0109 |
| language | Belarusian |
| last_indexed | 2024-12-18T05:22:01Z |
| publishDate | 2020-06-01 |
| publisher | Grodno State Medical University |
| record_format | Article |
| series | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| spelling | doaj.art-e1ef230cd9d544efb75e59224eaf4c682022-12-21T21:19:38ZbelGrodno State Medical UniversityŽurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta2221-87852413-01092020-06-0118330430810.25298/2221-8785-2020-18-3-304-308PROGNOSTIC AND DIAGNOSTIC SIGNIFICANCE OF THE CLARA CELL PROTEIN LEVEL IN BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNSZhuravleva L. N.0Novikova V. I.1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, BelarusVitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, BelarusBackground. Bronchopulmonary dysplasia (BPD) is a polyetiological chronic disease of morphologically immature lungs that develops in premature newborns receiving oxygen and undergoing mechanical lung ventilation (MLV). The study of the severity and outcomes of bronchopulmonary dysplasia is one of the signifcant felds of modern research studies in pediatrics. The aim of our research was to determine Clara cell protein (CCP) levels in tracheal aspirate and blood serum in mechanically ventilated premature newborns with features of respiratory failure, who were subsequently diagnosed with BPD. Material and methods. Under our supervision, there were 34 preterm infants with respiratory disorders, who have been on mechanical ventilation for more than 1 week. The object of the study was serum and tracheal aspirate, sampling was performed twice on the 1st-2nd days and on the 10th-12th days. Results. In children who developed BPD, a low level of CCP in tracheal aspirate was noted. The level of CCP positively correlated with the diagnosis of BPD and negatively with the severity of the disease. Conclusions. Children with bronchopulmonary dysplasia on the 1st-2nd and 10th-12th days of life in TA and blood serum showed a low concentration of CCP (p <0.01) compared with the group of children without BPD.http://journal-grsmu.by/index.php/ojs/article/view/2566newbornsbronchopulmonary dysplasiaclara cell proteinbiomarkerspremature newborns |
| spellingShingle | Zhuravleva L. N. Novikova V. I. PROGNOSTIC AND DIAGNOSTIC SIGNIFICANCE OF THE CLARA CELL PROTEIN LEVEL IN BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta newborns bronchopulmonary dysplasia clara cell protein biomarkers premature newborns |
| title | PROGNOSTIC AND DIAGNOSTIC SIGNIFICANCE OF THE CLARA CELL PROTEIN LEVEL IN BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS |
| title_full | PROGNOSTIC AND DIAGNOSTIC SIGNIFICANCE OF THE CLARA CELL PROTEIN LEVEL IN BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS |
| title_fullStr | PROGNOSTIC AND DIAGNOSTIC SIGNIFICANCE OF THE CLARA CELL PROTEIN LEVEL IN BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS |
| title_full_unstemmed | PROGNOSTIC AND DIAGNOSTIC SIGNIFICANCE OF THE CLARA CELL PROTEIN LEVEL IN BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS |
| title_short | PROGNOSTIC AND DIAGNOSTIC SIGNIFICANCE OF THE CLARA CELL PROTEIN LEVEL IN BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS |
| title_sort | prognostic and diagnostic significance of the clara cell protein level in bronchopulmonary dysplasia in preterm newborns |
| topic | newborns bronchopulmonary dysplasia clara cell protein biomarkers premature newborns |
| url | http://journal-grsmu.by/index.php/ojs/article/view/2566 |
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