Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardia...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.788955/full |
| _version_ | 1818424569808027648 |
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| author | Jeremy Kah Sheng Pang Jeremy Kah Sheng Pang Beatrice Xuan Ho Beatrice Xuan Ho Woon-Khiong Chan Boon-Seng Soh Boon-Seng Soh |
| author_facet | Jeremy Kah Sheng Pang Jeremy Kah Sheng Pang Beatrice Xuan Ho Beatrice Xuan Ho Woon-Khiong Chan Boon-Seng Soh Boon-Seng Soh |
| author_sort | Jeremy Kah Sheng Pang |
| collection | DOAJ |
| description | Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardiac organoid cultures have shown their utility in modelling key developmental hallmarks of heart organogenesis, but the complexity of the organ demands a more versatile model that can investigate more fundamental parameters, such as structure, organization and compartmentalization of a functioning heart. This review will cover the prominence of cardiac organoids in recent research, unpack current in vitro 3D models of the developing heart and look into the prospect of developing physiologically appropriate cardiac organoids with translational applicability. In addition, we discuss some of the limitations of existing cardiac organoid models in modelling embryonic development of the heart and manifestation of cardiac diseases. |
| first_indexed | 2024-12-14T14:00:08Z |
| format | Article |
| id | doaj.art-e1efb5545d6b48ccb3b29587391405fb |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-14T14:00:08Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e1efb5545d6b48ccb3b29587391405fb2022-12-21T22:58:44ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-12-01910.3389/fcell.2021.788955788955Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D OrganoidsJeremy Kah Sheng Pang0Jeremy Kah Sheng Pang1Beatrice Xuan Ho2Beatrice Xuan Ho3Woon-Khiong Chan4Boon-Seng Soh5Boon-Seng Soh6Disease Modeling and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, SingaporeDepartment of Biological Sciences, National University of Singapore, Singapore, SingaporeDisease Modeling and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, SingaporeDepartment of Biological Sciences, National University of Singapore, Singapore, SingaporeDepartment of Biological Sciences, National University of Singapore, Singapore, SingaporeDisease Modeling and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, SingaporeDepartment of Biological Sciences, National University of Singapore, Singapore, SingaporeMedical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardiac organoid cultures have shown their utility in modelling key developmental hallmarks of heart organogenesis, but the complexity of the organ demands a more versatile model that can investigate more fundamental parameters, such as structure, organization and compartmentalization of a functioning heart. This review will cover the prominence of cardiac organoids in recent research, unpack current in vitro 3D models of the developing heart and look into the prospect of developing physiologically appropriate cardiac organoids with translational applicability. In addition, we discuss some of the limitations of existing cardiac organoid models in modelling embryonic development of the heart and manifestation of cardiac diseases.https://www.frontiersin.org/articles/10.3389/fcell.2021.788955/fullstem cellembryonic developmentorganoid systemscardiovascular disease modellingdrug screeningbiomaterials |
| spellingShingle | Jeremy Kah Sheng Pang Jeremy Kah Sheng Pang Beatrice Xuan Ho Beatrice Xuan Ho Woon-Khiong Chan Boon-Seng Soh Boon-Seng Soh Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids Frontiers in Cell and Developmental Biology stem cell embryonic development organoid systems cardiovascular disease modelling drug screening biomaterials |
| title | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
| title_full | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
| title_fullStr | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
| title_full_unstemmed | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
| title_short | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
| title_sort | insights to heart development and cardiac disease models using pluripotent stem cell derived 3d organoids |
| topic | stem cell embryonic development organoid systems cardiovascular disease modelling drug screening biomaterials |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.788955/full |
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