Immunomodulatory role of metalloproteases in cancers: Current progress and future trends
Metalloproteinases (MPs) is a large family of proteinases with metal ions in their active centers. According to the different domains metalloproteinases can be divided into a variety of subtypes mainly including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteases (ADAMs) and ADAMs w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1064033/full |
| _version_ | 1797980777667887104 |
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| author | Qi Wang Kai Wang Xiaojing Tan Zhenxiang Li Haiyong Wang |
| author_facet | Qi Wang Kai Wang Xiaojing Tan Zhenxiang Li Haiyong Wang |
| author_sort | Qi Wang |
| collection | DOAJ |
| description | Metalloproteinases (MPs) is a large family of proteinases with metal ions in their active centers. According to the different domains metalloproteinases can be divided into a variety of subtypes mainly including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteases (ADAMs) and ADAMs with Thrombospondin Motifs (ADAMTS). They have various functions such as protein hydrolysis, cell adhesion and remodeling of extracellular matrix. Metalloproteinases expressed in multiple types of cancers and participate in many pathological processes involving tumor genesis and development, invasion and metastasis by regulating signal transduction and tumor microenvironment. In this review, based on the current research progress, we summarized the structure of MPs, their expression and especially immunomodulatory role and mechanisms in cancers. Additionally, a relevant and timely update of recent advances and future directions were provided for the diagnosis and immunotherapy targeting MPs in cancers. |
| first_indexed | 2024-04-11T05:59:10Z |
| format | Article |
| id | doaj.art-e1f0a81617cc4ab6bd6df72c0ab6ee05 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T05:59:10Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e1f0a81617cc4ab6bd6df72c0ab6ee052022-12-22T04:41:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10640331064033Immunomodulatory role of metalloproteases in cancers: Current progress and future trendsQi Wang0Kai Wang1Xiaojing Tan2Zhenxiang Li3Haiyong Wang4Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaKey Laboratory of Epigenetics and Oncology, Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, ChinaDepartment of Oncology, Dongying People's Hospital, Dongying, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Medical Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaMetalloproteinases (MPs) is a large family of proteinases with metal ions in their active centers. According to the different domains metalloproteinases can be divided into a variety of subtypes mainly including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteases (ADAMs) and ADAMs with Thrombospondin Motifs (ADAMTS). They have various functions such as protein hydrolysis, cell adhesion and remodeling of extracellular matrix. Metalloproteinases expressed in multiple types of cancers and participate in many pathological processes involving tumor genesis and development, invasion and metastasis by regulating signal transduction and tumor microenvironment. In this review, based on the current research progress, we summarized the structure of MPs, their expression and especially immunomodulatory role and mechanisms in cancers. Additionally, a relevant and timely update of recent advances and future directions were provided for the diagnosis and immunotherapy targeting MPs in cancers.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1064033/fullmetalloproteasesimmunomodulatorycancersdiagnosistherapy |
| spellingShingle | Qi Wang Kai Wang Xiaojing Tan Zhenxiang Li Haiyong Wang Immunomodulatory role of metalloproteases in cancers: Current progress and future trends Frontiers in Immunology metalloproteases immunomodulatory cancers diagnosis therapy |
| title | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
| title_full | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
| title_fullStr | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
| title_full_unstemmed | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
| title_short | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
| title_sort | immunomodulatory role of metalloproteases in cancers current progress and future trends |
| topic | metalloproteases immunomodulatory cancers diagnosis therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1064033/full |
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